Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Anesthesia, Local clinical trials
Every US clinical trial registered for Anesthesia, Local — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
19 US clinical trials · 8 currently recruiting
The research picture
Anesthesia, Local has 19 registered US clinical trials, 8 of them open to new participants right now — about 42% of the total.
- 8
- recruiting participants now
- 42%
- of trials open to enrollment
- 9
- in Phase 3–4 (later-stage)
- 2
- top sponsor: American Genomics
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements
University of California, San Diego
NCT06960317
Effect of Fasting on Patient Outcomes After Wide-Awake, Local Anesthesia-only, No Tourniquet (WALANT) Procedures
University of California, Irvine
NCT05819801
A Pilot Study of Local Anesthesia for Inguinal Hernia Surgery in Older Adults
University of Wisconsin, Madison
NCT04706026
Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection
University of California, San Diego
NCT04849455
Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery
University of Massachusetts, Worcester
NCT06528288
Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized Molars
University of Michigan
NCT05964387
Obstetric Placement Study Using EST
Stanford University
NCT04109365
Split Face Study of the Duration of Local Anesthetics - Fourth Arm
Weill Medical College of Cornell University
NCT06694714
Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers
Vanderbilt University Medical Center
NCT04036305
Intralipid® 20% for Reversal of Local Anesthetics
Hospital for Special Surgery, New York
NCT03968822
Study of OraVerse® for Safety and Efficacy in Pediatric Dental Patients
Novocol Pharmaceutical of Canada
NCT01474382
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
American Genomics
NCT04829344
Liposomal Bupivacaine Versus Bupivacaine for for Postoperative Pain Control in Shoulder Surgery
Bassett Healthcare
NCT04180943
A Study of Safety and the Local Anesthetic Effect of AG-920 Ophthalmic Solution in a Pediatric Population
American Genomics
NCT05325853
Cooling Anesthesia for Intravitreal Injection
Recens Medical
NCT03732287
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures
Denver Health and Hospital Authority
NCT03305666
Changes in Tissue Oxygenation Following Regional Anesthesia
Nationwide Children's Hospital
NCT01418690
Clinical Trial Comparing Effectiveness of Buffered Versus Unbuffered Local Anesthetic in Children Ages 10-12 Years
University of North Carolina, Chapel Hill
NCT03562481
Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy
University of Alabama at Birmingham
NCT04019834
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 3 | 2 |
| Phase 4 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Anesthesia, Local Trial Landscape
ClinicalTrials.gov lists 19 US studies indexed under Anesthesia, Local, and 8 of those are currently open to recruitment — roughly 42% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Anesthesia, Local shows 9 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Anesthesia, Local is led by American Genomics with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 19 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Anesthesia, Local?
PlainTrial tracks 19 US clinical trials for Anesthesia, Local, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Anesthesia, Local?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.