Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Anxiety Disorders
Open-data reference.
85 US clinical trials · 42 currently recruiting
Active & Recent Trials
RIVER At Home Ketamine Protocols
RIVER Foundation
NCT06070766
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
National Institute of Mental Health (NIMH)
NCT00024635
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
National Institute of Mental Health (NIMH)
NCT00018057
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
Maastricht University Medical Center
NCT05656469
Enhancing Engagement by Integrating Goals and Concerns That Matter to Patients
Dartmouth-Hitchcock Medical Center
NCT06898593
Cultural Adaptation of a SSI for Youth Anxiety
University of Miami
NCT04729504
Resilience in Adolescent Development
University of Texas Southwestern Medical Center
NCT03458936
Technology Exposure and Child Health: Wellness Impact and Social Effects: an Observational Product Registry Study
Aura
NCT06664944
CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos
Drexel University
NCT06139159
Ketamine Treatment Plans for Chronic Conditions
RIVER Foundation
NCT06038409
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders
National Institute of Mental Health (NIMH)
NCT00397111
Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety
Baylor College of Medicine
NCT05843695
Neurostimulation Versus Therapy for Problems With Emotions
Duke University
NCT05712057
Whole Health in VA Mental Health: Omnis Salutis
VA Office of Research and Development
NCT05400252
An Exploratory Study Examining Biopsychosocial Markers of Anxiety and Depression
Singula Institute
NCT05466851
A Comparison of Two School Based Interventions to Manage Anxiety in Autistic Students
University of Colorado, Denver
NCT05863520
A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences
Massachusetts General Hospital
NCT06929442
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
University of Texas at Austin
NCT05427708
Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
Laureate Institute for Brain Research
NCT06004115
Trial With the Treatment of Sertraline in Youth With Generalized, Separation and/or Social Anxiety Disorders.
University of Cincinnati
NCT04221997
Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety
National Institute of Mental Health (NIMH)
NCT06595953
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
University of Pittsburgh
NCT05658796
Internet-delivered Cognitive-Behavioral Therapy for Adolescents With Autism and Anxiety
Baylor College of Medicine
NCT06537128
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
University of California, San Diego
NCT06273527
Expansion and Evaluation of AI-generated Clinical Assessment (AI-COA®) of Depression and Anxiety Severity
Deliberate Solutions
NCT06923995
Pramipexole to Enhance Social Connections
University of California, San Diego
NCT06269146
Reducing Mental Health Disparities Among Latinxs With a Telenovela Intervention
University of Nevada, Reno
NCT06163599
Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons
University of Wisconsin, Madison
NCT06162624
Initial Assessment of the Feasibility and Efficacy of a Scalable Digital CBT for Generalized Anxiety and Associated Health Behaviors in a Cardiovascular Disease Population
Boston University Charles River Campus
NCT04895995
Measurement-Based Care (MBC) Implementation, Effectiveness, and Mechanisms of Change
Carilion Clinic
NCT06671158
Online Parent Education for Child Anxiety
Massachusetts General Hospital
NCT07153250
Cannabidiol-Assisted Learning for Managing Generalized Anxiety Disorder
Wayne State University
NCT07123467
Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method
Georgetown University
NCT07028216
Modulating Anxious Coping
Medical University of South Carolina
NCT04824105
Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II
Brigham and Women's Hospital
NCT05555875
DINO RCT - Treating Anxiety in Children With Autism
Hugo W. Moser Research Institute at Kennedy Krieger
NCT06066983
Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
Massachusetts General Hospital
NCT05962879
Managing Anxiety in Pediatric Primary Care (MAPP)
UConn Health
NCT06104904
A Single Session Parenting Intervention for Children on a Outpatient Therapy Waitlist
Massachusetts General Hospital
NCT06043271
Mindful Self-Compassion for Anxiety Disorders and Depression
Georgetown University
NCT05671419
Modulating Escape Using Focused Ultrasound
Medical University of South Carolina
NCT06273904
Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth
SoundHeal
NCT07364799
Fluoxetine vs CBT in Childhood Anxiety Disorders
Children's Hospital Los Angeles
NCT04760275
Reconnecting to Ourselves and Others in Virtual Meetings (ROOM)
Massachusetts General Hospital
NCT06360562
SKY Breath Intervention
University of California, San Francis
NCT05388110
TCI-Massage Clinical Trial
The Center for Victims of Torture, United States
NCT07482358
Transitioning Emotionally and Academically to Middle School Successfully (TEAMSS)
UConn Health
NCT05145387
Pre-Post Intervention Study to Investigate the Safety, Feasibility, & Efficacy of the NeurGear ZenBud System for the Treatment of Anxiety & Anxiety-Related Symptoms
NeurGear
NCT06574971
Focused Ultrasound Amygdala Neuromodulation
University of Texas at Austin
NCT05228964
PRISM for Depression and Anxiety in Young Adults With Cancer
Dana-Farber Cancer Institute
NCT06502483
Testing a Transdiagnostic TMS Treatment Target
Brigham and Women's Hospital
NCT06282146
Harnessing Mobile Technology to Reduce Mental Health Disorders in College Populations
Washington University School of Medicine
NCT04162847
Transdiagnostic Behavioral Activation Therapy for Youth Anxiety and Depression
Rutgers University
NCT01829100
AZD7325 Proof of Concept in Patients With Generalized Anxiety Disorder (GAD)
AstraZeneca
NCT00808249
Safety and Efficacy Maintenance Study of Quetiapine SR to Treat GAD Patients.
