Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05008276 · ClinicalTrials.gov registry record
Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
A clinical trial of PreDiabetes and Type 2 Diabetes Mellitus, sponsored by Petter Bjornstad.
- Recruiting
- Registry status
- 100
- Enrollment target
- 2
- Study locations
NCT05008276: Recruiting study of PreDiabetes and Type 2 Diabetes Mellitus, sponsored by Petter Bjornstad.
NCT05008276 is a study of PreDiabetes and Type 2 Diabetes Mellitus that is actively recruiting participants, run by Petter Bjornstad. The registered enrollment target is 100 participants, below the 701-participant average among 149 other PreDiabetes trials with a reported enrollment target (86% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05008276, a study of PreDiabetes and Type 2 Diabetes Mellitus, is actively recruiting participants, sponsored by Petter Bjornstad.
- RECRUITING
- Registry status
- 100 participants
- Enrollment target
- 2
- Study locations
Study Summary
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the link between puberty and T2D-onset may explain the high burden of DKD in youth-onset T2D. A better understanding of the impact of puberty on kidney health is needed to promote preservation of native kidney function, especially in youth with T2D.
Primary Outcome
Measured by PAH Clearance
Conditions Studied
Interventions
- DRUG Aminohippurate Sodium Inj 20%
- DRUG Iohexol Inj 300 MG/ML
- DRUG Dextran 40
Study Locations (2)
Colorado
- Children's Hospital Colorado - Aurora
Washington
- Seattle Children's Hospital - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2021-09-27 |
| Est. Completion | 2027-12-01 |
What NCT05008276 shows while recruiting
NCT05008276 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 701-participant average among 149 other PreDiabetes trials with a reported enrollment target (86% lower).
The record links to 6 conditions, with PreDiabetes appearing as the primary indexed condition, and to 3 interventions - of which Aminohippurate Sodium Inj 20% is the first listed.
NCT05008276 reports a single indexed study location in Colorado, Washington.
Frequently Asked Questions
What is clinical trial NCT05008276 about?
NCT05008276 is a clinical study titled "Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)". Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accel...
What is the current status of trial NCT05008276?
This trial is currently recruiting. The enrollment target is 100 participants. The study started on 2021-09-27. Estimated completion is 2027-12-01.
What conditions does trial NCT05008276 study?
This clinical trial studies the following conditions: PreDiabetes, Type 2 Diabetes Mellitus, Diabetic Kidney Disease, Adolescent Obesity, Puberty.
What interventions are being tested in trial NCT05008276?
The interventions under investigation include: Aminohippurate Sodium Inj 20% (DRUG), Iohexol Inj 300 MG/ML (DRUG), Dextran 40 (DRUG).
Who is sponsoring clinical trial NCT05008276?
This trial is sponsored by Petter Bjornstad, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05008276 being conducted?
This trial has 2 study locations across Colorado, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for PreDiabetes
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05008276's enrollment target sits among peer trials
100 60th of 149 higher than 87 of 149 other PreDiabetes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other PreDiabetes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
RECRUITING · Phase 2
-
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
RECRUITING · NA
-
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
RECRUITING · NA
-
Diabetes Clinical Decision Support
RECRUITING · NA
-
Glucose Variability and Cognition in Prediabetes
RECRUITING
-
Food as Medicine for HIV and Diabetes
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01048281 · 100 participants
Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma
- NCT01161199 · 100 participants
The Use of Leukapheresis to Support HIV Pathogenesis Studies
- NCT01327690 · 100 participants · Early Phase 1
Mental Health in Veterans and Families After Group Therapies
- NCT01730781 · 100 participants
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI