Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Pancreatic Ductal Adenocarcinoma

Open-data reference.

85 US clinical trials · 56 currently recruiting

Active & Recent Trials

RECRUITING 20,000 participants

Pancreatic Cancer Early Detection Consortium

Arbor Research Collaborative for Health

NCT04970056

RECRUITING Early Phase 1 5,000 participants

Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals

Dana-Farber Cancer Institute

NCT06122896

RECRUITING 5,000 participants

A Prospective Registry for Patients at High-Risk for Pancreatic Cancer

Mayo Clinic

NCT06151223

RECRUITING 4,000 participants

UCSF PANC Cyst Registry

University of California, San Francis

NCT04291651

RECRUITING 2,000 participants

Pancreatic Cancer Detection Consortium

City of Hope Medical Center

NCT06388967

RECRUITING Phase 1 1,130 participants

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

Revolution Medicines

NCT06445062

RECRUITING Phase 1 914 participants

A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT06131840

RECRUITING NA 845 participants

High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT02757859

RECRUITING Phase 1 630 participants

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

Eli Lilly and Company

NCT06586515

RECRUITING Phase 2 600 participants

Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer

Panbela Therapeutics

NCT05254171

RECRUITING Phase 1 534 participants

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

Revolution Medicines

NCT06128551

RECRUITING Phase 2 470 participants

A Study Comparing BMS-986504 in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)

Bristol-Myers Squibb

NCT07076121

RECRUITING Phase 2 455 participants

A Study of OT-101 With mFOLFIRINOX in Patients With Advanced and Unresectable or Metastatic Pancreatic Cancer

Oncotelic

NCT06079346

RECRUITING Phase 1 442 participants

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

Artios Pharma

NCT04657068

RECRUITING Phase 1 364 participants

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

Astellas Pharma

NCT07094204

RECRUITING Phase 2 320 participants

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

National Cancer Institute (NCI)

NCT06503146

RECRUITING Phase 1 295 participants

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

Verastem

NCT07020221

RECRUITING Phase 1 280 participants

Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors

AstraZeneca

NCT06005493

RECRUITING Phase 1 258 participants

Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or ICI, for the Treatment of Patients With Advanced Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)

Phanes Therapeutics

NCT05482893

RECRUITING Phase 2 224 participants

AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2

AstraZeneca

NCT06219941

RECRUITING Phase 1 220 participants

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

Merck Sharp & Dohme

NCT06428409

RECRUITING Phase 1 220 participants

A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours

Ipsen

NCT06305247

RECRUITING 200 participants

The Role of MicroRNA in the Diagnosis, Prognosis and Response to Treatment in Pancreatic Cancer

Nuvance Health

NCT04406831

RECRUITING 200 participants

Prediction of Neoadjuvant Chemotherapy Response in Pancreatic Cancer

City of Hope Medical Center

NCT07226154

RECRUITING Phase 1 162 participants

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

Novartis Pharmaceuticals

NCT06562192

RECRUITING Phase 1 147 participants

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Children's Oncology Group

NCT04851119

RECRUITING Phase 1 135 participants

A Study to Test Different Doses of BI 765049 in People With Advanced Cancer of the Colon, Rectum, Stomach, or Pancreas

Boehringer Ingelheim

NCT06882746

RECRUITING Phase 1 130 participants

Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

Janux Therapeutics

NCT05783622

RECRUITING Phase 1 117 participants

Study for AZD4360 in Participants With Advanced Solid Tumours

AstraZeneca

NCT06921928

RECRUITING Phase 1 112 participants

Lead-212 PSV359 Therapy for Patients With Solid Tumors

Perspective Therapeutics

NCT06710756

RECRUITING Phase 1 108 participants

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

AstraZeneca

NCT06218914

RECRUITING Phase 2 100 participants

Maintenance Combinatorial Myeloid Immunotherapy for Unresectable Pancreatic Cancer

University of Pennsylvania

NCT07199764

RECRUITING 100 participants

AI Derived Biomarker to Select Neoadjuvant Treatment for Borderline Resectable Pancreatic Ductal Adenocarcinoma

Roswell Park Cancer Institute

NCT06320717

RECRUITING Phase 1 96 participants

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

Dren Bio

NCT06999187

RECRUITING 80 participants

A Registry to Capture Patient Outcomes With KRAS G12R Altered Advanced Pancreatic Ductal Adenocarcinoma Treated With MEK Inhibitor-based Combination Therapy

