Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05119179 · ClinicalTrials.gov registry record · Phase 4
Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes
A Phase 4 study of PreDiabetes, sponsored by The University of Texas Health Science Center, Houston.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 300
- Enrollment target
- 1
- Study location
NCT05119179: Recruiting Phase 4 study of PreDiabetes, sponsored by The University of Texas Health Science Center, Houston.
NCT05119179 is a Phase 4 study of PreDiabetes that is actively recruiting participants, run by The University of Texas Health Science Center, Houston. The registered enrollment target is 300 participants, below the 700-participant average among 149 other PreDiabetes trials with a reported enrollment target (57% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05119179, a Phase 4 study of PreDiabetes, is actively recruiting participants, sponsored by The University of Texas Health Science Center, Houston.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
This project uses both transcriptomic- and genomic-level data to identify mechanisms of individual responses to glucagon-like peptide-1 (GLP-1) in Mexican-Americans with prediabetes. The GLP-1 hormone is essential for glucose reduction, weight loss, cardiovascular risk reduction, and renal protection. Newly discovered mechanisms will illuminate causal links between disease genotype and phenotype, which may ultimately guide personalized therapeutic approaches for type 2 diabetes, prediabetes, obesity, cardiovascular disease, renal disease, and other related diseases.
Primary Outcome
A rate which measures the ability of beta cells to secrete insulin
Conditions Studied
Interventions
- DRUG Semaglutide
Study Locations (1)
Texas
- UTHealth Clinical Research Unit (CRU) at UT Brownsville - Brownsville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2021-11-22 |
| Est. Completion | 2026-10-31 |
| Phase | Phase 4 |
What NCT05119179 shows while recruiting
NCT05119179 is an interventional study that assigns participants to a tested intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, below the 700-participant average among 149 other PreDiabetes trials with a reported enrollment target (57% lower).
The record links to 1 condition, with PreDiabetes appearing as the primary indexed condition, and to 1 intervention - of which Semaglutide is the first listed.
NCT05119179 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05119179 about?
NCT05119179 is a clinical study titled "Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes". This project uses both transcriptomic- and genomic-level data to identify mechanisms of individual responses to glucagon-like peptide-1 (GLP-1) in Mexican-Americans with prediabetes. The GLP-1 hormone is essential for glucose reduction, weight loss, cardiovascular risk reduction, and renal protectio...
What is the current status of trial NCT05119179?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 300 participants. The study started on 2021-11-22. Estimated completion is 2026-10-31.
What conditions does trial NCT05119179 study?
This clinical trial studies the following conditions: PreDiabetes.
What interventions are being tested in trial NCT05119179?
The interventions under investigation include: Semaglutide (DRUG).
Who is sponsoring clinical trial NCT05119179?
This trial is sponsored by The University of Texas Health Science Center, Houston, which has 732 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05119179 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for PreDiabetes
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05119179's enrollment target sits among peer trials
300 28th of 149 higher than 120 of 149 other PreDiabetes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other PreDiabetes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Treatment to Regress to Normoglycemia in Women with a Recent History of GDM
RECRUITING · Phase 4
-
The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics
RECRUITING · Phase 4
-
The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans
ACTIVE NOT RECRUITING · Phase 4
-
Use of Empagliflozin to Treat Prediabetes
ACTIVE NOT RECRUITING · Phase 4
-
Incretins in Impaired Fasting Glucose
COMPLETED · Phase 4
-
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
RECRUITING · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00353483 · 300 participants
Effect of Neoadjuvant or Adjuvant Systemic Therapy on Breast Cancers, Bone Marrow Cancer Cells, and Circulating Cancer Cells
- NCT00588185 · 300 participants · NA
[18F]-Fluoro-2-Deoxy-D-Glucose and -[18F] Dihydro-Testosterone Pet Imaging in Patients With Progressive Prostate Cancer
- NCT00682032 · 300 participants · NA
The Effect of Beta-glucan in Non-Small Cell Lung Cancer
- NCT00870064 · 300 participants · NA
The Treatment of Type I Open Fractures in Pediatrics
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI