Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT03858751 · ClinicalTrials.gov registry record · Phase 1

Pharmacological Activation of HMN for OSA Aim 2

A Phase 1 study of Obstructive Sleep Apnea, sponsored by Brigham and Women's Hospital.

Recruiting
Registry status
Phase 1
Development phase
16
Enrollment target
1
Study location

NCT03858751 is a Phase 1 study of Obstructive Sleep Apnea that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 16 participants, below the 221-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT03858751, a Phase 1 study of Obstructive Sleep Apnea, is actively recruiting participants, sponsored by Brigham and Women's Hospital.

RECRUITING
Registry status
Phase 1
Development phase
16 participants
Enrollment target
1
Study location

Study Summary

Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal subjects. In this protocol the investigators will test the effect of LTM1201AZ, LTM1201AT, LTM1201AD, LTM1201AG administered before sleep on OSA phenotype traits and OSA severity during sleep.

Conditions Studied

Obstructive Sleep Apnea

Interventions

  • DRUG Placebo oral capsule
  • DRUG LTM1201AZ
  • DRUG LTM1201AT
  • DRUG LTM1201AG
  • DRUG LTM1201AD

Study Locations (1)

Massachusetts

  • Brigham and Women's Hospital - Boston

Trial Details

FieldValue
Enrollment Target 16 participants
Start Date 2019-03-01
Est. Completion 2022-12-31
Phase Phase 1

Sponsor

Brigham and Women's Hospital

937 total trials

Interested in This Trial?

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03858751

The ClinicalTrials.gov registry entry for NCT03858751 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 16 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 221-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target (93% lower). The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Obstructive Sleep Apnea appearing as the primary indexed condition, and to 5 interventions - of which Placebo oral capsule is the first listed.

NCT03858751 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.

Frequently Asked Questions

What is clinical trial NCT03858751 about?

NCT03858751 is a clinical study titled "Pharmacological Activation of HMN for OSA Aim 2". Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal subjects. In th...

What is the current status of trial NCT03858751?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 16 participants. The study started on 2019-03-01. Estimated completion is 2022-12-31.

What conditions does trial NCT03858751 study?

This clinical trial studies the following conditions: Obstructive Sleep Apnea.

What interventions are being tested in trial NCT03858751?

The interventions under investigation include: Placebo oral capsule (DRUG), LTM1201AZ (DRUG), LTM1201AT (DRUG), LTM1201AG (DRUG), LTM1201AD (DRUG).

Who is sponsoring clinical trial NCT03858751?

This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT03858751 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Obstructive Sleep Apnea

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Explore more on PlainTrial

Obstructive Sleep Apnea

All registered trials for this condition

Massachusetts

All trials with a study site in Massachusetts

Recruiting now

Find trials open to new participants near you

Rankings

Top sponsors, conditions, and phases

Read our methodology - how this data is sourced, computed, and verified.

Related

Browse all → | Rankings →
Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.