Mandana Kamgar, MD

NCT05630989

RECRUITING Phase 1 78 participants

A Study to Determine the Effect of CT3001 in Patients with Advanced Solid Tumors

Crossignal Therapeutics

NCT06598007

RECRUITING Phase 1 71 participants

[18F]FPyQCP PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications

Blue Earth Diagnostics

NCT07432633

RECRUITING 70 participants

Hyperpolarized 13C MRI to Predict Response in Pancreatic Cancer

University of California, San Francis

NCT06600906

RECRUITING Phase 1 70 participants

A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

AstraZeneca

NCT06147037

RECRUITING Phase 2 60 participants

A Study of NALIRIFOX in Combination With Radiation Therapy in People With Pancreatic Ductal Adenocarcinoma (PDAC)

Memorial Sloan Kettering Cancer Center

NCT05851924

RECRUITING Phase 2 60 participants

Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

Gulam Manji

NCT06048484

RECRUITING Phase 2 54 participants

Anti-CD38 Antibody With KRAS Vaccine and Anti-PD-1 Antibody in Subjects With Pancreatic Ductal Adenocarcinoma and Refractory Non-Small Cell Lung Cancer

Georgetown University

NCT06015724

RECRUITING Phase 2 50 participants

Utility of ctDNA in Early Switch of First-line mFOLFIRINOX in Metastatic Pancreatic Ductal Adenocarcinoma

University of Miami

NCT07096362

RECRUITING Phase 2 41 participants

Monthly Alternating NALIRIFOX and GnP in the First-Line Setting for Metastatic Pancreatic Ductal Adenocarcinoma

Northwell Health

NCT07163273

RECRUITING Phase 1 40 participants

Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 MAb, Administered Alone and in Combination with a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)

Phanes Therapeutics

NCT05431270

RECRUITING Phase 2 30 participants

Neoadjuvant Folfirinox Combined With Pembrolizumab Followed by Surgery for Patients With Resectable Pancreatic Cancer

Baylor College of Medicine

NCT05132504

RECRUITING Phase 1 28 participants

iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation

M.D. Anderson Cancer Center

NCT03608631

RECRUITING Phase 1 26 participants

PTM-101 in Pancreatic Ductal Adenocarcinoma (PDAC)

PanTher Therapeutics

NCT06673017

RECRUITING Phase 1 25 participants

A Study of ASP2138 Given Before Surgery, Then Chemotherapy After Surgery, in People With Pancreatic Ductal Cancer

Astellas Pharma Global Development

NCT07024615

RECRUITING Phase 1 24 participants

SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells

General Oncology

NCT04150042

RECRUITING Phase 2 24 participants

Endoscopic Ultrasound Radiofrequency Ablation and Immunotherapy Pembrolizumab for Locally Advanced Unresectable and Metastatic Pancreatic Duct Adenocarcinoma

The University of Texas Health Science Center, Houston

NCT06831136

RECRUITING Phase 1 20 participants

A Study to Evaluate the Safety and Tolerability of SX-682 in Combination With Nivolumab as a Maintenance Therapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

University of Rochester

NCT04477343

RECRUITING Early Phase 1 20 participants

PHL Treatment in Pancreatic Cancer

Fox Chase Cancer Center

NCT05365893

RECRUITING NA 16 participants

Investigating Targetable Metabolic Pathways Sustaining Pancreatic Cancer

Rutgers, The State University of New Jersey

NCT05296421

RECRUITING Early Phase 1 10 participants

Fecal Microbial Transplants for the Treatment of Pancreatic Cancer

M.D. Anderson Cancer Center

NCT04975217

RECRUITING Phase 1 9 participants

Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other Solid Tumors

Radiopharm Theranostics

NCT05799274

ACTIVE NOT RECRUITING Phase 1 750 participants

A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors

Eli Lilly and Company

NCT06607185

ACTIVE NOT RECRUITING 600 participants

A Registry for BRCA Mutation Carriers With Pancreatic Ductal Adenocarcinoma

Memorial Sloan Kettering Cancer Center

NCT01983410

ACTIVE NOT RECRUITING 317 participants

The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

H. Lee Moffitt Cancer Center and Research Institute

NCT05692596

ACTIVE NOT RECRUITING Phase 1 302 participants

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

AbbVie

NCT06084481

ACTIVE NOT RECRUITING Phase 1 222 participants

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

Revolution Medicines

NCT05462717

ACTIVE NOT RECRUITING Phase 1 179 participants

Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

NGM Biopharmaceuticals

NCT04913337

ACTIVE NOT RECRUITING Phase 1 158 participants

A Study of ELI-002 7P in Subjects With KRAS/NRAS Mutated Solid Tumors

Elicio Therapeutics

NCT05726864

ACTIVE NOT RECRUITING Phase 2 122 participants

A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors

National Cancer Institute (NCI)

