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ClinicalTrials.gov 66 recruiting now official registry

Obstructive Sleep Apnea clinical trials

66 of 157 indexed Obstructive Sleep Apnea trials are currently recruiting.

157 US clinical trials · 66 currently recruiting

Obstructive Sleep Apnea is the subject of 157 registered US clinical trials on ClinicalTrials.gov, 66 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.

The research picture

Obstructive Sleep Apnea has 157 registered US clinical trials, 66 of them open to new participants right now, about 42% of the total.

66
recruiting participants now
42%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
11
top sponsor: VA Office of Research and Development
Phase 112Phase 214Phase 38Phase 43

Active & Recent Trials

157 total, page 2 of 4

RECRUITING NA 48 participants

Community Health Advocates for Motivating PAP Use in Our Neighborhoods.

University of Miami

NCT06047353

RECRUITING NA 40 participants

App-Based Optimization of Long-Term CPAP Adherence and Quality of Life

Mayo Clinic

NCT06381115

RECRUITING NA 40 participants

Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea

Wayne State University

NCT03736382

RECRUITING NA 40 participants

Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

University of Michigan

NCT05527652

RECRUITING NA 40 participants

Whole Food Plant-based Diet Effect on Obstructive Sleep Apnea

Mayo Clinic

NCT06395181

RECRUITING NA 36 participants

Mandibular Advancement Device and Changes in Nocturia

Fernanda Yanez Regonesi

NCT05562388

RECRUITING Phase 2 36 participants

Medications for Obstructive Sleep Apnea to Improve Cognition in Children With Down Syndrome

University of Arizona

NCT05933603

RECRUITING 30 participants

Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation

University of Chicago

NCT06317701

RECRUITING NA 30 participants

Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through Mandibular Advancement

Washington University School of Medicine

NCT07132307

RECRUITING NA 24 participants

Smart Pillows for Enhancing Sleep Quality

Indiana University

NCT06594627

RECRUITING NA 22 participants

Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness

NYU Langone Health

NCT06698809

RECRUITING NA 20 participants

Preliminary Evaluation of a RCMP to Predict Failure of Maxillomandibular Advancement Surgery for OSA

University of Michigan

NCT03929549

RECRUITING Phase 1 18 participants

Trazodone on OSA Endotypes

Brigham and Women's Hospital

NCT06286189

RECRUITING Phase 1 18 participants

Atomoxetine and DAW2022 on OSA Severity

Brigham and Women's Hospital

NCT05350215

RECRUITING Phase 1 16 participants

Pharmacological Activation of HMN for OSA Aim 2

Brigham and Women's Hospital

NCT03858751

RECRUITING NA 10 participants

Magnetic Apnea Prevention(MAGNAP) Device to Treat Obstructive Sleep Apnea:First-In-Human Study of Feasibility and Safety

Michael Harrison

NCT02431507

ACTIVE NOT RECRUITING 5,000 participants

A Prospective Observational Cohort to Study the Genetics of Obstructive Sleep Apnea and Associated Co-Morbidities

Ulysses Magalang MD

NCT01857427

ACTIVE NOT RECRUITING Phase 3 2,300 participants

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight

Eli Lilly and Company

NCT05929066

ACTIVE NOT RECRUITING Phase 3 1,000 participants

A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight

Eli Lilly and Company

NCT05929079

ACTIVE NOT RECRUITING Phase 2 560 participants

RePOSA-Revealing the Efficacy of IHL-42X Use in Patients With OSA

Incannex Healthcare

NCT06146101

ACTIVE NOT RECRUITING 450 participants

Predictors of De-novo Development of Obstructive Sleep Apnea in Pregnancy

The Miriam Hospital

NCT02917876

ACTIVE NOT RECRUITING 434 participants

Obstructive Sleep Apnea in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation

St. Jude Children's Research Hospital

NCT03361020

ACTIVE NOT RECRUITING 267 participants

Novel physIologiC prEdictors of Positive Airway Pressure Effectiveness

Yale University

NCT05067088

ACTIVE NOT RECRUITING NA 262 participants

Positive Airway Pressure, Sleep Apnea, and the Placenta (PAP-SAP)

