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AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2
NCT06219941 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to assess the safety, tolerability, efficacy, pharmacokinetics (PK), and immunogenicity of AZD0901 as monotherapy and in combination with anti-cancer agents in participants with locally advanced unresectable or metastatic solid tumours expressing CLDN18.2.
Conditions Studied
Interventions
- DRUG Leucovorin
- DRUG Irinotecan
- DRUG 5-Fluorouracil
- DRUG AZD0901
- DRUG l-leucovorin
Study Locations (20)
Other
- Research Site — Melbourne
- Research Site — Murdoch
- Research Site — Randwick
- Research Site — Changsha
- Research Site — Chengdu
- Research Site — Tbilisi
- Research Site — Chūōku
- Research Site — Kashiwa
- Research Site — Kitaadachi-gun
California
- Research Site — Orange
- Research Site — Palo Alto
- Research Site — Santa Rosa
Ontario
- Research Site — Kingston
- Research Site — Toronto
Quebec
- Research Site — Montreal
- Research Site — Sherbrooke
Kentucky
- Research Site — Louisville
New York
- Research Site — Commack
Rhode Island
- Research Site — Providence
Texas
- Research Site — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 224 participants |
| Start Date | 2023-12-13 |
| Est. Completion | 2027-09-30 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06219941
The ClinicalTrials.gov registry entry for NCT06219941 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 224 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Gastric Cancer appearing as the primary indexed condition, and to 5 interventions — of which Leucovorin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06219941 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, California, Ontario. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06219941 about?
NCT06219941 is a clinical study titled "AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2". The purpose of this study is to assess the safety, tolerability, efficacy, pharmacokinetics (PK), and immunogenicity of AZD0901 as monotherapy and in combination with anti-cancer agents in participants with locally advanced unresectable or metastatic solid tumours expressing CLDN18.2.
What is the current status of trial NCT06219941?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 224 participants. The study started on 2023-12-13. Estimated completion is 2027-09-30.
What conditions does trial NCT06219941 study?
This clinical trial studies the following conditions: Gastric Cancer, Pancreatic Ductal Adenocarcinoma, Biliary Tract Cancer, Gastroesophageal Junction Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06219941?
The interventions under investigation include: Leucovorin (DRUG), Irinotecan (DRUG), 5-Fluorouracil (DRUG), AZD0901 (DRUG), l-leucovorin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06219941?
This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06219941 being conducted?
This trial has 20 study locations across California, Kentucky, New York, Rhode Island, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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