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Obstructive Sleep Apnea clinical trials
66 of 157 indexed Obstructive Sleep Apnea trials are currently recruiting.
157 US clinical trials · 66 currently recruiting
Obstructive Sleep Apnea is the subject of 157 registered US clinical trials on ClinicalTrials.gov, 66 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.
The research picture
Obstructive Sleep Apnea has 157 registered US clinical trials, 66 of them open to new participants right now, about 42% of the total.
- 66
- recruiting participants now
- 42%
- of trials open to enrollment
- 11
- in Phase 3–4 (later-stage)
- 11
- top sponsor: VA Office of Research and Development
Active & Recent Trials
157 total, page 3 of 4
Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing
Somnarus
NCT02034175
Positive Pressure Treatment of Obstructive Sleep Apnea
Philips Respironics
NCT00636181
Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea
Eisai
NCT03471871
Metabolic Impact of Intermittent CPAP
Johns Hopkins University
NCT02824263
Trial of AD036 in Obstructive Sleep Apnea
Apnimed
NCT03845023
Targeted Hypoglossal Neurostimulation Study #3
ImThera Medical
NCT02263859
Promoting Continuous Positive Airway Pressure (CPAP) Adherence
University of Pennsylvania
NCT01335854
Effects of Upper Airway Muscle Training on OSA
University of California, San Diego
NCT02502942
Mechanisms of Upper Airway Obstruction
University of Pennsylvania
NCT04322097
Screening for Sleep Apnea in Patients Undergoing Atrial Fibrillation Ablation
Beth Israel Deaconess Medical Center
NCT02332096
Whitsundays (Nasal) Mask Take Home Study (90 Days)
ResMed
NCT06036329
Screening Tools for Obstructive Sleep Apnea (OSA) in Hospitalized Medical Patients
MetroHealth Medical Center
NCT01340781
Underlying Mechanisms of Obesity-induced Obstructive Sleep Apnea
Brandon Nokes
NCT04793334
A Multi-Center Study to Assess the Performance of Saturation Patterns.
Medtronic - MITG
NCT00775346
Hypnotics to Improve Polysomnography Yield: Eszopiclone vs Ramelteon?
Southern California Institute for Research and Education
NCT00811746
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
VA Office of Research and Development
NCT02641496
Workflow Validation of an In-home Auto-titrating Mandibular Positioner
Zephyr Sleep Technologies
NCT02933112
Assessing the Risk of Developing Type II Diabetes Using Serum Biomarkers in Patients Diagnosed With Obstructive Sleep Apnea
Mike O'Callaghan Military Hospital
NCT01447251
Study of Pantoprazole for Sleepiness Associated With Acid Reflux and Sleep Apnea
University of Cincinnati
NCT00307944
Aspirin Resistance in OSA Patients
Danbury Hospital
NCT03930875
Micro-stream Capnography in Non-intubated Lean and Obese Patients With and Without Obstructive Sleep Apnea
The Cleveland Clinic
NCT00653471
Increasing Adherence to Oral Appliance Therapy for Obstructive Sleep Apnea
Ohio State University
NCT05038215
Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study
Axsome Therapeutics
NCT04789174
The Evaluation of a Mask for the Treatment of Obstructive Sleep Apnea
Fisher and Paykel Healthcare
NCT03142438
Telemedici ne Management of Veterans With Newly Diagnosed Obstructiv e Sleep Apnea (OSA)
Corporal Michael J. Crescenz VA Medical Center
NCT02159885
Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial
University of Pittsburgh
NCT01187771
Effect of Opioids on Ventilation in Children With Obstructive Sleep Apnea
Baylor College of Medicine
NCT03938259
A Pilot Study of Biomarkers in Obstructive Sleep Apnea
Hospital for Special Surgery, New York
NCT02325687
TheraPAP Equivalence Crossover Study
SleepRes
NCT06238362
Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography
Philips Respironics
NCT01175031
Effect of Heated Humidity With Thermosmart™ Compared to an Intranasal Steroid in Improving Compliance and Nasal Symptoms in Patients Using Continuous Positive Airway Pressure
Clayton Sleep Insititute
NCT00665977
Evaluation of the F&P Toffee Nasal Pillows Mask, US, 2022
Fisher and Paykel Healthcare
NCT05573763
Pulse Oximeter for Sleep Evaluation
Stanford University
NCT04612114
Managing Opioid Related Sleep Apnea With Acetazolamide
University of California, San Diego
NCT06043830
The Evaluation of the Toffee Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea
Fisher and Paykel Healthcare
NCT03242148
The Evaluation of a Full Face Mask Seal for the Treatment of Obstructive Sleep Apnea
Fisher and Paykel Healthcare
NCT03230877
Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults
University of Kansas Medical Center
NCT02251574
Stroke and CPAP Outcome Study 3
University of Washington
NCT06029959
Improving Older Adults' Decision Making for OSAT
University of California, Los Angeles
NCT03138993
Efficacy of Clinical Decision Support and Sleep Navigation (Sleep PASS)
Children's Hospital of Philadelphia
NCT05353998
Postoperative Neurocognitive Disorders
Massachusetts General Hospital
NCT04244162
Comparison of Sleep Study Results After Partial Intracapsular Tonsillectomy Versus Total Tonsillectomy
State University of New York - Downstate Medical Center
NCT00887471
Variable Negative External Pressure (vNEP) - An Alternative to Continuous Positive Airway Pressure (CPAP) for the Treatment of Obstructive Sleep Apnea (OSA): A Pilot Study
Somne
NCT04718142
Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation
Breas Medical
NCT06560411
Clinical Study for the BONGO Device in the Treatment of Obstructive Sleep Apnea (OSA)
InnoMed Healthscience
NCT02878590
Effects of Continuous Positive Airway Pressure (CPAP) Treatment on Glucose Control in Patients With Type 2 Diabetes
University of Chicago
NCT01136785
Medications for Obstructive Sleep Apnea In Children With Down Syndrome
University of Arizona
NCT04115878
Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use
ResMed
NCT01462084
US Clinical Study of the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System to Treat Obstructive Sleep Apnea
Apnex Medical
NCT01211444
Lifestyle Interventions for Seniors With Apnea
Johns Hopkins University
NCT01422863
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 12 |
| Phase 2 | 14 |
| Phase 3 | 8 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Obstructive Sleep Apnea Trial Landscape
157 indexed Obstructive Sleep Apnea studies · 66 recruiting (42%).
Phase mix: 11 late (III/IV) vs 26 early (I/II).
Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Obstructive Sleep Apnea?
PlainTrial tracks 157 US clinical trials for Obstructive Sleep Apnea, of which 66 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Obstructive Sleep Apnea?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.