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NCT03361020 · ClinicalTrials.gov registry record
Obstructive Sleep Apnea in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation
A clinical trial of Obstructive Sleep Apnea and Hodgkin Lymphoma, sponsored by St. Jude Children's Research Hospital.
- Active
- Registry status
- 434
- Enrollment target
- 1
- Study location
NCT03361020 is a study of Obstructive Sleep Apnea and Hodgkin Lymphoma that is active but no longer recruiting, run by St. Jude Children's Research Hospital. The registered enrollment target is 434 participants, above the 219-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target (98% higher). The trial reports 1 study location across 1 state.
The verdict
NCT03361020, a study of Obstructive Sleep Apnea and Hodgkin Lymphoma, is active but no longer recruiting, sponsored by St. Jude Children's Research Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- 434 participants
- Enrollment target
- 1
- Study location
Study Summary
While thoracic radiation therapy (TRT) has been a primary component in successful treatment of Hodgkin lymphoma, exposure to this treatment has been associated with significant cardiovascular, cerebrovascular, and pulmonary morbidity in long-term survivors. Survivors of Hodgkin lymphoma (HL) are also at risk for fatigue and excessive daytime sleepiness. Insufficient sleep is recognized as an important public health concern, and is associated with cardiovascular disease, diabetes, obesity, neurocognitive problems, and reduced quality of life and productivity. Survivors of HL, who are already at risk for cardiac and neurologic morbidity due to their treatment exposures, could face catastrophic cardiovascular and cerebrovascular events with the added risk associated with obstructive sleep apnea (OSA). The investigators propose to examine indices of sleep quality using polysomnography, and associated neurocognitive performance, brain MRI, and structure and strength of neck muscles in 220 long-term adult survivors of Hodgkin lymphoma treated with thoracic radiation. OBJECTIVES: 1. To estimate the prevalence of OSA in adult survivors of HL treated with thoracic radiation, and compare the frequency to community controls matched on age, gender, race and body mass index. 2. To identify specific therapeutic factors associated with OSA in adult survivors of HL treated with thoracic radiation. 3. To identify biomarkers of OSA in adult survivors of HL treated with thoracic radiation. 4. To examine associations between OSA and cardiac morbidity and brain integrity in the adult survivors of HL treated with thoracic radiation.
Conditions Studied
Study Locations (1)
Tennessee
- St. Jude Children's Research Hospital - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 434 participants |
| Start Date | 2018-01-23 |
| Est. Completion | 2028-07-10 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03361020
The ClinicalTrials.gov registry entry for NCT03361020 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 434 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 219-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target (98% higher). The listed sponsor is St. Jude Children's Research Hospital, which has 410 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Obstructive Sleep Apnea appearing as the primary indexed condition, and to 0 interventions.
NCT03361020 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.
Frequently Asked Questions
What is clinical trial NCT03361020 about?
NCT03361020 is a clinical study titled "Obstructive Sleep Apnea in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation". While thoracic radiation therapy (TRT) has been a primary component in successful treatment of Hodgkin lymphoma, exposure to this treatment has been associated with significant cardiovascular, cerebrovascular, and pulmonary morbidity in long-term survivors. Survivors of Hodgkin lymphoma (HL) are als...
What is the current status of trial NCT03361020?
This trial is currently active not recruiting. The enrollment target is 434 participants. The study started on 2018-01-23. Estimated completion is 2028-07-10.
What conditions does trial NCT03361020 study?
This clinical trial studies the following conditions: Obstructive Sleep Apnea, Hodgkin Lymphoma.
Who is sponsoring clinical trial NCT03361020?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03361020 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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