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ClinicalTrials.gov 101 recruiting now official registry

Pancreatic Cancer clinical trials

101 of 283 indexed Pancreatic Cancer trials are currently recruiting.

283 US clinical trials · 101 currently recruiting

Pancreatic Cancer is the subject of 283 registered US clinical trials on ClinicalTrials.gov, 101 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 180 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 19 of these trials.

The research picture

Pancreatic Cancer has 283 registered US clinical trials, 101 of them open to new participants right now, about 36% of the total.

101
recruiting participants now
36%
of trials open to enrollment
12
in Phase 3–4 (later-stage)
19
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 1114Phase 266Phase 310Phase 42

Active & Recent Trials

283 total, page 2 of 6

RECRUITING Phase 1 110 participants

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

National Cancer Institute (NCI)

NCT03190941

RECRUITING 105 participants

ESPERANZA: External Control Arm Study for T-DXd for Patients With HER2 IHC3+ Solid Tumors

AstraZeneca

NCT06973161

RECRUITING NA 102 participants

Preoperative Fractionated Radiation Therapy Versus Stereotactic Body Radiation Therapy for Resectable or Borderline Resectable, or Locally Advanced Type A Pancreatic Adenocarcinoma

Medical College of Wisconsin

NCT03704662

RECRUITING 100 participants

Pancreatic Cancer Genetics

Columbia University

NCT01102569

RECRUITING Phase 1 92 participants

AOH1996 for the Treatment of Refractory Solid Tumors

City of Hope Medical Center

NCT05227326

RECRUITING NA 85 participants

A Study of Multiparametric Ultrasound Imaging Methods

Memorial Sloan Kettering Cancer Center

NCT07270237

RECRUITING Phase 2 84 participants

PurIST Classification-Guided Adaptive Neoadjuvant Chemotherapy by RNA Expression Profiling of EUS Aspiration Samples

Medical College of Wisconsin

NCT04683315

RECRUITING Phase 1 80 participants

Initial Feasibility Study to Treat Borderline Resectable Pancreatic Cancer With a Planar LDR Source

CivaTech Oncology

NCT02843945

RECRUITING NA 80 participants

Support Through Remote Observation and Nutrition Guidance Program (STRONG-PCS)

H. Lee Moffitt Cancer Center and Research Institute

NCT06001268

RECRUITING Phase 1 80 participants

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Angiex

NCT06440005

RECRUITING Phase 1 80 participants

First in Human Phase1/2a Clinical Trial of Anti-PAUF Monoclonal Antibody PBP1510 in Patients With Pancreatic Cancer

Prestige Biopharma Limited

NCT05141149

RECRUITING Phase 1 78 participants

IDOV-Immune for Advanced Solid Tumors

ViroMissile

NCT06910657

RECRUITING Phase 1 66 participants

Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

Lumicell

NCT02584244

RECRUITING Phase 2 60 participants

Proton Radiation for Unresectable, Borderline Resectable, or Medically Inoperable Carcinoma of the Pancreas

Proton Collaborative Group

NCT02598349

RECRUITING NA 60 participants

High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies

M.D. Anderson Cancer Center

NCT05053555

RECRUITING NA 60 participants

MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial

Washington University School of Medicine

NCT05975593

RECRUITING NA 55 participants

Disposable Perfusion Phantom for Accurate DCE (Dynamic Contrast Enhanced)-MRI Measurement of Pancreatic Cancer Therapy Response

Ohio State University

NCT04588025

RECRUITING Phase 1 54 participants

KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06411691

RECRUITING Phase 1 51 participants

Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delivered Intraperitoneally for the Management of Platinum Resistant Ovarian Cancer, Mesonephric-like Adenocarcinoma, and Pancreatic Cancer

M.D. Anderson Cancer Center

NCT05922930

RECRUITING Phase 1 51 participants

MK2 Inhibitor in Combination With mFOLFIRINOX for Untreated Metastatic Pancreatic Ductal Adenocarcinoma

Washington University School of Medicine

NCT06648434

RECRUITING Phase 2 46 participants

Study of Amplitude-Modulated Radiofrequency Electromagnetic Fields in Metastatic Pancreatic Cancer

THERABIONIC

NCT05776524

RECRUITING 46 participants

WATD and Cancer-Related Fatigue: A Study For Patients Undergoing Anti-Cancer Treatment

Wake Forest University Health Sciences

NCT06291324

RECRUITING Early Phase 1 46 participants

Lidocaine Infusion in Pancreatic Cancer

University of Illinois at Chicago

NCT04048278

RECRUITING Phase 1 45 participants

Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors

UNC Lineberger Comprehensive Cancer Center

NCT03454035

RECRUITING NA 45 participants

Resistance Exercise Combined With Protein Supplementation in People With Pancreatic Cancer: The RE-BUILD Trial

