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ClinicalTrials.gov 8 recruiting now official registry

Anesthesia, Local clinical trials

8 of 19 indexed Anesthesia, Local trials are currently recruiting.

19 US clinical trials · 8 currently recruiting

Anesthesia, Local is the subject of 19 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is American Genomics, running 2 of these trials.

The research picture

Anesthesia, Local has 19 registered US clinical trials, 8 of them open to new participants right now, about 42% of the total.

8
recruiting participants now
42%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
2
top sponsor: American Genomics
Phase 12Phase 32Phase 47

Active & Recent Trials

19 total, page 1 of 1

RECRUITING NA 204 participants

Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements

University of California, San Diego

NCT06960317

RECRUITING NA 134 participants

Effect of Fasting on Patient Outcomes After Wide-Awake, Local Anesthesia-only, No Tourniquet (WALANT) Procedures

University of California, Irvine

NCT05819801

RECRUITING NA 80 participants

A Pilot Study of Local Anesthesia for Inguinal Hernia Surgery in Older Adults

University of Wisconsin, Madison

NCT04706026

RECRUITING Phase 4 70 participants

Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection

University of California, San Diego

NCT04849455

RECRUITING NA 66 participants

Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery

University of Massachusetts, Worcester

NCT06528288

RECRUITING NA 50 participants

Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized Molars

University of Michigan

NCT05964387

RECRUITING NA 40 participants

Obstetric Placement Study Using EST

Stanford University

NCT04109365

RECRUITING Phase 4 35 participants

Split Face Study of the Duration of Local Anesthetics - Fourth Arm

Weill Medical College of Cornell University

NCT06694714

ACTIVE NOT RECRUITING 230 participants

Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Vanderbilt University Medical Center

NCT04036305

ACTIVE NOT RECRUITING Phase 4 18 participants

Intralipid® 20% for Reversal of Local Anesthetics

Hospital for Special Surgery, New York

NCT03968822

COMPLETED Phase 4 150 participants

Study of OraVerse® for Safety and Efficacy in Pediatric Dental Patients

Novocol Pharmaceutical of Canada

NCT01474382

COMPLETED Phase 3 120 participants

A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution

American Genomics

NCT04829344

COMPLETED Phase 4 85 participants

Liposomal Bupivacaine Versus Bupivacaine for for Postoperative Pain Control in Shoulder Surgery

Bassett Healthcare

NCT04180943

COMPLETED Phase 3 61 participants

A Study of Safety and the Local Anesthetic Effect of AG-920 Ophthalmic Solution in a Pediatric Population

American Genomics

NCT05325853

COMPLETED Phase 1 40 participants

Cooling Anesthesia for Intravitreal Injection

Recens Medical

NCT03732287

COMPLETED Phase 4 36 participants

Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures

Denver Health and Hospital Authority

NCT03305666

COMPLETED 29 participants

Changes in Tissue Oxygenation Following Regional Anesthesia

Nationwide Children's Hospital

NCT01418690

COMPLETED Phase 4 26 participants

Clinical Trial Comparing Effectiveness of Buffered Versus Unbuffered Local Anesthetic in Children Ages 10-12 Years

University of North Carolina, Chapel Hill

NCT03562481

COMPLETED Early Phase 1 21 participants

Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy

University of Alabama at Birmingham

NCT04019834

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 3 2
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Anesthesia, Local Trial Landscape

19 indexed Anesthesia, Local studies · 8 recruiting (42%).

Phase mix: 9 late (III/IV) vs 2 early (I/II).

Top sponsor: American Genomics (2 trials), 9 others listed. 19 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Anesthesia, Local?

PlainTrial tracks 19 US clinical trials for Anesthesia, Local, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Anesthesia, Local?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.