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ClinicalTrials.gov 56 recruiting now official registry

Pancreatic Ductal Adenocarcinoma clinical trials

56 of 85 indexed Pancreatic Ductal Adenocarcinoma trials are currently recruiting.

85 US clinical trials · 56 currently recruiting

Pancreatic Ductal Adenocarcinoma is the subject of 85 registered US clinical trials on ClinicalTrials.gov, 56 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 68 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 5 of these trials.

The research picture

Pancreatic Ductal Adenocarcinoma has 85 registered US clinical trials, 56 of them open to new participants right now, about 66% of the total.

56
recruiting participants now
66%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
5
top sponsor: AstraZeneca
Phase 147Phase 221Phase 41

Active & Recent Trials

85 total, page 1 of 2

RECRUITING 20,000 participants

Pancreatic Cancer Early Detection Consortium

Arbor Research Collaborative for Health

NCT04970056

RECRUITING Early Phase 1 5,000 participants

Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals

Dana-Farber Cancer Institute

NCT06122896

RECRUITING 5,000 participants

A Prospective Registry for Patients at High-Risk for Pancreatic Cancer

Mayo Clinic

NCT06151223

RECRUITING 4,000 participants

UCSF PANC Cyst Registry

University of California, San Francisco

NCT04291651

RECRUITING 2,000 participants

Pancreatic Cancer Detection Consortium

City of Hope Medical Center

NCT06388967

RECRUITING Phase 1 1,130 participants

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

Revolution Medicines

NCT06445062

RECRUITING Phase 1 914 participants

A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT06131840

RECRUITING NA 845 participants

High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT02757859

RECRUITING Phase 1 630 participants

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

Eli Lilly and Company

NCT06586515

RECRUITING Phase 2 600 participants

Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer

Panbela Therapeutics

NCT05254171

RECRUITING Phase 1 534 participants

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

Revolution Medicines

NCT06128551

RECRUITING Phase 2 470 participants

A Study Comparing BMS-986504 in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)

Bristol-Myers Squibb

NCT07076121

RECRUITING Phase 2 455 participants

A Study of OT-101 With mFOLFIRINOX in Patients With Advanced and Unresectable or Metastatic Pancreatic Cancer

Oncotelic

NCT06079346

RECRUITING Phase 1 442 participants

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

Artios Pharma

NCT04657068

RECRUITING Phase 1 364 participants

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

Astellas Pharma

NCT07094204

RECRUITING Phase 2 320 participants

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

National Cancer Institute (NCI)

NCT06503146

RECRUITING Phase 1 295 participants

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

Verastem

NCT07020221

RECRUITING Phase 1 280 participants

Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors

AstraZeneca

NCT06005493

RECRUITING Phase 1 258 participants

Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or ICI, for the Treatment of Patients With Advanced Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)

Phanes Therapeutics

NCT05482893

RECRUITING Phase 2 224 participants

AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2

AstraZeneca

NCT06219941

RECRUITING Phase 1 220 participants

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

Merck Sharp & Dohme

NCT06428409

RECRUITING Phase 1 220 participants

A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours

Ipsen

NCT06305247

RECRUITING 200 participants

The Role of MicroRNA in the Diagnosis, Prognosis and Response to Treatment in Pancreatic Cancer

Nuvance Health

NCT04406831

RECRUITING 200 participants

Prediction of Neoadjuvant Chemotherapy Response in Pancreatic Cancer

City of Hope Medical Center

NCT07226154

RECRUITING Phase 1 162 participants

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

Novartis Pharmaceuticals

NCT06562192

RECRUITING Phase 1 147 participants

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Children's Oncology Group

NCT04851119

RECRUITING Phase 1 135 participants

A Study to Test Different Doses of BI 765049 in People With Advanced Cancer of the Colon, Rectum, Stomach, or Pancreas

