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Multiple Sclerosis clinical trials
120 of 317 indexed Multiple Sclerosis trials are currently recruiting.
317 US clinical trials · 120 currently recruiting
Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.
The research picture
Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.
- 120
- recruiting participants now
- 38%
- of trials open to enrollment
- 41
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Biogen
Active & Recent Trials
317 total, page 2 of 7
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
University of Alabama at Birmingham
NCT03759522
Functional Balance Intervention in Multiple Sclerosis
University of Illinois at Chicago
NCT06341023
A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
NCT06220201
Obesity and Pediatric Multiple Sclerosis
University of Virginia
NCT04593082
Factorial Optimization Trial to Test Cognitive Behavioral Therapy Components for Multiple Sclerosis Fatigue
University of Washington
NCT06809192
Home Based Infusions for Ocrelizumab
University of Colorado, Denver
NCT04650321
A Study of the MIND Diet for Persons With Multiple Sclerosis
Icahn School of Medicine at Mount Sinai
NCT06992115
Intestinal Immunity in Neurologic Disease
Yale University
NCT06329453
People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists
Northwestern University
NCT07207148
Non-invasive BCI-controlled Assistive Devices
University of Texas at Austin
NCT05183152
Examining the Effects of a Remotely-delivered, Racially-tailored Exercise Training Program for Immediate and Sustained Improvements in Walking Dysfunction, Symptoms, and Health-related Quality of Life (HRQOL) Among African-Americans With Multiple Sclerosis (MS) Residing in Rural Environments.
University of Illinois at Chicago
NCT05516537
Comparing Telehealth-Delivered CBT-I to Web-Based CBT-I to Enhance Sleep, Reduce Fatigue, and Promote Neuroprotection
University of Kansas Medical Center
NCT06434571
This Study Involves a Positron Emission Tomography (PET) Scan Using a New Investigational Radioactive Tracer, [18F]-FZTA, to Detect Inflammation in the Brain. The Tracer Will be Tested in Healthy Younger Adults and Individuals With Multiple Sclerosis.
Washington University School of Medicine
NCT07115017
Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension
University of Massachusetts, Boston
NCT06554340
A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis
Kessler Foundation
NCT06197685
Home Based Functional Balance Intervention for Multiple Sclerosis
University of Illinois at Chicago
NCT07355387
Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis
University of Kansas Medical Center
NCT06428006
A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101
Kyverna Therapeutics
NCT07403188
Study to Investigate Vagus Nerve Stimulation Paired With Motor Task for Remyelination and Functional Recovery
University of Colorado, Denver
NCT06641271
A Study to Evaluate the Safety, Tolerability, Cellular Kinetics, and Pharmacodynamics of P-CD19CD20-ALLO1 in Participants With Multiple Sclerosis
Genentech
NCT07008378
An Individualized-health eLibrary App for People With Multiple Sclerosis
University of Illinois at Urbana-Champaign
NCT05124600
Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects
Massachusetts General Hospital
NCT04699747
Reducing Fatigue in People With Multiple Sclerosis by Treatment With TENS
University of Colorado, Boulder
NCT05500963
Blood Flow Restriction And Veterans With MS
VA Office of Research and Development
NCT05433103
Glucose Consumption in MS Using [F-18]FDG-PET
Brigham and Women's Hospital
NCT07087106
Effect of a Fasting Mimicking Diet on Patients With Multiple Sclerosis (FMDMS)
University of Southern California
NCT06515782
Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis
MGH Institute of Health Professions
NCT06136728
Solriamfetol for the Treatment of Multiple Sclerosis Fatigue
Johns Hopkins University
NCT06170970
Central Vein Sign in Multiple Sclerosis Extension Study
The Cleveland Clinic
NCT07424027
Effects of Torso Weighting on Muscle Activation During Balance Tests in Individuals With and Without Multiple Sclerosis
University of St. Augustine for Health Sciences
NCT06981013
Promotion of Exercise Through Physical Therapy for Multiple Sclerosis: A Pilot Study
University of Michigan
NCT06933160
Ublituximab (Briumvi) for Early Forms of Relapsing Multiple Sclerosis
Northwestern University
NCT07225361
Testing the Feasibility of Computer-based Cognitive Training in Individuals with Multiple Sclerosis Living in the Community
Kessler Foundation
NCT06608797
Remote Evaluation of MIND Diet
University of Illinois at Urbana-Champaign
NCT06450977
Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis
Shirley Ryan AbilityLab
NCT06516458
Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis
Tr1X
NCT07477639
Nomad P-KAFO Study
Shirley Ryan AbilityLab
NCT05644522
Eccentric Exercise and Fatigue in Multiple Sclerosis
Hunter College of City University of New York
NCT06505421
A Study to Evaluate the Safety, Tolerability, and Exploratory Efficacy of IMS001 in Subjects With Multiple Sclerosis
ImStem Biotechnology
NCT04956744
Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)
State University of New York at Buffalo
NCT06463743
Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues
University of Chicago
NCT06171152
Effect of Cooling on Balance Performance in Multiple Sclerosis
Hunter College of City University of New York
NCT06094855
Assessment of Synaptic Density in MS
Brigham and Women's Hospital
NCT04634994
Noninvasive Vagal Nerve Stimulation
NYU Langone Health
NCT06816004
Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02784210
User-friendliness of a Portable Driving Simulator
University of Kansas Medical Center
NCT03969927
Effectiveness of Task Specific Home Exercise Program
New York Presbyterian Brooklyn Methodist Hospital
NCT06486116
Neuromodulating Cortical Regions Involved in Neurogenic Bladder in MS
The Methodist Hospital Research Institute
NCT06072703
Smoldering Inflammation in MS
Washington University School of Medicine
NCT06591429
Dry Needling in Multiple Sclerosis
University of Kansas Medical Center
NCT06394310
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 33 |
| Phase 3 | 24 |
| Phase 4 | 17 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Multiple Sclerosis Trial Landscape
317 indexed Multiple Sclerosis studies · 120 recruiting (38%).
Phase mix: 41 late (III/IV) vs 74 early (I/II).
Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Multiple Sclerosis?
PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Multiple Sclerosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.