Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07300150 · ClinicalTrials.gov registry record · Phase 1
A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors
A Phase 1 study of Non-Small Cell Lung Cancer and Colorectal Cancer, sponsored by PAQ Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 195
- Enrollment target
- 5
- Study locations
NCT07300150: Recruiting Phase 1 study of Non-Small Cell Lung Cancer and Colorectal Cancer, sponsored by PAQ Therapeutics.
NCT07300150 is a Phase 1 study of Non-Small Cell Lung Cancer and Colorectal Cancer that is actively recruiting participants, run by PAQ Therapeutics. The registered enrollment target is 195 participants, below the 652-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (70% lower). The trial reports 5 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07300150, a Phase 1 study of Non-Small Cell Lung Cancer and Colorectal Cancer, is actively recruiting participants, sponsored by PAQ Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 195 participants
- Enrollment target
- 5
- Study locations
Study Summary
The primary purpose of this study is to evaluate the safety and tolerability, determine the maximally tolerated dose (MTD) and/or recommended Phase 2 dose(s) (RP2D) of PT0511 in adult participants with solid tumors as monotherapy and in combination with cetuximab in participants with colorectal cancer (CRC).
Conditions Studied
Interventions
- DRUG Cetuximab
- DRUG PT0511
Study Locations (5)
Texas
- New Experimental Therapeutics of San Antonio LLC - San Antonio
- START - South Texas Accelerated Research Therapeutics, LLC - San Antonio
Massachusetts
- Dana-Farber/Massachusetts General Hospital, Inc - Boston
Utah
- START Mountain Region - West Valley City
Virginia
- NEXT Virginia - Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 195 participants |
| Start Date | 2025-11-21 |
| Est. Completion | 2028-10-18 |
| Phase | Phase 1 |
What NCT07300150 shows while recruiting
NCT07300150 is an interventional study that assigns participants to a tested intervention. The registered 195 participants enrollment target is mid-sized for trials with a published cap, below the 652-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (70% lower).
The record links to 4 conditions, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 2 interventions - of which Cetuximab is the first listed.
NCT07300150 lists 5 locations in 4 states (Texas, Massachusetts, Utah).
Frequently Asked Questions
What is clinical trial NCT07300150 about?
NCT07300150 is a clinical study titled "A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors". The primary purpose of this study is to evaluate the safety and tolerability, determine the maximally tolerated dose (MTD) and/or recommended Phase 2 dose(s) (RP2D) of PT0511 in adult participants with solid tumors as monotherapy and in combination with cetuximab in participants with colorectal canc...
What is the current status of trial NCT07300150?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 195 participants. The study started on 2025-11-21. Estimated completion is 2028-10-18.
What conditions does trial NCT07300150 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer, Colorectal Cancer, Pancreatic Cancer, Solid Tumor.
What interventions are being tested in trial NCT07300150?
The interventions under investigation include: Cetuximab (DRUG), PT0511 (DRUG).
Who is sponsoring clinical trial NCT07300150?
This trial is sponsored by PAQ Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07300150 being conducted?
This trial has 5 study locations across Massachusetts, Texas, Utah, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Non-Small Cell Lung Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07300150's enrollment target sits among peer trials
195 168th of 454 higher than 287 of 454 other Non-Small Cell Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Non-Small Cell Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Study to Evaluate Safety, Efficacy, and Pharmacokinetics in Participants With Advanced Solid Tumors
RECRUITING · Phase 1
-
A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
RECRUITING · Phase 1
-
Neoadjuvant Dupilumab and Cemiplimab in Patients With Early-stage Resectable NSCLC
RECRUITING · Phase 1
-
A Study Investigating BG-60366 in Adults With Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer
RECRUITING · Phase 1
-
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
RECRUITING · Phase 1
-
A Study of a Selective ERBB2 Inhibitor (CGT4255), in Patients With Advanced Solid Tumors
RECRUITING · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04276922 · 195 participants · NA
Creative Arts Program to Reduce Burnout in Healthcare Professionals
- NCT04829357 · 195 participants
Post Market Clinical Follow-up Study on TVT ABBREVO® Continence System
- NCT05054738 · 195 participants · NA
CRP and S&A for Inpatient Veterans
- NCT05561595 · 195 participants · NA
Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI