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NCT00304018 · ClinicalTrials.gov registry record · Phase 1
Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer
A Phase 1 study of Lymphoma and Leukemia, sponsored by University of California, San Francisco.
- Completed
- Registry status
- Phase 1
- Development phase
- 5
- Enrollment target
- 1
- Study location
NCT00304018: Completed Phase 1 study of Lymphoma and Leukemia, sponsored by University of California, San Francisco.
NCT00304018 is a Phase 1 study of Lymphoma and Leukemia that has completed, run by University of California, San Francisco. The registered enrollment target is 5 participants, below the 484-participant average among 299 other Lymphoma trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00304018, a Phase 1 study of Lymphoma and Leukemia, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 5 participants
- Enrollment target
- 1
- Study location
Study Summary
RATIONALE: Giving chemotherapy, such as fludarabine, busulfan, and etoposide, before a donor umbilical cord blood stem cell transplant helps stop the growth of cancer cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving antithymocyte globulin before transplant and tacrolimus and prednisone after transplant may stop this from happening. PURPOSE: This phase I trial is studying how well donor umbilical cord blood transplant works in treating patients with advanced hematologic cancer.
Primary Outcome
Determine the safety and feasibility of performing donor umbilical cord blood transplantation (UCBT) in patients with advanced hematologic malignancies, in terms of \> 80% engraftment rate at day 100 post-transplant and ≤ 50% transplant-related mortality.
Conditions Studied
Interventions
- DRUG fludarabine phosphate
- DRUG etoposide
- DRUG busulfan
- BIOLOGICAL anti-thymocyte globulin
- BIOLOGICAL sargramostim
Study Locations (1)
California
- UCSF Helen Diller Family Comprehensive Cancer Center - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2002-10 |
| Est. Completion | 2009-03 |
| Phase | Phase 1 |
What the finished NCT00304018 record still lists
NCT00304018 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 484-participant average among 299 other Lymphoma trials with a reported enrollment target (99% lower).
The record links to 4 conditions, with Lymphoma appearing as the primary indexed condition, and to 5 interventions - of which fludarabine phosphate is the first listed.
NCT00304018 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT00304018 about?
NCT00304018 is a clinical study titled "Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer". RATIONALE: Giving chemotherapy, such as fludarabine, busulfan, and etoposide, before a donor umbilical cord blood stem cell transplant helps stop the growth of cancer cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells,...
What is the current status of trial NCT00304018?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 5 participants. The study started on 2002-10. Estimated completion is 2009-03.
What conditions does trial NCT00304018 study?
This clinical trial studies the following conditions: Lymphoma, Leukemia, Myelodysplastic Syndromes, Multiple Myeloma and Plasma Cell Neoplasm.
What interventions are being tested in trial NCT00304018?
The interventions under investigation include: fludarabine phosphate (DRUG), etoposide (DRUG), busulfan (DRUG), anti-thymocyte globulin (BIOLOGICAL), sargramostim (BIOLOGICAL).
Who is sponsoring clinical trial NCT00304018?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00304018 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00304018's enrollment target sits among peer trials
5 289th of 299 higher than 9 of 299 other Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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