Dana-Farber Cancer Institute

NCT05356117

RECRUITING Phase 1 40 participants

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Memgen

NCT05076760

RECRUITING Phase 1 38 participants

Comparing Neoadjuvant/Adjuvant GVAX vs a mKRASvax Given With Anti-PD-1 and Anti-CD137 for Surgically Resectable Pancreatic Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06782932

RECRUITING Phase 1 37 participants

Mutant KRAS -Targeted Long Peptide Vaccine for Patients at High Risk of Developing Pancreatic Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05013216

RECRUITING Phase 1 36 participants

A Pilot Study to Assess the Clinical Utility of PYLARIFY PET-CT for Detecting Metastasis in Pancreatic Cancer, Hepatocellular Carcinoma and Breast Cancer

M.D. Anderson Cancer Center

NCT05394259

RECRUITING NA 30 participants

Alpha Radiation Emitters Device for the Treatment of Pancreatic Cancer With Chemotherapy for the Treatment of Locally Advanced and Metastatic Pancreatic Cancer

Alpha Tau Medical

NCT06698458

RECRUITING NA 26 participants

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

Memorial Sloan Kettering Cancer Center

NCT05837767

RECRUITING Phase 1 26 participants

64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

Lantheus Medical Imaging

NCT06298916

RECRUITING Phase 1 26 participants

PTM-101 in Pancreatic Ductal Adenocarcinoma (PDAC)

PanTher Therapeutics

NCT06673017

RECRUITING NA 26 participants

Remote Exercise and Nutritional Prehabilitation for Pancreatic Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT06423963

RECRUITING Phase 2 25 participants

Modulation of the Gut Microbiome With Pembrolizumab Following Chemotherapy in Resectable Pancreatic Cancer

Icahn School of Medicine at Mount Sinai

NCT05462496

RECRUITING Phase 1 25 participants

Intraoperative Radiation Therapy After Stereotactic Body Radiation Therapy and Chemotherapy in Treatment of Pancreatic Adenocarcinoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05141513

RECRUITING Phase 1 24 participants

SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells

General Oncology

NCT04150042

RECRUITING Phase 1 23 participants

Study of EGFRBi Armed Fresh PBMC in Metastatic or Unresectable Pancreatic Cancer

University of Virginia

NCT06479239

RECRUITING Phase 1 21 participants

Onvansertib in Combination With NALIRIFOX for First Line Treatment of Advanced Pancreatic Cancer

University of Kansas Medical Center

NCT06736717

RECRUITING Phase 2 20 participants

NC410 and FOLFIRINOX in Combination With Nivolumab With or Without Ipilimumab in Patients With Untreated Metastatic Pancreatic Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06941857

RECRUITING Phase 1 20 participants

A Study to Evaluate the Safety and Tolerability of SX-682 in Combination With Nivolumab as a Maintenance Therapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

University of Rochester

NCT04477343

RECRUITING Early Phase 1 20 participants

Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer

Cedars-Sinai Medical Center

NCT05086250

RECRUITING Phase 1 18 participants

Th-1 Dendritic Cell Immunotherapy Plus Standard Chemotherapy for Pancreatic Adenocarcinoma

Diakonos Oncology Corporation

NCT04157127

RECRUITING Phase 1 18 participants

Intra-tumoral Mitazalimab (CD40 Antibody) With Irreversible Electroporation (IRE) in Locally Advanced Pancreas Cancer

University of California, San Diego

NCT06205849

RECRUITING Phase 1 15 participants

EUS RFA for Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)

NYU Langone Health

NCT05723107

RECRUITING NA 15 participants

Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

University of California, Irvine

NCT05497531

RECRUITING 12 participants

Endoscopic Radiofrequency Ablation of Celiac Ganglion for Pain Management and Improvement of Quality of Life in Patients With Unresectable Pancreatic Cancer

West Virginia University

NCT05535894

RECRUITING Phase 1 11 participants

Brodalumab in the Treatment of Immune-Related Adverse Events

Brian Henick, MD

NCT06673329

RECRUITING Phase 1 10 participants

A Phase IB Study to Determine the Safety and Tolerability of Canakinumab and Tislelizumab in Combination With Nab-Paclitaxel and Gemcitabine in the Neo-adjuvant Treatment of Patients With Pancreatic Cancer

NYU Langone Health

NCT05984602

RECRUITING Early Phase 1 10 participants

Pilot Study of an Implantable Microdevice for In Situ Evaluation of Drug Response in Patients With Pancreatic Cancer

Northwell Health

NCT07254091

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Phase Distribution

PhaseTrial count
Phase 1 114
Phase 2 66
Phase 3 10
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pancreatic Cancer Trial Landscape

283 indexed Pancreatic Cancer studies · 101 recruiting (36%).

Phase mix: 12 late (III/IV) vs 180 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (19 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pancreatic Cancer?

PlainTrial tracks 283 US clinical trials for Pancreatic Cancer, of which 101 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pancreatic Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.