Boehringer Ingelheim

NCT06882746

RECRUITING Phase 1 130 participants

Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

Janux Therapeutics

NCT05783622

RECRUITING Phase 1 117 participants

Study for AZD4360 in Participants With Advanced Solid Tumours

AstraZeneca

NCT06921928

RECRUITING Phase 1 112 participants

Lead-212 PSV359 Therapy for Patients With Solid Tumors

Perspective Therapeutics

NCT06710756

RECRUITING Phase 1 108 participants

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

AstraZeneca

NCT06218914

RECRUITING Phase 2 100 participants

Maintenance Combinatorial Myeloid Immunotherapy for Unresectable Pancreatic Cancer

University of Pennsylvania

NCT07199764

RECRUITING 100 participants

AI Derived Biomarker to Select Neoadjuvant Treatment for Borderline Resectable Pancreatic Ductal Adenocarcinoma

Roswell Park Cancer Institute

NCT06320717

RECRUITING Phase 1 96 participants

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

Dren Bio

NCT06999187

RECRUITING 80 participants

A Registry to Capture Patient Outcomes With KRAS G12R Altered Advanced Pancreatic Ductal Adenocarcinoma Treated With MEK Inhibitor-based Combination Therapy

Mandana Kamgar, MD

NCT05630989

RECRUITING Phase 1 78 participants

A Study to Determine the Effect of CT3001 in Patients with Advanced Solid Tumors

Crossignal Therapeutics

NCT06598007

RECRUITING Phase 1 71 participants

[18F]FPyQCP PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications

Blue Earth Diagnostics

NCT07432633

RECRUITING 70 participants

Hyperpolarized 13C MRI to Predict Response in Pancreatic Cancer

University of California, San Francisco

NCT06600906

RECRUITING Phase 1 70 participants

A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

AstraZeneca

NCT06147037

RECRUITING Phase 2 60 participants

A Study of NALIRIFOX in Combination With Radiation Therapy in People With Pancreatic Ductal Adenocarcinoma (PDAC)

Memorial Sloan Kettering Cancer Center

NCT05851924

RECRUITING Phase 2 60 participants

Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

Gulam Manji

NCT06048484

RECRUITING Phase 2 54 participants

Anti-CD38 Antibody With KRAS Vaccine and Anti-PD-1 Antibody in Subjects With Pancreatic Ductal Adenocarcinoma and Refractory Non-Small Cell Lung Cancer

Georgetown University

NCT06015724

RECRUITING Phase 2 50 participants

Utility of ctDNA in Early Switch of First-line mFOLFIRINOX in Metastatic Pancreatic Ductal Adenocarcinoma

University of Miami

NCT07096362

RECRUITING Phase 2 41 participants

Monthly Alternating NALIRIFOX and GnP in the First-Line Setting for Metastatic Pancreatic Ductal Adenocarcinoma

Northwell Health

NCT07163273

RECRUITING Phase 1 40 participants

Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 MAb, Administered Alone and in Combination with a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)

Phanes Therapeutics

NCT05431270

RECRUITING Phase 2 30 participants

Neoadjuvant Folfirinox Combined With Pembrolizumab Followed by Surgery for Patients With Resectable Pancreatic Cancer

Baylor College of Medicine

NCT05132504

RECRUITING Phase 1 28 participants

iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation

M.D. Anderson Cancer Center

NCT03608631

RECRUITING Phase 1 26 participants

PTM-101 in Pancreatic Ductal Adenocarcinoma (PDAC)

PanTher Therapeutics

NCT06673017

RECRUITING Phase 1 25 participants

A Study of ASP2138 Given Before Surgery, Then Chemotherapy After Surgery, in People With Pancreatic Ductal Cancer

Astellas Pharma Global Development

NCT07024615

RECRUITING Phase 1 24 participants

SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells

General Oncology

NCT04150042

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Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 21
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pancreatic Ductal Adenocarcinoma Trial Landscape

85 indexed Pancreatic Ductal Adenocarcinoma studies · 56 recruiting (66%).

Phase mix: 1 late (III/IV) vs 68 early (I/II).

Top sponsor: AstraZeneca (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pancreatic Ductal Adenocarcinoma?

PlainTrial tracks 85 US clinical trials for Pancreatic Ductal Adenocarcinoma, of which 56 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pancreatic Ductal Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.