NCT02498613

ACTIVE NOT RECRUITING Phase 1 102 participants

A Study to Evaluate Safety, Pharmacokinetics, & Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-care Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors; Urothelial Carcinoma Substudy in Association With RO7496353 Study GO44010

Genentech

NCT05867121

ACTIVE NOT RECRUITING Phase 1 100 participants

Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor

Affini-T Therapeutics

NCT06105021

ACTIVE NOT RECRUITING Phase 1 65 participants

A Study of PF-08046052/SGN-EGFRd2 in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05983133

ACTIVE NOT RECRUITING Phase 1 58 participants

A Study to Test KISIMA-02 Vaccine-based Immunotherapy and Ezabenlimab in People With Pancreatic Cancer

Boehringer Ingelheim

NCT05846516

ACTIVE NOT RECRUITING Phase 1 55 participants

GDC-0449 and Erlotinib Hydrochloride With or Without Gemcitabine Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer or Solid Tumors That Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT00878163

ACTIVE NOT RECRUITING Phase 2 48 participants

A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma

Thomas Jefferson University

NCT04111172

ACTIVE NOT RECRUITING Phase 2 42 participants

Nab-Paclitaxel + Cisplatin + Gemcitabine in Untreated Metastatic Pancreatic Adenocarcinoma

HonorHealth Research Institute

NCT03915444

ACTIVE NOT RECRUITING Early Phase 1 30 participants

Imaging Study of 18F-FAC PET Scans to Assess Standard Treatment in People With Pancreatic Cancer

Memorial Sloan Kettering Cancer Center

NCT05141643

ACTIVE NOT RECRUITING Phase 2 29 participants

A Study of Glipizide to Treat High Blood Sugar in People With Pancreatic Cancer

Memorial Sloan Kettering Cancer Center

NCT06168812

ACTIVE NOT RECRUITING Phase 2 28 participants

Enfortumab Vedotin in Previously Treated Locally Advanced or Metastatic Pancreatic Cancer (EPIC)

University of Kansas Medical Center

NCT05915351

ACTIVE NOT RECRUITING Early Phase 1 28 participants

A Feasibility Study of Ketorolac Treatment for Cachexia in Patients With Advanced Pancreatic Ductal Adenocarcinoma

Andrew Hendifar, MD

NCT05336266

ACTIVE NOT RECRUITING Phase 2 24 participants

AGEN1423 and Botensilimab w/ or w/o Chemo in PDAC

Bruno Bockorny

NCT05632328

ACTIVE NOT RECRUITING NA 24 participants

Physical Activity and Nutrition to Halt Elevated Risk in the Pancreas Interception Center

H. Lee Moffitt Cancer Center and Research Institute

NCT06712797

ACTIVE NOT RECRUITING Phase 4 20 participants

Hepatic Artery Chemotherapy for Patients With Localized Pancreas Cancer

Duke University

NCT05634720

ACTIVE NOT RECRUITING Phase 1 18 participants

Vaccine Therapy and Sargramostim in Treating Patients With Pancreas Cancer That Cannot Be Removed By Surgery

National Cancer Institute (NCI)

NCT00669734

ACTIVE NOT RECRUITING Phase 1 16 participants

Ivosidenib + mFOLFIRINOX in Patients With Resectable Pancreatic Adenocarcinoma

Case Comprehensive Cancer Center

NCT05209074

ACTIVE NOT RECRUITING Phase 2 12 participants

ZN-c3 + Gemcitabine in Pancreatic Cancer

Brandon Huffman, MD

NCT06015659

ACTIVE NOT RECRUITING Phase 2 10 participants

The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer

Alliance for Clinical Trials in Oncology

NCT06115499

COMPLETED 300 participants

Utilizing a Multi-gene Testing Approach to Identify Hereditary Pancreatic Cancer

Ambry Genetics

NCT02790944

COMPLETED Phase 1 54 participants

INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors

Incyte Corporation

NCT04580485

COMPLETED 30 participants

CT Pancreas Perfusion

Mayo Clinic

NCT00588367

Phase Distribution

PhaseTrial count
Early Phase 1 47
Phase 2 21
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pancreatic Ductal Adenocarcinoma Trial Landscape

ClinicalTrials.gov lists 85 US studies indexed under Pancreatic Ductal Adenocarcinoma, and 56 of those are currently open to recruitment — roughly 66% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Pancreatic Ductal Adenocarcinoma shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 68 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Pancreatic Ductal Adenocarcinoma is led by AstraZeneca with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 85 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pancreatic Ductal Adenocarcinoma?

PlainTrial tracks 85 US clinical trials for Pancreatic Ductal Adenocarcinoma, of which 56 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pancreatic Ductal Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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