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Obstructive Sleep Apnea: early-phase trial registry
66 of 157 indexed Obstructive Sleep Apnea trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #70 of 28,707 conditions by registered trial count.
157 US clinical trials · 66 currently recruiting · #70 of 28,707 conditions by registered trial count
Obstructive Sleep Apnea: 157 US clinical trials tracked, 66 recruiting.
Obstructive Sleep Apnea is the subject of 157 registered US clinical trials on ClinicalTrials.gov, 66 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.
Enrollment posture brief
Registry condition obstructive-sleep-apnea
OPEN 66 | RECR 42% | LATE 11 | EARLY 26 | RANK #70 | SPON 11
Volume-matched condition peers
Nearest open-share peer: Anesthesia, Local (42% recruiting · 19 trials)
Obstructive Sleep Apnea lists 66 open slots (42% of 157 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Obstructive Sleep Apnea on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Obstructive Sleep Apnea is recruiting above its size-band peers.
66 of 157 indexed trials (42%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Obstructive Sleep Apnea trials is spread across many organizations.
VA Office of Research and Development accounts for 11 of 157 trials (7%). 96 distinct sponsors appear on at least one study for this condition label.
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Typical Obstructive Sleep Apnea enrolment sits around 76 participants.
Median target enrolment is 76 among the 156 trials that report a genuine target (sentinel values excluded). 85 of those (54.5%) plan for fewer than 100 participants.
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Obstructive Sleep Apnea research is mostly interventional.
123 interventional and 34 observational studies make up this index (78.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
157 total, page 3 of 4
Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing
Somnarus
NCT02034175
Positive Pressure Treatment of Obstructive Sleep Apnea
Philips Respironics
NCT00636181
Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea
Eisai
NCT03471871
Metabolic Impact of Intermittent CPAP
Johns Hopkins University
NCT02824263
Trial of AD036 in Obstructive Sleep Apnea
Apnimed
NCT03845023
Targeted Hypoglossal Neurostimulation Study #3
ImThera Medical
NCT02263859
Promoting Continuous Positive Airway Pressure (CPAP) Adherence
University of Pennsylvania
NCT01335854
Effects of Upper Airway Muscle Training on OSA
University of California, San Diego
NCT02502942
Mechanisms of Upper Airway Obstruction
University of Pennsylvania
NCT04322097
Screening for Sleep Apnea in Patients Undergoing Atrial Fibrillation Ablation
Beth Israel Deaconess Medical Center
NCT02332096
Whitsundays (Nasal) Mask Take Home Study (90 Days)
ResMed
NCT06036329
Screening Tools for Obstructive Sleep Apnea (OSA) in Hospitalized Medical Patients
MetroHealth Medical Center
NCT01340781
Underlying Mechanisms of Obesity-induced Obstructive Sleep Apnea
Brandon Nokes
NCT04793334
A Multi-Center Study to Assess the Performance of Saturation Patterns.
Medtronic - MITG
NCT00775346
Hypnotics to Improve Polysomnography Yield: Eszopiclone vs Ramelteon?
Southern California Institute for Research and Education
NCT00811746
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
VA Office of Research and Development
NCT02641496
Workflow Validation of an In-home Auto-titrating Mandibular Positioner
Zephyr Sleep Technologies
NCT02933112
Assessing the Risk of Developing Type II Diabetes Using Serum Biomarkers in Patients Diagnosed With Obstructive Sleep Apnea
Mike O'Callaghan Military Hospital
NCT01447251
Study of Pantoprazole for Sleepiness Associated With Acid Reflux and Sleep Apnea
University of Cincinnati
NCT00307944
Aspirin Resistance in OSA Patients
Danbury Hospital
NCT03930875
Micro-stream Capnography in Non-intubated Lean and Obese Patients With and Without Obstructive Sleep Apnea
The Cleveland Clinic
NCT00653471
Increasing Adherence to Oral Appliance Therapy for Obstructive Sleep Apnea
Ohio State University
NCT05038215
Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study
Axsome Therapeutics
NCT04789174
The Evaluation of a Mask for the Treatment of Obstructive Sleep Apnea
Fisher and Paykel Healthcare
NCT03142438
Telemedici ne Management of Veterans With Newly Diagnosed Obstructiv e Sleep Apnea (OSA)
Corporal Michael J. Crescenz VA Medical Center
NCT02159885
Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial
University of Pittsburgh
NCT01187771
Effect of Opioids on Ventilation in Children With Obstructive Sleep Apnea
Baylor College of Medicine
NCT03938259
A Pilot Study of Biomarkers in Obstructive Sleep Apnea
Hospital for Special Surgery, New York
NCT02325687
TheraPAP Equivalence Crossover Study
SleepRes
NCT06238362
Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography
Philips Respironics
NCT01175031
Effect of Heated Humidity With Thermosmart™ Compared to an Intranasal Steroid in Improving Compliance and Nasal Symptoms in Patients Using Continuous Positive Airway Pressure
Clayton Sleep Insititute
NCT00665977
Evaluation of the F&P Toffee Nasal Pillows Mask, US, 2022
Fisher and Paykel Healthcare
NCT05573763
Pulse Oximeter for Sleep Evaluation
Stanford University
NCT04612114
Managing Opioid Related Sleep Apnea With Acetazolamide
University of California, San Diego
NCT06043830
The Evaluation of the Toffee Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea
Fisher and Paykel Healthcare
NCT03242148
The Evaluation of a Full Face Mask Seal for the Treatment of Obstructive Sleep Apnea
Fisher and Paykel Healthcare
NCT03230877
Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults
University of Kansas Medical Center
NCT02251574
Stroke and CPAP Outcome Study 3
University of Washington
NCT06029959
Improving Older Adults' Decision Making for OSAT
University of California, Los Angeles
NCT03138993
Efficacy of Clinical Decision Support and Sleep Navigation (Sleep PASS)
Children's Hospital of Philadelphia
NCT05353998
Postoperative Neurocognitive Disorders
Massachusetts General Hospital
NCT04244162
Comparison of Sleep Study Results After Partial Intracapsular Tonsillectomy Versus Total Tonsillectomy
State University of New York - Downstate Medical Center
NCT00887471
Variable Negative External Pressure (vNEP) - An Alternative to Continuous Positive Airway Pressure (CPAP) for the Treatment of Obstructive Sleep Apnea (OSA): A Pilot Study
Somne
NCT04718142
Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation
Breas Medical
NCT06560411
Clinical Study for the BONGO Device in the Treatment of Obstructive Sleep Apnea (OSA)
InnoMed Healthscience
NCT02878590
Effects of Continuous Positive Airway Pressure (CPAP) Treatment on Glucose Control in Patients With Type 2 Diabetes
University of Chicago
NCT01136785
Medications for Obstructive Sleep Apnea In Children With Down Syndrome
University of Arizona
NCT04115878
Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use
ResMed
NCT01462084
US Clinical Study of the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System to Treat Obstructive Sleep Apnea
Apnex Medical
NCT01211444
Lifestyle Interventions for Seniors With Apnea
Johns Hopkins University
NCT01422863
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 12 |
| Phase 2 | 14 |
| Phase 3 | 8 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Obstructive Sleep Apnea records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Obstructive Sleep Apnea trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Obstructive Sleep Apnea page
157 registered trials, 66 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 66 Obstructive Sleep Apnea trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Obstructive Sleep Apnea trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Obstructive Sleep Apnea condition card totals 157 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.