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PreDiabetes clinical trials
47 of 90 indexed PreDiabetes trials are currently recruiting.
90 US clinical trials · 47 currently recruiting
PreDiabetes is the subject of 90 registered US clinical trials on ClinicalTrials.gov, 47 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Ohio State University, running 5 of these trials.
The research picture
PreDiabetes has 90 registered US clinical trials, 47 of them open to new participants right now, about 52% of the total.
- 47
- recruiting participants now
- 52%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Ohio State University
Active & Recent Trials
90 total, page 1 of 2
Diabetes Clinical Decision Support
Milton S. Hershey Medical Center
NCT05447806
Triage Survey for Cardiovascular, Obesity, and Related Endocrine Trial Eligibility
Brooklyn Clinical Research
NCT06412536
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
Cleerly
NCT06112418
Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.
Clindove Research
NCT07106879
Blood Markers of Early Pancreas Cancer
University of Nebraska
NCT03568630
Strategies for Implementing a Postpartum Lifestyle Intervention in WIC Clinics
Tulane University
NCT06116149
Fresh Takes!: An Evaluation of the Impact of Receiving Fresh Food Boxes
Montefiore Medical Center
NCT06019624
Social Determinants and a Diabetes Prevention Program Tailored for African Americans
University of Missouri, Kansas City
NCT05301413
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
Ohio State University
NCT06055036
Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes
The University of Texas Health Science Center, Houston
NCT05119179
Effects of Walking in Greenspace and the Built Environment in Adults With Prediabetes: A Randomized Crossover Trial
University of Minnesota
NCT06365723
Food as Medicine for HIV and Diabetes
University of North Carolina, Chapel Hill
NCT05026723
Human Immunodeficiency Virus (HIV) Food Insecurities
Wake Forest University Health Sciences
NCT04943861
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
University of Michigan
NCT06007404
Cleaner Air for Lower Cardiometabolic Risk
NYU Langone Health
NCT05994937
Rural Alliance for Diabetes Prevention
University of Kansas Medical Center
NCT06252038
MEAL TIMING Study: Effect of Time-Restricted Feeding on 24-hour Glycemic Control, Blood Pressure, and Cardiovascular Disease Risk Factors in Adults With Prediabetes
University of Alabama at Birmingham
NCT03504683
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Stanford University
NCT05165706
Post Prandial Individual Responses to Different Foods
Stanford University
NCT06989164
The YMCA Healthy Lifestyle Program for Prediabetes
Young Men's Christian Association of the Blue Water Area
NCT06841796
Effect of Increased Physical Activity and Stopping Evening Snacking in Metabolic Health in Youth With Prediabetes
Baylor College of Medicine
NCT06782906
New T-UP: Engaging Vulnerable Students in Diabetes Prevention
University of California, Los Angeles
NCT07225218
Effect of Meal Composition and Timing Modification on Glucose Metabolism, Body Temperature and Sleep
Stanford University
NCT05413928
Peanuts for Cardiometabolic, Brain, and Intestinal Health
Georgia State University
NCT06867198
Night Owl Metabolism
Johns Hopkins University
NCT06507722
CGM Dynamic Index for Predicting Prediabetes in Cystic Fibrosis
Indiana University
NCT06642610
Mechanisms for Activation of Beige Adipose Tissue in Humans
Philip Kern
NCT04666636
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
Mayo Clinic
NCT06967558
Insulin and Insulin Pulses During Fasting
Mayo Clinic
NCT06424015
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes
Mayo Clinic
NCT06424106
How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-Diabetes
University of Nevada, Las Vegas
NCT06817252
Effects of Dihydroberberine (DHB) on GLP-1, Glycemic Control, Appetite, and Mood in Adults With Pre-Diabetes
Nanjing Nutrabuilding Bio-tech Co.
NCT07210684
Continuous Glucose Monitoring (CGM) in Prediabetes With Health Education Videos: Cohort 3
David S Black, PhD
NCT07477249
Ketogenic Diet and Diabetes Demonstration Project
University of New Mexi
NCT06115265
Nested Pilot Study Comparing Two Treatments to Reduce Type 2 Diabetes Risk in At-Risk Delawareans
University of Delaware
NCT07450118
Mobile Health Dietary Intervention for Stroke Survivors With Prediabetes or Type 2 Diabetes
University of Hawaii
NCT07120334
Dinner Time for Obesity and Prediabetes
Johns Hopkins University
NCT05745441
Glucose Variability and Cognition in Prediabetes
University of Maryland, Baltimore
NCT04201600
Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 Diabetes
Vanderbilt University
NCT06482944
Behavioral Approach for Latinas Addressing Nutrition, Cravings, and Eating Patterns to Prevent Type 2 Diabetes
University of California, San Diego
NCT07478263
WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time
Arizona State University
NCT06963736
Development of an Inclusive Adaptive Treatment Strategy for Weight Loss in People With Prediabetes Using a Sequential Multiple Assignment Randomized Trial
University of Alabama at Birmingham
NCT06976307
Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population
Massachusetts General Hospital
NCT05799222
Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center
Cedars-Sinai Medical Center
NCT06897982
Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food
Cambridge Health Alliance
NCT06988462
Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults
University of Arkansas
NCT06025292
CGM and Lifestyle Changes in Patients With Impaired Glucose Tolerance
Nemours Children's Clinic
NCT05387551
Behavioral Nudges for Diabetes Prevention (BEGIN) Trial in Primary Care
Northwestern University
NCT04869917
Evaluation of a Telehealth DPP With Medicare Patients at the University of Mississippi Medical Center
University of Mississippi Medical Center
NCT04822480
Randomized Trial of Exercise Promotion in Primary Care
Kaiser Permanente
NCT04445168
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the PreDiabetes Trial Landscape
90 indexed PreDiabetes studies · 47 recruiting (52%).
Phase mix: 3 late (III/IV) vs 5 early (I/II).
Top sponsor: Ohio State University (5 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for PreDiabetes?
PlainTrial tracks 90 US clinical trials for PreDiabetes, of which 47 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for PreDiabetes?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.