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ClinicalTrials.gov 66 recruiting now official registry

Obstructive Sleep Apnea clinical trials

66 of 157 indexed Obstructive Sleep Apnea trials are currently recruiting.

157 US clinical trials · 66 currently recruiting

Obstructive Sleep Apnea is the subject of 157 registered US clinical trials on ClinicalTrials.gov, 66 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.

The research picture

Obstructive Sleep Apnea has 157 registered US clinical trials, 66 of them open to new participants right now, about 42% of the total.

66
recruiting participants now
42%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
11
top sponsor: VA Office of Research and Development
Phase 112Phase 214Phase 38Phase 43

Active & Recent Trials

157 total, page 3 of 4

COMPLETED NA 190 participants

Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing

Somnarus

NCT02034175

COMPLETED NA 168 participants

Positive Pressure Treatment of Obstructive Sleep Apnea

Philips Respironics

NCT00636181

COMPLETED Phase 1 146 participants

Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea

Eisai

NCT03471871

COMPLETED NA 144 participants

Metabolic Impact of Intermittent CPAP

Johns Hopkins University

NCT02824263

COMPLETED Phase 2 140 participants

Trial of AD036 in Obstructive Sleep Apnea

Apnimed

NCT03845023

COMPLETED NA 138 participants

Targeted Hypoglossal Neurostimulation Study #3

ImThera Medical

NCT02263859

COMPLETED Early Phase 1 135 participants

Promoting Continuous Positive Airway Pressure (CPAP) Adherence

University of Pennsylvania

NCT01335854

COMPLETED NA 134 participants

Effects of Upper Airway Muscle Training on OSA

University of California, San Diego

NCT02502942

COMPLETED NA 133 participants

Mechanisms of Upper Airway Obstruction

University of Pennsylvania

NCT04322097

COMPLETED 130 participants

Screening for Sleep Apnea in Patients Undergoing Atrial Fibrillation Ablation

Beth Israel Deaconess Medical Center

NCT02332096

COMPLETED NA 120 participants

Whitsundays (Nasal) Mask Take Home Study (90 Days)

ResMed

NCT06036329

COMPLETED 110 participants

Screening Tools for Obstructive Sleep Apnea (OSA) in Hospitalized Medical Patients

MetroHealth Medical Center

NCT01340781

COMPLETED 106 participants

Underlying Mechanisms of Obesity-induced Obstructive Sleep Apnea

Brandon Nokes

NCT04793334

COMPLETED 92 participants

A Multi-Center Study to Assess the Performance of Saturation Patterns.

Medtronic - MITG

NCT00775346

COMPLETED NA 90 participants

Hypnotics to Improve Polysomnography Yield: Eszopiclone vs Ramelteon?

Southern California Institute for Research and Education

NCT00811746

COMPLETED NA 76 participants

Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD

VA Office of Research and Development

NCT02641496

COMPLETED NA 71 participants

Workflow Validation of an In-home Auto-titrating Mandibular Positioner

Zephyr Sleep Technologies

NCT02933112

COMPLETED NA 70 participants

Assessing the Risk of Developing Type II Diabetes Using Serum Biomarkers in Patients Diagnosed With Obstructive Sleep Apnea

Mike O'Callaghan Military Hospital

NCT01447251

COMPLETED Phase 4 68 participants

Study of Pantoprazole for Sleepiness Associated With Acid Reflux and Sleep Apnea

University of Cincinnati

NCT00307944

COMPLETED 63 participants

Aspirin Resistance in OSA Patients

Danbury Hospital

NCT03930875

COMPLETED Early Phase 1 60 participants

Micro-stream Capnography in Non-intubated Lean and Obese Patients With and Without Obstructive Sleep Apnea

The Cleveland Clinic

NCT00653471

COMPLETED NA 60 participants

Increasing Adherence to Oral Appliance Therapy for Obstructive Sleep Apnea

Ohio State University

NCT05038215

COMPLETED Phase 4 59 participants

Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study

Axsome Therapeutics

NCT04789174

COMPLETED NA 57 participants

The Evaluation of a Mask for the Treatment of Obstructive Sleep Apnea

Fisher and Paykel Healthcare

NCT03142438

COMPLETED NA 53 participants

Telemedici ne Management of Veterans With Newly Diagnosed Obstructiv e Sleep Apnea (OSA)

