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ClinicalTrials.gov 66 recruiting now official registry

Obstructive Sleep Apnea clinical trials

66 of 157 indexed Obstructive Sleep Apnea trials are currently recruiting.

157 US clinical trials · 66 currently recruiting

Obstructive Sleep Apnea is the subject of 157 registered US clinical trials on ClinicalTrials.gov, 66 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.

The research picture

Obstructive Sleep Apnea has 157 registered US clinical trials, 66 of them open to new participants right now, about 42% of the total.

66
recruiting participants now
42%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
11
top sponsor: VA Office of Research and Development
Phase 112Phase 214Phase 38Phase 43

Active & Recent Trials

157 total, page 1 of 4

RECRUITING 1,731 participants

SUNOSI® (Solriamfetol) Pregnancy Registry

Axsome Therapeutics

NCT06413420

RECRUITING 1,500 participants

Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05656365

RECRUITING 800 participants

Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

Beth Israel Deaconess Medical Center

NCT04603196

RECRUITING NA 668 participants

Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)

VA Office of Research and Development

NCT04179981

RECRUITING 600 participants

Obstructive Sleep Apnea Among Somali-Americans

Mayo Clinic

NCT04124848

RECRUITING 500 participants

MicroRNAs as Biomarkers for Obstructive Sleep Apnea

University of Pennsylvania

NCT06189755

RECRUITING NA 400 participants

Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

Seattle Institute for Biomedical and Clinical Research

NCT06390345

RECRUITING NA 360 participants

OurSleepKit To Support CPAP Adherence

National Heart, Lung, and Blood Institute (NHLBI)

NCT06621511

RECRUITING NA 360 participants

The Recovery in Stroke Using PAP Study

Yale University

NCT04130503

RECRUITING NA 303 participants

Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

Oregon Health and Science University

NCT05508971

RECRUITING Phase 1 260 participants

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

University of California, San Diego

NCT05094271

RECRUITING Phase 3 250 participants

Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy

Amgen

NCT07226765

RECRUITING Phase 3 250 participants

Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy

Amgen

NCT07225686

RECRUITING NA 241 participants

DISE: Phenotyping Obstruction Patterns

University of Pennsylvania

NCT05050383

RECRUITING Phase 2 240 participants

The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

University of California, San Diego

NCT05237505

RECRUITING NA 240 participants

Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils

Oregon Health and Science University

NCT06258837

RECRUITING Phase 2 230 participants

Down Syndrome Obstructive Sleep Apnea

Brigham and Women's Hospital

NCT06043440

RECRUITING 227 participants

Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype

Ohio State University

NCT05742360

RECRUITING NA 200 participants

Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy

Emory University

NCT05350332

RECRUITING Phase 2 200 participants

Do Endotypes Predict Response and Sequelae in OSA Patients

University of California, San Diego

NCT04875364

RECRUITING NA 200 participants

The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

California Pacific Medical Center Research Institute

NCT05988385

RECRUITING 200 participants

Predictors of Post-COVID-19 Clinical and Cognitive Consequences

VA Office of Research and Development

NCT06291870

RECRUITING NA 194 participants

OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit

VA Office of Research and Development

NCT05156112

RECRUITING Phase 2 150 participants

Endotypic Traits and Obstructive Sleep Apnea Surgery

University of California, Los Angeles

NCT05953610

RECRUITING NA 140 participants

Cognition After OSA Treatment Among Native American People (CATNAP)

Washington State University

NCT06227572

RECRUITING NA 130 participants

OSA-18 in Children With Mild Obstructive Sleep Apnea: Can it be a Helpful Decision Making Tool?

Connecticut Children's Medical Center

NCT05911646

RECRUITING Phase 1 120 participants

DRonabinol Treatment of OSA

VA Office of Research and Development

NCT06477952

RECRUITING Phase 4 120 participants

Improving Outcomes in Pediatric Obstructive Sleep Apnea With Computational Fluid Dynamics

Children's Hospital Medical Center, Cincinnati

NCT04991389

RECRUITING NA 108 participants

Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD

VA Office of Research and Development

NCT02703207

RECRUITING NA 100 participants

Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation

University of California, San Francisco

NCT07220525

RECRUITING NA 100 participants

Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA

Vanderbilt University Medical Center

NCT05501236

RECRUITING NA 100 participants

Metabolism and Sleep Apnea Treatment

University of Miami

NCT05539716

RECRUITING Phase 2 90 participants

Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea

Erin Kirkham

NCT05303987

RECRUITING NA 86 participants

PAP for Children With DS and OSAS

University of Miami

NCT04132999

RECRUITING Early Phase 1 80 participants

Time Restricted Eating in Sleep Apnea

University of California, San Diego

NCT06047496

RECRUITING 70 participants

Safety and Effectiveness of Slow Wave Device for the Treatment of Obstructive Sleep Apnea

Slow Wave

NCT06519149

RECRUITING NA 70 participants

Alesis OSA-1 Obstructive Sleep Apnea Treatment

Photonica USA

NCT06949969

RECRUITING Phase 1 70 participants

Rescue Pharmacotherapy for OSA

Brigham and Women's Hospital

NCT05293600

RECRUITING Phase 1 60 participants

Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities

VA Office of Research and Development

NCT05558501

RECRUITING Phase 2 60 participants

Patient-centered and Neurocognitive Outcomes with Acetazolamide for Sleep Apnea

University of California, San Diego

NCT05804084

RECRUITING 60 participants

Pediatric Post-Approval Registry

Inspire Medical Systems

NCT04457154

RECRUITING NA 60 participants

Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study

Tulane University

NCT04814420

RECRUITING NA 60 participants

Cardiometabolic Risk Effects of Short-term Cessation of Neurostimulation Therapy

Columbia University

NCT06720545

RECRUITING NA 60 participants

Bright Light Therapy for OSA

VA Office of Research and Development

NCT05917119

RECRUITING NA 60 participants

Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives

Washington University School of Medicine

NCT07074288

RECRUITING 60 participants

A Study of Sex Differences in Neurocirculatory Control

Mayo Clinic

NCT06261034

RECRUITING NA 50 participants

Enhancing PAP Adherence Among Spanish-speaking Hispanic Adults With OSA

Geisinger Clinic

NCT05618444

RECRUITING NA 50 participants

Intraoperative Ansa Cervicalis Nerve (ACN) Stimulation

Vanderbilt University Medical Center

NCT05650710

RECRUITING 50 participants

Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.

Thomas Jefferson University

NCT04191512

RECRUITING NA 49 participants

Severe Label Expansion for EVO Products Trial

ProSomnus Sleep Technologies

NCT07090395

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Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 14
Phase 3 8
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Obstructive Sleep Apnea Trial Landscape

157 indexed Obstructive Sleep Apnea studies · 66 recruiting (42%).

Phase mix: 11 late (III/IV) vs 26 early (I/II).

Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Obstructive Sleep Apnea?

PlainTrial tracks 157 US clinical trials for Obstructive Sleep Apnea, of which 66 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Obstructive Sleep Apnea?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.