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RECRUITING Phase 2

Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

NCT06048484 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to combine standard radiation therapy with drugs that encourages the body's immune system against cancer cells and simultaneously adding drugs which also target the pathway that the tumor uses to evade the immune system (CD73 and A2a/b). The study hopes that these drugs will work in concert with radiation therapy to kill cancer cells. The specific goal of this study is to ensure that treatment with zimberelimab and stereotactic body radiation therapy (SBRT) alone or in combination with quemliclustat (a drug which blocks CD73), with or without etrumadenant (a drug which blocks the A2a/b) given before surgery is safe and if it can further increase the immune response against the tumor.

Interventions

  • DRUG Zimberelimab
  • DRUG Quemliclustat
  • DRUG Modified FOLFIRINOX
  • DRUG Etrumadenant
  • RADIATION Stereotactic body radiotherapy (SBRT)

Study Locations (5)

New York

  • Northwell Health R.J. Zuckerberg Cancer Center — Lake Success
  • Columbia University Irving Medical Center — New York

North Carolina

  • UNC Hospitals, The University of North Carolina at Chapel Hill — Chapel Hill

Pennsylvania

  • University of Pennsylvania, Abramson Cancer Center — Philadelphia

Wisconsin

  • Medical College of Wisconsin — Milwaukee

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2024-05-10
Est. Completion 2027-04
Phase Phase 2

Sponsor

Gulam Manji

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06048484

The ClinicalTrials.gov registry entry for NCT06048484 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gulam Manji, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Pancreatic Ductal Adenocarcinoma appearing as the primary indexed condition, and to 5 interventions — of which Zimberelimab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06048484 reports 5 study locations spanning 4 distinct geographic areas — top geographies include New York, North Carolina, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06048484 about?

NCT06048484 is a clinical study titled "Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma". The purpose of this study is to combine standard radiation therapy with drugs that encourages the body's immune system against cancer cells and simultaneously adding drugs which also target the pathway that the tumor uses to evade the immune system (CD73 and A2a/b). The study hopes that these drugs ...

What is the current status of trial NCT06048484?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2024-05-10. Estimated completion is 2027-04.

What conditions does trial NCT06048484 study?

This clinical trial studies the following conditions: Pancreatic Ductal Adenocarcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06048484?

The interventions under investigation include: Zimberelimab (DRUG), Quemliclustat (DRUG), Modified FOLFIRINOX (DRUG), Etrumadenant (DRUG), Stereotactic body radiotherapy (SBRT) (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06048484?

This trial is sponsored by Gulam Manji, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06048484 being conducted?

This trial has 5 study locations across New York, North Carolina, Pennsylvania, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial