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ClinicalTrials.gov 47 recruiting now official registry

PreDiabetes clinical trials

47 of 90 indexed PreDiabetes trials are currently recruiting.

90 US clinical trials · 47 currently recruiting

PreDiabetes is the subject of 90 registered US clinical trials on ClinicalTrials.gov, 47 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Ohio State University, running 5 of these trials.

The research picture

PreDiabetes has 90 registered US clinical trials, 47 of them open to new participants right now, about 52% of the total.

47
recruiting participants now
52%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
5
top sponsor: Ohio State University
Phase 11Phase 24Phase 43

Active & Recent Trials

90 total, page 2 of 2

ACTIVE NOT RECRUITING NA 352 participants

Promoting Successful Weight Loss in Primary Care in Louisiana Using Information Technology

Pennington Biomedical Research Center

NCT05523375

ACTIVE NOT RECRUITING NA 300 participants

Pharmacists' Delivery of Education to Prevent Diabetes in the New Orleans Hospitality Industry

Xavier University of Louisiana.

NCT07451314

ACTIVE NOT RECRUITING NA 174 participants

Technology-Supported Treatment of Sleep Apnea in Prediabetes

University of Chicago

NCT04225507

ACTIVE NOT RECRUITING NA 142 participants

The Inspiring Action to Prevent Diabetes Intervention

University of Michigan

NCT06001801

ACTIVE NOT RECRUITING NA 100 participants

Mastering Diabetes Study

Ohio University

NCT04454957

ACTIVE NOT RECRUITING Phase 2 96 participants

An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer

St. Jude Children's Research Hospital

NCT04742751

ACTIVE NOT RECRUITING Phase 4 90 participants

The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans

Ohio State University

NCT03938389

ACTIVE NOT RECRUITING NA 74 participants

Examining the Effects of Vivo on Physical Function and Glycemic Level in Sedentary Older With Prediabetes.

Impactiv

NCT06458530

ACTIVE NOT RECRUITING NA 65 participants

Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components

Ohio State University

NCT05318183

ACTIVE NOT RECRUITING Phase 4 60 participants

Use of Empagliflozin to Treat Prediabetes

Oregon State University

NCT05426525

ACTIVE NOT RECRUITING NA 60 participants

Recreational Basketball to Increase Participation in Diabetes Prevention

Kaiser Permanente

NCT05066542

ACTIVE NOT RECRUITING NA 57 participants

TREAT to Improve Cardiometabolic Health

Columbia University

NCT04465721

ACTIVE NOT RECRUITING NA 40 participants

Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes

Brigham and Women's Hospital

NCT05560971

ACTIVE NOT RECRUITING NA 20 participants

The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivors of Childhood Cancer

City of Hope Medical Center

NCT05023993

ACTIVE NOT RECRUITING NA 15 participants

Is the Degree of Perceived Effort During Resistance Exercise Important for Improvements in Blood Glucose

University of New Mexi

NCT06208189

COMPLETED NA 6,588 participants

Comparison of Outreach Methods to Encourage Enrollment in Diabetes Prevention and Weight Management Programs

Kaiser Permanente

NCT03200535

COMPLETED NA 2,423 participants

Vitamin D and Type 2 Diabetes Study

Tufts Medical Center

NCT01942694

COMPLETED 772 participants

Conventional and Metabolomic Predictors of Prediabetes & Insulin Resistance

University of Michigan

NCT05055219

COMPLETED NA 450 participants

Habit Building Software Application to Increase Engagement of Vulnerable Populations in the National Diabetes Prevention Program (NDPP) Lifestyle Change Program (LCP)

The Institute for Iterative Thinking

NCT06656273

COMPLETED NA 225 participants

Assessing the Effectiveness of a Weight Watchers-based Lifestyle Intervention for the Primary Prevention of Type 2 Diabetes

Indiana University

NCT02000024

COMPLETED NA 214 participants

Patient-centered Goal Setting in the National Diabetes Prevention Program

Denver Health and Hospital Authority

NCT05559515

COMPLETED NA 163 participants

Text Messaging for Weight Loss

Denver Health and Hospital Authority

NCT02063048

COMPLETED NA 104 participants

Trial of an Herb and Mineral Combination Product on Fasting Glucose in Adults at Risk for Developing Diabetes

NewChapter

NCT02146157

COMPLETED NA 80 participants

T-UP: Engaging Vulnerable Students in Diabetes Prevention

University of California, Los Angeles

NCT06385015

COMPLETED Phase 1 60 participants

Evaluation of Empagliflozin vs Standard Care in Veterans With Prediabetes

Charles George VA Medical Center

NCT06828731

COMPLETED NA 56 participants

Effect of Dietary Glycemic Index on Beta-cell Function

Seattle Institute for Biomedical and Clinical Research

NCT01386645

COMPLETED NA 53 participants

Diabetes Risk Education and Communication Trial

Northwestern University

NCT03283657

COMPLETED NA 48 participants

Impact of No-carrageenan Diet on Glucose Tolerance in Prediabetes

University of Illinois at Chicago

NCT02720393

COMPLETED NA 40 participants

Continuous Glucose Monitors (CGM) for Type 2 Diabetes (T2D) Risk Evaluation

Mary Ellen Vajravelu, MD

NCT05404711

COMPLETED NA 40 participants

CGM Plus GEM in Prediabetes

University of Colorado, Denver

NCT05580978

COMPLETED NA 34 participants

Family Diabetes Prevention Program Pilot Study

Johns Hopkins University

NCT05358444

COMPLETED NA 30 participants

Feasibility and Preliminary Effects of Fasting-Mimicking Diet in Asian Americans With Prediabetes

University of California, Irvine

NCT06518798

COMPLETED NA 30 participants

A Mindfulness-based Intervention for Adolescents With Prediabetes or Type 2 Diabetes

Indiana University

NCT07270900

COMPLETED NA 26 participants

Women's Lifestyle Balance Study

University of California, San Francisco

NCT03184337

COMPLETED NA 22 participants

Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Fat

Ohio State University

NCT02482610

COMPLETED NA 20 participants

Maternal Health Diabetes Prevention Study

Tulane University

NCT05343494

COMPLETED NA 20 participants

Cardioprotective Activities Of Whole Eggs On Vascular Endothelial Function In Prediabetic Adults

Ohio State University

NCT02364570

COMPLETED NA 15 participants

WorkWell: Work-based Activity and Metabolic Health

Arizona State University

NCT04269070

COMPLETED NA 10 participants

Morning Light Treatment to Improve Glucose Metabolism

Northwestern University

NCT03188263

COMPLETED NA 8 participants

Comparison of Time-Restricted Feeding Versus Grazing

Pennington Biomedical Research Center

NCT01895179

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Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 4
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the PreDiabetes Trial Landscape

90 indexed PreDiabetes studies · 47 recruiting (52%).

Phase mix: 3 late (III/IV) vs 5 early (I/II).

Top sponsor: Ohio State University (5 trials), 9 others listed. 40 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for PreDiabetes?

PlainTrial tracks 90 US clinical trials for PreDiabetes, of which 47 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for PreDiabetes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.