AstraZeneca
NCT00314210
A Comparison of Duloxetine Hydrochloride, Marketed Comparator, and Placebo in the Treatment of Generalized Anxiety Disorder
Eli Lilly and Company
NCT00122850
Telephone-Based Care Management Program for Individuals With Anxiety Disorders
University of Pittsburgh
NCT00158327
Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety Disorders
Boston University Charles River Campus
NCT01243606
A Cognitive-Behavioral Intervention for Depression and Anxiety in COPD
US Department of Veterans Affairs
NCT00105911
School-based Treatment of Anxiety Research Study (STARS)
UConn Health
NCT01761396
Treatment for Specific Phobias in Children
Virginia Polytechnic Institute and State University
NCT00051220
Flourishing and Virtue in Cognitive-Behavioral Therapy for Anxiety and Depressive Disorders
Boston University Charles River Campus
NCT05120232
Explanatory Clinical Trial of a Novel Parent Intervention for Childhood Anxiety (SPACE)
Yale University
NCT02310152
Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD)
University Hospitals Cleveland Medical Center
NCT00671853
Retraining Attention to Treat Alcohol Dependence and Social Anxiety
University of Cincinnati
NCT01886716
Family-Focused CBT Skills App and Standard Self Help Options for Childhood Anxiety
Kansas City Center for Anxiety Treatment, P.A.
NCT03269370
Inhaled Oxytocin and HPA Axis Reactivity
University of North Carolina, Chapel Hill
NCT03593473
Mindfulness-based Stress Reduction and Cognitive Function in Stress and Aging
Washington University School of Medicine
NCT01693874
Personalized Feedback for Smokers With Elevated Anxiety Sensitivity
University of Houston
NCT03382093
Feasibility of Collateral Information Review and Its Impact on Clinical Decision-Making
Mclean Hospital
NCT04635748
Reward Processes and Rehearsal in Exposure Therapy
University of California, Los Angeles
NCT06132425
Integrated CBT for Cannabis Dependence With Co-occurring Anxiety Disorders
Louisiana State University and A&M College
NCT01875796
Transdiagnostic Sleep and Anxiety Treatment
Florida State University
NCT03664310
A Single-Session Intervention for Families on Waitlists for Child Anxiety Treatment
Florida International University
NCT05841680
Anxiety in Older Veterans
VA Office of Research and Development
NCT02400723
Threat Interpretation Bias as Cognitive Marker and Treatment Target in Pediatric Anxiety
University of Denver
NCT04245501
Effect of Mindfulness Meditation on Physiological Response to Unpredictable Stimuli
Georgetown University
NCT03206437
Evaluating a Personalized Trans-Diagnostic Group Therapy for Anxiety
Stanford University
NCT03457922
Benzodiazepine Taper With Cognitive Behavioral Therapy in Patients Using Prescription Opioids
University of California, Los Angeles
NCT05573906
Relaxation Treatment for Anxiety in Adults Aged 60 or Older
Palo Alto Veterans Institute for Research
NCT02429778
School-based Treatment for Anxious Children
Johns Hopkins University
NCT00536094
Study of Treatment for Opioid Dependence and Anxiety Disorders
Mclean Hospital
NCT02252068
Treatment Effects of Escitalopram (Lexapro®) on Generalized Anxiety Disorder in Patients With HIV and AIDS
Duke University
NCT00887679
Strategies for Treating Anxiety Research Study
University of Nevada, Las Vegas
NCT05398016
Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders
Washington University School of Medicine
NCT01333098
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 5 |
| Phase 2 | 6 |
| Phase 3 | 8 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Anxiety Disorders Trial Landscape
ClinicalTrials.gov lists 85 US studies indexed under Anxiety Disorders, and 42 of those are currently open to recruitment — roughly 49% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Anxiety Disorders shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 11 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Anxiety Disorders is led by Massachusetts General Hospital with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 85 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Anxiety Disorders?
PlainTrial tracks 85 US clinical trials for Anxiety Disorders, of which 42 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Anxiety Disorders?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.