The Miriam Hospital

NCT02412696

ACTIVE NOT RECRUITING NA 150 participants

Treating Obstructive Sleep Apnea Using Targeted Hypoglossal Neurostimulation

LivaNova

NCT04950894

ACTIVE NOT RECRUITING NA 127 participants

Inspire® Post-Approval Study / Protocol Number 2014-001

Inspire Medical Systems

NCT02413970

ACTIVE NOT RECRUITING NA 122 participants

Breathing Training for Improving Cardiovascular Health in Older Adults With Sleep Apnea

University of Arizona

NCT04932447

ACTIVE NOT RECRUITING Phase 2 120 participants

Post-Operative Steroids After Sleep Surgery

Medical University of South Carolina

NCT06818981

ACTIVE NOT RECRUITING NA 115 participants

Dual-sided Hypoglossal neRvE stimulAtion for the treatMent of Obstructive Sleep Apnea (DREAM)

Nyxoah S.A.

NCT03868618

ACTIVE NOT RECRUITING NA 81 participants

Validation of Sleep Questionnaires in the Down Syndrome Population

Oregon Health and Science University

NCT03771469

ACTIVE NOT RECRUITING NA 60 participants

Adherence to Health Coaching with Wearable Devices: Enhancing Patient Engagement and Outcomes

Coastal Carolina University

NCT06525337

ACTIVE NOT RECRUITING Phase 3 57 participants

Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea

Inspire Medical Systems

NCT04801771

ACTIVE NOT RECRUITING 30 participants

RPMO2 Oximeter Accuracy During Sleep 1 Trial

ProSomnus Sleep Technologies

NCT07397780

ACTIVE NOT RECRUITING NA 20 participants

Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial

University of California, San Francisco

NCT05920694

ACTIVE NOT RECRUITING NA 20 participants

3D Printer Modified CPAP Mask for Obstructive Sleep Apnea

Beth Israel Deaconess Medical Center

NCT03932383

ACTIVE NOT RECRUITING NA 14 participants

Obstructive Sleep Apnea (OSA) and Sex-Specific Responses to N-acetylcysteine (NAC)

NYU Langone Health

NCT06311045

ACTIVE NOT RECRUITING NA 6 participants

Addressing Sleep Apnea Post-Stroke/TIA

VA Office of Research and Development

NCT04322162

COMPLETED NA 1,873 participants

Impact of Automated Education and Follow-up Mechanisms on Patient Engagement

Kaiser Permanente

NCT02279901

COMPLETED 1,012 participants

World Trade Center (WTC) CHEST

Icahn School of Medicine at Mount Sinai

NCT01466218

COMPLETED NA 744 participants

Asthma and Obstructive Sleep Apnea (OSA)

University of Wisconsin, Madison

NCT01026298

COMPLETED 555 participants

World Trade Center Kidney-Link

Icahn School of Medicine at Mount Sinai

NCT03234530

COMPLETED Phase 3 476 participants

"Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA"

Jazz Pharmaceuticals

NCT02348606

COMPLETED NA 360 participants

Improving the Frequency and Quality of Sleep Apnea Care Management

VA Office of Research and Development

NCT01916655

COMPLETED NA 317 participants

Obstructive Sleep Apnea in World Trade Center Responders

Rutgers, The State University of New Jersey

NCT01753999

COMPLETED 300 participants

Evaluation of Obstructive Sleep Apnea as a Risk Factor for Pulmonary Embolism

Atlantic Health System

NCT00409045

COMPLETED NA 270 participants

Self-Management of Continuous Positive Airway Pressure Settings

VA Office of Research and Development

NCT03536572

COMPLETED 231 participants

A Research Study for Children About Heart Changes and Obstructive Sleep Apnea (OSA)

Children's Hospital Medical Center, Cincinnati

NCT01837459

COMPLETED 217 participants

Patient Perception Questionnaire Validation

Fisher and Paykel Healthcare

NCT02067000

COMPLETED 212 participants

Development and Validation of Pediatric Narcolepsy Patient Reported Outcomes Scale

Boston Children's Hospital

NCT05373979

COMPLETED 200 participants

TipTraQ Home Sleep Test Validation Study, Duke

PranaQ Pte.

NCT06351878

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Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 14
Phase 3 8
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Obstructive Sleep Apnea Trial Landscape

157 indexed Obstructive Sleep Apnea studies · 66 recruiting (42%).

Phase mix: 11 late (III/IV) vs 26 early (I/II).

Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Obstructive Sleep Apnea?

PlainTrial tracks 157 US clinical trials for Obstructive Sleep Apnea, of which 66 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Obstructive Sleep Apnea?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.