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Obesity: early-phase trial registry
306 of 1,057 indexed Obesity trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #3 of 28,707 conditions by registered trial count.
1,057 US clinical trials · 306 currently recruiting · #3 of 28,707 conditions by registered trial count
Obesity: 1,057 US clinical trials tracked, 306 recruiting.
Obesity is the subject of 1,057 registered US clinical trials on ClinicalTrials.gov, 306 of them currently open to new participants. 107 are in Phase 3-4 (later-stage) and 196 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 48 of these trials.
Enrollment posture brief
Registry condition obesity
OPEN 306 | RECR 29% | LATE 107 | EARLY 196 | RANK #3 | SPON 48
Volume-matched condition peers
Nearest open-share peer: Metastatic Pancreatic Adenocarcinoma (29% recruiting · 38 trials)
Obesity lists 306 open slots (29% of 1,057 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Obesity on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Obesity is recruiting below its size-band peers.
306 of 1,057 indexed trials (28.9%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Obesity trials is spread across many organizations.
Eli Lilly and Company accounts for 48 of 1,057 trials (4.5%). 314 distinct sponsors appear on at least one study for this condition label.
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Typical Obesity enrolment sits around 90 participants.
Median target enrolment is 90 among the 1,054 trials that report a genuine target (sentinel values excluded). 555 of those (52.7%) plan for fewer than 100 participants.
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Obesity research is mostly interventional.
894 interventional and 163 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
1,057 total, page 17 of 22
Effect of Conjugated Linoleic Acid Supplement on Body Composition
University of North Carolina
NCT00347373
Feelings About Exercise
The Miriam Hospital
NCT03598647
Cognitive Therapy for Binge-Eating Disorder
University of North Carolina, Chapel Hill
NCT00050037
Low Fat Vegan or American Heart Association Diets & Cardiovascular Risk in Obese 9-18 y.o. With Elevated Cholesterol
The Cleveland Clinic
NCT01817491
Assessment of Changes in Abdominal Fat
Indiana University
NCT00228579
Adipokines Effect in Myometrial Contractility
University of Minnesota
NCT03505541
Diet, Eating, and Lifestyle Improvement for Valued Employees and Their Relatives
University of Pennsylvania
NCT03277040
Characterization of Hyperparathyroidism and Vitamin D Deficiency in Obesity
Weill Medical College of Cornell University
NCT00288873
Modulation of Esophageal Inflammation in Barrett's Esophagus by Omega-3 Fatty Acids
Mayo Clinic
NCT01733147
Progressive Weight Loss and Metabolic Health
Washington University School of Medicine
NCT01299519
Insulin Resistance and Reward
VA Office of Research and Development
NCT02241603
Fruit and Vegetable Prescription Program
Beth Comerford
NCT04072757
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People
Mayo Clinic
NCT04158375
Variability of Physical Assessments in an Older Population That is Overweight or Obese
Versanis Bio
NCT05174923
Effect of Resvida, a Comparison With Calorie Restriction Regimen
Washington University School of Medicine
NCT00823381
Improving Diabetes Outcomes Through Lifestyle Change (IDOLc)Study
Massachusetts General Hospital
NCT01665989
Biologic Effects of Dehydroepiandrosterone (DHEA) in Humans
National Institute on Aging (NIA)
NCT00099697
NT-proBNP Levels and Obesity in Pregnancy
Duke University
NCT04049136
The Childhood Health and Asthma Management Program
University of Florida
NCT02303561
A Multiple Health Behavior Change Intervention for Overweight and Obese Smokers
Brown University
NCT05136430
Clinical Outcomes, Nutritional Status, Exercise and Psychosocial Factors in Pediatric Hematopoietic Cell Transplant
University of Michigan Rogel Cancer Center
NCT02734797
Evaluation of Liver and Cardiometabolic Health Benefits on Low Carbohydrate Ketogenic Diet
Virginia Commonwealth University
NCT03141008
To Investigate the Safety, Tolerability and Pharmacodynamics of GSK2890457 in Healthy Volunteers and Subjects With Type 2 Diabetes
GlaxoSmithKline
NCT01725126
Varying the Energy Density and Portion Size of the Main Course After a First-course Salad
Penn State University
NCT01729390
The Effects of Yoga on Body Image in College Women
University of Delaware
NCT03262350
Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial
University of Pittsburgh
NCT01187771
Study of Low Level Laser Therapy to Reduce Body Circumference in Obese Individuals
Erchonia Corporation
NCT01821352
Mindfulness Training to Promote Healthy Diet and Physical Activity in Teens
University of Massachusetts, Worcester
NCT01975896
Effects of Exercise Training Intensity on Fitness and Insulin Sensitivity in African Americans
East Carolina University
NCT02892331
Seasonal Patterns of Stress, Diet and Physical Activity - Life in All Seasons (LENAS)
USDA Grand Forks Human Nutrition Research Center
NCT01674296
Motivational Interviewing for Weight Loss With Young Adults
Virginia Commonwealth University
NCT01899625
Ghrelin Regulation and Structure: Effect of Diet Composition on Ghrelin
Oregon Health and Science University
NCT00694512
Diet, Imaging and Energy Balance Trial (DIET)
Duke University
NCT00787280
Effect of Vitamin D3 Supplementation on Insulin Resistance and Cardiovascular Risk Factors in Obese Adolescents
Mayo Clinic
NCT00858247
Effects of Pitavastatin on Insulin Sensitivity and Liver Fat
Massachusetts General Hospital
NCT02290106
Rheumatoid Arthritis Coping Enhancement
Duke University
NCT04246827
Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00862433
Randomized Trial Comparing Laparoscopic Roux-en-y Gastric Bypass to Micro-laparoscopic Roux-en-y Gastric Bypass
Suzanne J. Rose
NCT01183273
Gender- and Culturally-Sensitive Weight Loss Intervention for Hispanic Males
University of Arizona
NCT02783521
Effect of Obesity on Immune Response to Pneumovax 23
University of Florida
NCT02471014
Multiple Ascending Dose Study of AMG 598 in Adults With Obesity
Amgen
NCT03757130
Functional MRI of Stress in Obesity
Yale University
NCT01719484
MPOWERed Messages: Tailored Mobile Messages to Enhance Weight Loss for Teens
University of Michigan
NCT01448551
Pilot Behavioral Support Intervention After Bariatric Surgery
Geisinger Clinic
NCT03092479
A Multi-Center Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Body Composition and Metabolic Parameters With Diet and Exercise in Conjunction With Treatment With 12.5 mg or 25 mg Enclomiphene
Repros Therapeutics
NCT02651688
Exercise as a Buffer Against Stress-induced Overeating
The Miriam Hospital
NCT02936076
Oxidative Stress in Asthma
Bastiaan Driehuys
NCT04512547
Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity
Pennington Biomedical Research Center
NCT00936130
Regulation of Muscle Protein Phenotype in Humans With Obesity
Mayo Clinic
NCT04700800
Eating Mindfully to Prevent Weight Regain
University of Utah
NCT04847843
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 95 |
| Phase 2 | 101 |
| Phase 3 | 69 |
| Phase 4 | 38 |
Top Sponsors
Named interventions
Most-linked intervention names on Obesity records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Obesity trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Obesity page
1,057 registered trials, 306 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 306 Obesity trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Eli Lilly and Company sponsors the most Obesity trials on record, review their full trial history before evaluating a specific study. See Eli Lilly and Company's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Obesity condition card totals 1,057 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.