Corporal Michael J. Crescenz VA Medical Center

NCT02159885

COMPLETED Phase 2 53 participants

Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial

University of Pittsburgh

NCT01187771

COMPLETED 52 participants

Effect of Opioids on Ventilation in Children With Obstructive Sleep Apnea

Baylor College of Medicine

NCT03938259

COMPLETED NA 50 participants

A Pilot Study of Biomarkers in Obstructive Sleep Apnea

Hospital for Special Surgery, New York

NCT02325687

COMPLETED NA 50 participants

TheraPAP Equivalence Crossover Study

SleepRes

NCT06238362

COMPLETED NA 45 participants

Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography

Philips Respironics

NCT01175031

COMPLETED Phase 3 44 participants

Effect of Heated Humidity With Thermosmart™ Compared to an Intranasal Steroid in Improving Compliance and Nasal Symptoms in Patients Using Continuous Positive Airway Pressure

Clayton Sleep Insititute

NCT00665977

COMPLETED NA 40 participants

Evaluation of the F&P Toffee Nasal Pillows Mask, US, 2022

Fisher and Paykel Healthcare

NCT05573763

COMPLETED 40 participants

Pulse Oximeter for Sleep Evaluation

Stanford University

NCT04612114

COMPLETED Phase 2 39 participants

Managing Opioid Related Sleep Apnea With Acetazolamide

University of California, San Diego

NCT06043830

COMPLETED NA 38 participants

The Evaluation of the Toffee Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea

Fisher and Paykel Healthcare

NCT03242148

COMPLETED 38 participants

The Evaluation of a Full Face Mask Seal for the Treatment of Obstructive Sleep Apnea

Fisher and Paykel Healthcare

NCT03230877

COMPLETED NA 37 participants

Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults

University of Kansas Medical Center

NCT02251574

COMPLETED NA 36 participants

Stroke and CPAP Outcome Study 3

University of Washington

NCT06029959

COMPLETED NA 36 participants

Improving Older Adults' Decision Making for OSAT

University of California, Los Angeles

NCT03138993

COMPLETED NA 33 participants

Efficacy of Clinical Decision Support and Sleep Navigation (Sleep PASS)

Children's Hospital of Philadelphia

NCT05353998

COMPLETED 32 participants

Postoperative Neurocognitive Disorders

Massachusetts General Hospital

NCT04244162

COMPLETED 30 participants

Comparison of Sleep Study Results After Partial Intracapsular Tonsillectomy Versus Total Tonsillectomy

State University of New York - Downstate Medical Center

NCT00887471

COMPLETED NA 28 participants

Variable Negative External Pressure (vNEP) - An Alternative to Continuous Positive Airway Pressure (CPAP) for the Treatment of Obstructive Sleep Apnea (OSA): A Pilot Study

Somne

NCT04718142

COMPLETED NA 23 participants

Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation

Breas Medical

NCT06560411

COMPLETED NA 23 participants

Clinical Study for the BONGO Device in the Treatment of Obstructive Sleep Apnea (OSA)

InnoMed Healthscience

NCT02878590

COMPLETED NA 22 participants

Effects of Continuous Positive Airway Pressure (CPAP) Treatment on Glucose Control in Patients With Type 2 Diabetes

University of Chicago

NCT01136785

COMPLETED Phase 2 22 participants

Medications for Obstructive Sleep Apnea In Children With Down Syndrome

University of Arizona

NCT04115878

COMPLETED NA 21 participants

Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use

ResMed

NCT01462084

COMPLETED Phase 2 20 participants

US Clinical Study of the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System to Treat Obstructive Sleep Apnea

Apnex Medical

NCT01211444

COMPLETED NA 18 participants

Lifestyle Interventions for Seniors With Apnea

Johns Hopkins University

NCT01422863

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Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 14
Phase 3 8
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Obstructive Sleep Apnea Trial Landscape

157 indexed Obstructive Sleep Apnea studies · 66 recruiting (42%).

Phase mix: 11 late (III/IV) vs 26 early (I/II).

Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Obstructive Sleep Apnea?

PlainTrial tracks 157 US clinical trials for Obstructive Sleep Apnea, of which 66 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Obstructive Sleep Apnea?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.