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ClinicalTrials.gov 8 recruiting now official registry

Anesthesia, Local clinical trials

Every US clinical trial registered for Anesthesia, Local — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

19 US clinical trials · 8 currently recruiting

The research picture

Anesthesia, Local has 19 registered US clinical trials, 8 of them open to new participants right now — about 42% of the total.

8
recruiting participants now
42%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
2
top sponsor: American Genomics

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 204 participants

Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements

University of California, San Diego

NCT06960317

RECRUITING NA 134 participants

Effect of Fasting on Patient Outcomes After Wide-Awake, Local Anesthesia-only, No Tourniquet (WALANT) Procedures

University of California, Irvine

NCT05819801

RECRUITING NA 80 participants

A Pilot Study of Local Anesthesia for Inguinal Hernia Surgery in Older Adults

University of Wisconsin, Madison

NCT04706026

RECRUITING Phase 4 70 participants

Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection

University of California, San Diego

NCT04849455

RECRUITING NA 66 participants

Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery

University of Massachusetts, Worcester

NCT06528288

RECRUITING NA 50 participants

Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized Molars

University of Michigan

NCT05964387

RECRUITING NA 40 participants

Obstetric Placement Study Using EST

Stanford University

NCT04109365

RECRUITING Phase 4 35 participants

Split Face Study of the Duration of Local Anesthetics - Fourth Arm

Weill Medical College of Cornell University

NCT06694714

ACTIVE NOT RECRUITING 230 participants

Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Vanderbilt University Medical Center

NCT04036305

ACTIVE NOT RECRUITING Phase 4 18 participants

Intralipid® 20% for Reversal of Local Anesthetics

Hospital for Special Surgery, New York

NCT03968822

COMPLETED Phase 4 150 participants

Study of OraVerse® for Safety and Efficacy in Pediatric Dental Patients

Novocol Pharmaceutical of Canada

NCT01474382

COMPLETED Phase 3 120 participants

A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution

American Genomics

NCT04829344

COMPLETED Phase 4 85 participants

Liposomal Bupivacaine Versus Bupivacaine for for Postoperative Pain Control in Shoulder Surgery

Bassett Healthcare

NCT04180943

COMPLETED Phase 3 61 participants

A Study of Safety and the Local Anesthetic Effect of AG-920 Ophthalmic Solution in a Pediatric Population

American Genomics

NCT05325853

COMPLETED Phase 1 40 participants

Cooling Anesthesia for Intravitreal Injection

Recens Medical

NCT03732287

COMPLETED Phase 4 36 participants

Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures

Denver Health and Hospital Authority

NCT03305666

COMPLETED 29 participants

Changes in Tissue Oxygenation Following Regional Anesthesia

Nationwide Children's Hospital

NCT01418690

COMPLETED Phase 4 26 participants

Clinical Trial Comparing Effectiveness of Buffered Versus Unbuffered Local Anesthetic in Children Ages 10-12 Years

University of North Carolina, Chapel Hill

NCT03562481

COMPLETED Early Phase 1 21 participants

Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy

University of Alabama at Birmingham

NCT04019834

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 3 2
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Anesthesia, Local Trial Landscape

ClinicalTrials.gov lists 19 US studies indexed under Anesthesia, Local, and 8 of those are currently open to recruitment — roughly 42% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Anesthesia, Local shows 9 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Anesthesia, Local is led by American Genomics with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 19 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Anesthesia, Local?

PlainTrial tracks 19 US clinical trials for Anesthesia, Local, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Anesthesia, Local?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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