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NCT04700800 · ClinicalTrials.gov registry record · NA
Regulation of Muscle Protein Phenotype in Humans With Obesity
A NA study of Obesity, sponsored by Mayo Clinic.
- Completed
- Registry status
- NA
- Development phase
- 48
- Enrollment target
- 1
- Study location
NCT04700800: Completed NA study of Obesity, sponsored by Mayo Clinic.
NCT04700800 is a NA study of Obesity that has completed, run by Mayo Clinic. The registered enrollment target is 48 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04700800, a NA study of Obesity, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- NA
- Development phase
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
A hallmark of muscle changes in obesity is an altered muscle fiber type profile, characterized by a reduced proportion of Type I fibers - a shift associated with adverse obesity-related health outcomes. This alteration can be linked to changes in the expression of myosin heavy chain (MHC) protein isoforms in the skeletal muscle of individuals with obesity. The investigators aim to modulate the metabolism of muscle MHC isoforms to uncover the biological mechanisms underlying this disrupted expression pattern in muscle of humans with obesity.
Primary Outcome
Protein synthesis rates in whole muscle were quantified as the fractional synthesis rate (FSR), expressed as %/hour - representing the percentage of the entire muscle protein pool newly synthesized per hour. Protein synthesis rates were determined by continuous infusion of a stable isotope-labeled amino acid tracer, followed by measurement of tracer incorporation into the muscle proteins over time. Changes in FSR from baseline were evaluated in response to combined exercise and amino acid infu
Conditions Studied
Interventions
- OTHER Exercise
Study Locations (1)
Arizona
- Mayo Clinic in Arizona - Scottsdale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2021-10-07 |
| Est. Completion | 2024-10-02 |
| Phase | NA |
What the finished NCT04700800 record still lists
NCT04700800 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Obesity appearing as the primary indexed condition, and to 1 intervention - of which Exercise is the first listed.
NCT04700800 reports a single indexed study location in Arizona.
Frequently Asked Questions
What is clinical trial NCT04700800 about?
NCT04700800 is a clinical study titled "Regulation of Muscle Protein Phenotype in Humans With Obesity". A hallmark of muscle changes in obesity is an altered muscle fiber type profile, characterized by a reduced proportion of Type I fibers - a shift associated with adverse obesity-related health outcomes. This alteration can be linked to changes in the expression of myosin heavy chain (MHC) protein is...
What is the current status of trial NCT04700800?
This trial is currently completed. It is a NA study. The enrollment target is 48 participants. The study started on 2021-10-07. Estimated completion is 2024-10-02.
What conditions does trial NCT04700800 study?
This clinical trial studies the following conditions: Obesity.
What interventions are being tested in trial NCT04700800?
The interventions under investigation include: Exercise (OTHER).
Who is sponsoring clinical trial NCT04700800?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04700800 being conducted?
This trial has 1 study location across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04700800's enrollment target sits among peer trials
48 734th of 1053 higher than 312 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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