Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
PreDiabetes clinical trials
47 of 90 indexed PreDiabetes trials are currently recruiting.
90 US clinical trials · 47 currently recruiting
PreDiabetes is the subject of 90 registered US clinical trials on ClinicalTrials.gov, 47 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Ohio State University, running 5 of these trials.
The research picture
PreDiabetes has 90 registered US clinical trials, 47 of them open to new participants right now, about 52% of the total.
- 47
- recruiting participants now
- 52%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Ohio State University
Active & Recent Trials
90 total, page 2 of 2
Promoting Successful Weight Loss in Primary Care in Louisiana Using Information Technology
Pennington Biomedical Research Center
NCT05523375
Pharmacists' Delivery of Education to Prevent Diabetes in the New Orleans Hospitality Industry
Xavier University of Louisiana.
NCT07451314
Technology-Supported Treatment of Sleep Apnea in Prediabetes
University of Chicago
NCT04225507
The Inspiring Action to Prevent Diabetes Intervention
University of Michigan
NCT06001801
Mastering Diabetes Study
Ohio University
NCT04454957
An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer
St. Jude Children's Research Hospital
NCT04742751
The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans
Ohio State University
NCT03938389
Examining the Effects of Vivo on Physical Function and Glycemic Level in Sedentary Older With Prediabetes.
Impactiv
NCT06458530
Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components
Ohio State University
NCT05318183
Use of Empagliflozin to Treat Prediabetes
Oregon State University
NCT05426525
Recreational Basketball to Increase Participation in Diabetes Prevention
Kaiser Permanente
NCT05066542
TREAT to Improve Cardiometabolic Health
Columbia University
NCT04465721
Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes
Brigham and Women's Hospital
NCT05560971
The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivors of Childhood Cancer
City of Hope Medical Center
NCT05023993
Is the Degree of Perceived Effort During Resistance Exercise Important for Improvements in Blood Glucose
University of New Mexi
NCT06208189
Comparison of Outreach Methods to Encourage Enrollment in Diabetes Prevention and Weight Management Programs
Kaiser Permanente
NCT03200535
Vitamin D and Type 2 Diabetes Study
Tufts Medical Center
NCT01942694
Conventional and Metabolomic Predictors of Prediabetes & Insulin Resistance
University of Michigan
NCT05055219
Habit Building Software Application to Increase Engagement of Vulnerable Populations in the National Diabetes Prevention Program (NDPP) Lifestyle Change Program (LCP)
The Institute for Iterative Thinking
NCT06656273
Assessing the Effectiveness of a Weight Watchers-based Lifestyle Intervention for the Primary Prevention of Type 2 Diabetes
Indiana University
NCT02000024
Patient-centered Goal Setting in the National Diabetes Prevention Program
Denver Health and Hospital Authority
NCT05559515
Text Messaging for Weight Loss
Denver Health and Hospital Authority
NCT02063048
Trial of an Herb and Mineral Combination Product on Fasting Glucose in Adults at Risk for Developing Diabetes
NewChapter
NCT02146157
T-UP: Engaging Vulnerable Students in Diabetes Prevention
University of California, Los Angeles
NCT06385015
Evaluation of Empagliflozin vs Standard Care in Veterans With Prediabetes
Charles George VA Medical Center
NCT06828731
Effect of Dietary Glycemic Index on Beta-cell Function
Seattle Institute for Biomedical and Clinical Research
NCT01386645
Diabetes Risk Education and Communication Trial
Northwestern University
NCT03283657
Impact of No-carrageenan Diet on Glucose Tolerance in Prediabetes
University of Illinois at Chicago
NCT02720393
Continuous Glucose Monitors (CGM) for Type 2 Diabetes (T2D) Risk Evaluation
Mary Ellen Vajravelu, MD
NCT05404711
CGM Plus GEM in Prediabetes
University of Colorado, Denver
NCT05580978
Family Diabetes Prevention Program Pilot Study
Johns Hopkins University
NCT05358444
Feasibility and Preliminary Effects of Fasting-Mimicking Diet in Asian Americans With Prediabetes
University of California, Irvine
NCT06518798
A Mindfulness-based Intervention for Adolescents With Prediabetes or Type 2 Diabetes
Indiana University
NCT07270900
Women's Lifestyle Balance Study
University of California, San Francisco
NCT03184337
Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Fat
Ohio State University
NCT02482610
Maternal Health Diabetes Prevention Study
Tulane University
NCT05343494
Cardioprotective Activities Of Whole Eggs On Vascular Endothelial Function In Prediabetic Adults
Ohio State University
NCT02364570
WorkWell: Work-based Activity and Metabolic Health
Arizona State University
NCT04269070
Morning Light Treatment to Improve Glucose Metabolism
Northwestern University
NCT03188263
Comparison of Time-Restricted Feeding Versus Grazing
Pennington Biomedical Research Center
NCT01895179
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the PreDiabetes Trial Landscape
90 indexed PreDiabetes studies · 47 recruiting (52%).
Phase mix: 3 late (III/IV) vs 5 early (I/II).
Top sponsor: Ohio State University (5 trials), 9 others listed. 40 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for PreDiabetes?
PlainTrial tracks 90 US clinical trials for PreDiabetes, of which 47 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for PreDiabetes?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.