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NCT06286189 · ClinicalTrials.gov registry record · Phase 1

Trazodone on OSA Endotypes

A Phase 1 study of Obstructive Sleep Apnea, sponsored by Brigham and Women's Hospital.

Recruiting
Registry status
Phase 1
Development phase
18
Enrollment target
1
Study location

NCT06286189 is a Phase 1 study of Obstructive Sleep Apnea that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 18 participants, below the 221-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06286189, a Phase 1 study of Obstructive Sleep Apnea, is actively recruiting participants, sponsored by Brigham and Women's Hospital.

RECRUITING
Registry status
Phase 1
Development phase
18 participants
Enrollment target
1
Study location

Study Summary

Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. Some OSA patients with low arousal threshold wake up prematurely during an obstructive event and do not have time for spontaneous upper airway (UA) dilator muscle recruitment. As a consequence they are exposed to apnea and hypopnea cycling. In this protocol the investigators will test the effect of trazodone administered before sleep on OSA traits and OSA severity during sleep.

Conditions Studied

Obstructive Sleep Apnea

Interventions

  • DRUG Placebo oral tablet
  • DRUG Trazodone Hydrochloride

Study Locations (1)

Massachusetts

  • Brigham and Women's Hospital - Boston

Trial Details

FieldValue
Enrollment Target 18 participants
Start Date 2024-01-01
Est. Completion 2026-06-01
Phase Phase 1

Sponsor

Brigham and Women's Hospital

937 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06286189

The ClinicalTrials.gov registry entry for NCT06286189 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 18 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 221-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target (92% lower). The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Obstructive Sleep Apnea appearing as the primary indexed condition, and to 2 interventions - of which Placebo oral tablet is the first listed.

NCT06286189 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.

Frequently Asked Questions

What is clinical trial NCT06286189 about?

NCT06286189 is a clinical study titled "Trazodone on OSA Endotypes". Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. Some OSA patients with low arousal threshold wake up prematurely during an obstructive event and do not have time for spontaneous upper airway (UA) dilator muscle recruitment. As a consequenc...

What is the current status of trial NCT06286189?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2024-01-01. Estimated completion is 2026-06-01.

What conditions does trial NCT06286189 study?

This clinical trial studies the following conditions: Obstructive Sleep Apnea.

What interventions are being tested in trial NCT06286189?

The interventions under investigation include: Placebo oral tablet (DRUG), Trazodone Hydrochloride (DRUG).

Who is sponsoring clinical trial NCT06286189?

This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06286189 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.