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ClinicalTrials.gov 56 recruiting now official registry

Pancreatic Ductal Adenocarcinoma clinical trials

56 of 85 indexed Pancreatic Ductal Adenocarcinoma trials are currently recruiting.

85 US clinical trials · 56 currently recruiting

Pancreatic Ductal Adenocarcinoma is the subject of 85 registered US clinical trials on ClinicalTrials.gov, 56 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 68 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 5 of these trials.

The research picture

Pancreatic Ductal Adenocarcinoma has 85 registered US clinical trials, 56 of them open to new participants right now, about 66% of the total.

56
recruiting participants now
66%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
5
top sponsor: AstraZeneca
Phase 147Phase 221Phase 41

Active & Recent Trials

85 total, page 2 of 2

RECRUITING Phase 2 24 participants

Endoscopic Ultrasound Radiofrequency Ablation and Immunotherapy Pembrolizumab for Locally Advanced Unresectable and Metastatic Pancreatic Duct Adenocarcinoma

The University of Texas Health Science Center, Houston

NCT06831136

RECRUITING Phase 1 20 participants

A Study to Evaluate the Safety and Tolerability of SX-682 in Combination With Nivolumab as a Maintenance Therapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

University of Rochester

NCT04477343

RECRUITING Early Phase 1 20 participants

PHL Treatment in Pancreatic Cancer

Fox Chase Cancer Center

NCT05365893

RECRUITING NA 16 participants

Investigating Targetable Metabolic Pathways Sustaining Pancreatic Cancer

Rutgers, The State University of New Jersey

NCT05296421

RECRUITING Early Phase 1 10 participants

Fecal Microbial Transplants for the Treatment of Pancreatic Cancer

M.D. Anderson Cancer Center

NCT04975217

RECRUITING Phase 1 9 participants

Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other Solid Tumors

Radiopharm Theranostics

NCT05799274

ACTIVE NOT RECRUITING Phase 1 750 participants

A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors

Eli Lilly and Company

NCT06607185

ACTIVE NOT RECRUITING 600 participants

A Registry for BRCA Mutation Carriers With Pancreatic Ductal Adenocarcinoma

Memorial Sloan Kettering Cancer Center

NCT01983410

ACTIVE NOT RECRUITING 317 participants

The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

H. Lee Moffitt Cancer Center and Research Institute

NCT05692596

ACTIVE NOT RECRUITING Phase 1 302 participants

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

AbbVie

NCT06084481

ACTIVE NOT RECRUITING Phase 1 222 participants

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

Revolution Medicines

NCT05462717

ACTIVE NOT RECRUITING Phase 1 179 participants

Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

NGM Biopharmaceuticals

NCT04913337

ACTIVE NOT RECRUITING Phase 1 158 participants

A Study of ELI-002 7P in Subjects With KRAS/NRAS Mutated Solid Tumors

Elicio Therapeutics

NCT05726864

ACTIVE NOT RECRUITING Phase 2 122 participants

A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors

National Cancer Institute (NCI)

NCT02498613

ACTIVE NOT RECRUITING Phase 1 102 participants

A Study to Evaluate Safety, Pharmacokinetics, & Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-care Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors; Urothelial Carcinoma Substudy in Association With RO7496353 Study GO44010

Genentech

NCT05867121

ACTIVE NOT RECRUITING Phase 1 100 participants

Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor

Affini-T Therapeutics

NCT06105021

ACTIVE NOT RECRUITING Phase 1 65 participants

A Study of PF-08046052/SGN-EGFRd2 in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05983133

ACTIVE NOT RECRUITING Phase 1 58 participants

A Study to Test KISIMA-02 Vaccine-based Immunotherapy and Ezabenlimab in People With Pancreatic Cancer

Boehringer Ingelheim

NCT05846516

ACTIVE NOT RECRUITING Phase 1 55 participants

GDC-0449 and Erlotinib Hydrochloride With or Without Gemcitabine Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer or Solid Tumors That Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT00878163

ACTIVE NOT RECRUITING Phase 2 48 participants

A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma

Thomas Jefferson University

NCT04111172

ACTIVE NOT RECRUITING Phase 2 42 participants

Nab-Paclitaxel + Cisplatin + Gemcitabine in Untreated Metastatic Pancreatic Adenocarcinoma

HonorHealth Research Institute

NCT03915444

ACTIVE NOT RECRUITING Early Phase 1 30 participants

Imaging Study of 18F-FAC PET Scans to Assess Standard Treatment in People With Pancreatic Cancer

Memorial Sloan Kettering Cancer Center

NCT05141643

ACTIVE NOT RECRUITING Phase 2 29 participants

A Study of Glipizide to Treat High Blood Sugar in People With Pancreatic Cancer

Memorial Sloan Kettering Cancer Center

NCT06168812

ACTIVE NOT RECRUITING Phase 2 28 participants

Enfortumab Vedotin in Previously Treated Locally Advanced or Metastatic Pancreatic Cancer (EPIC)

University of Kansas Medical Center

NCT05915351

ACTIVE NOT RECRUITING Early Phase 1 28 participants

A Feasibility Study of Ketorolac Treatment for Cachexia in Patients With Advanced Pancreatic Ductal Adenocarcinoma

Andrew Hendifar, MD

NCT05336266

ACTIVE NOT RECRUITING Phase 2 24 participants

AGEN1423 and Botensilimab w/ or w/o Chemo in PDAC

Bruno Bockorny

NCT05632328

ACTIVE NOT RECRUITING NA 24 participants

Physical Activity and Nutrition to Halt Elevated Risk in the Pancreas Interception Center

H. Lee Moffitt Cancer Center and Research Institute

NCT06712797

ACTIVE NOT RECRUITING Phase 4 20 participants

Hepatic Artery Chemotherapy for Patients With Localized Pancreas Cancer

Duke University

NCT05634720

ACTIVE NOT RECRUITING Phase 1 18 participants

Vaccine Therapy and Sargramostim in Treating Patients With Pancreas Cancer That Cannot Be Removed By Surgery

National Cancer Institute (NCI)

NCT00669734

ACTIVE NOT RECRUITING Phase 1 16 participants

Ivosidenib + mFOLFIRINOX in Patients With Resectable Pancreatic Adenocarcinoma

Case Comprehensive Cancer Center

NCT05209074

ACTIVE NOT RECRUITING Phase 2 12 participants

ZN-c3 + Gemcitabine in Pancreatic Cancer

Brandon Huffman, MD

NCT06015659

ACTIVE NOT RECRUITING Phase 2 10 participants

The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer

Alliance for Clinical Trials in Oncology

NCT06115499

COMPLETED 300 participants

Utilizing a Multi-gene Testing Approach to Identify Hereditary Pancreatic Cancer

Ambry Genetics

NCT02790944

COMPLETED Phase 1 54 participants

INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors

Incyte Corporation

NCT04580485

COMPLETED 30 participants

CT Pancreas Perfusion

Mayo Clinic

NCT00588367

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Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 21
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pancreatic Ductal Adenocarcinoma Trial Landscape

85 indexed Pancreatic Ductal Adenocarcinoma studies · 56 recruiting (66%).

Phase mix: 1 late (III/IV) vs 68 early (I/II).

Top sponsor: AstraZeneca (5 trials), 9 others listed. 35 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pancreatic Ductal Adenocarcinoma?

PlainTrial tracks 85 US clinical trials for Pancreatic Ductal Adenocarcinoma, of which 56 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pancreatic Ductal Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.