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ClinicalTrials.gov 120 recruiting now official registry

Multiple Sclerosis clinical trials

120 of 317 indexed Multiple Sclerosis trials are currently recruiting.

317 US clinical trials · 120 currently recruiting

Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.

The research picture

Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.

120
recruiting participants now
38%
of trials open to enrollment
41
in Phase 3–4 (later-stage)
13
top sponsor: Biogen
Phase 141Phase 233Phase 324Phase 417

Active & Recent Trials

317 total, page 2 of 7

RECRUITING Phase 1 120 participants

Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

University of Alabama at Birmingham

NCT03759522

RECRUITING NA 120 participants

Functional Balance Intervention in Multiple Sclerosis

University of Illinois at Chicago

NCT06341023

RECRUITING Phase 1 120 participants

A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

NCT06220201

RECRUITING 116 participants

Obesity and Pediatric Multiple Sclerosis

University of Virginia

NCT04593082

RECRUITING NA 112 participants

Factorial Optimization Trial to Test Cognitive Behavioral Therapy Components for Multiple Sclerosis Fatigue

University of Washington

NCT06809192

RECRUITING Phase 4 110 participants

Home Based Infusions for Ocrelizumab

University of Colorado, Denver

NCT04650321

RECRUITING NA 100 participants

A Study of the MIND Diet for Persons With Multiple Sclerosis

Icahn School of Medicine at Mount Sinai

NCT06992115

RECRUITING 100 participants

Intestinal Immunity in Neurologic Disease

Yale University

NCT06329453

RECRUITING 100 participants

People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists

Northwestern University

NCT07207148

RECRUITING NA 100 participants

Non-invasive BCI-controlled Assistive Devices

University of Texas at Austin

NCT05183152

RECRUITING NA 100 participants

Examining the Effects of a Remotely-delivered, Racially-tailored Exercise Training Program for Immediate and Sustained Improvements in Walking Dysfunction, Symptoms, and Health-related Quality of Life (HRQOL) Among African-Americans With Multiple Sclerosis (MS) Residing in Rural Environments.

University of Illinois at Chicago

NCT05516537

RECRUITING Phase 2 90 participants

Comparing Telehealth-Delivered CBT-I to Web-Based CBT-I to Enhance Sleep, Reduce Fatigue, and Promote Neuroprotection

University of Kansas Medical Center

NCT06434571

RECRUITING 80 participants

This Study Involves a Positron Emission Tomography (PET) Scan Using a New Investigational Radioactive Tracer, [18F]-FZTA, to Detect Inflammation in the Brain. The Tracer Will be Tested in Healthy Younger Adults and Individuals With Multiple Sclerosis.

Washington University School of Medicine

NCT07115017

RECRUITING NA 80 participants

Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

University of Massachusetts, Boston

NCT06554340

RECRUITING NA 78 participants

A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

Kessler Foundation

NCT06197685

RECRUITING NA 75 participants

Home Based Functional Balance Intervention for Multiple Sclerosis

University of Illinois at Chicago

NCT07355387

RECRUITING Phase 2 70 participants

Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis

University of Kansas Medical Center

NCT06428006

RECRUITING 70 participants

A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101

Kyverna Therapeutics

NCT07403188

RECRUITING NA 70 participants

Study to Investigate Vagus Nerve Stimulation Paired With Motor Task for Remyelination and Functional Recovery

University of Colorado, Denver

NCT06641271

RECRUITING Phase 1 60 participants

A Study to Evaluate the Safety, Tolerability, Cellular Kinetics, and Pharmacodynamics of P-CD19CD20-ALLO1 in Participants With Multiple Sclerosis

Genentech

NCT07008378

RECRUITING NA 60 participants

An Individualized-health eLibrary App for People With Multiple Sclerosis

University of Illinois at Urbana-Champaign

NCT05124600

RECRUITING Phase 1 60 participants

Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects

Massachusetts General Hospital

NCT04699747

RECRUITING NA 60 participants

Reducing Fatigue in People With Multiple Sclerosis by Treatment With TENS

University of Colorado, Boulder

NCT05500963

RECRUITING NA 58 participants

Blood Flow Restriction And Veterans With MS

VA Office of Research and Development

NCT05433103

RECRUITING Phase 4 50 participants

Glucose Consumption in MS Using [F-18]FDG-PET

Brigham and Women's Hospital

NCT07087106

RECRUITING NA 50 participants

Effect of a Fasting Mimicking Diet on Patients With Multiple Sclerosis (FMDMS)

University of Southern California

NCT06515782

RECRUITING Phase 4 48 participants

Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis

MGH Institute of Health Professions

NCT06136728

RECRUITING Phase 2 46 participants

Solriamfetol for the Treatment of Multiple Sclerosis Fatigue

Johns Hopkins University

NCT06170970

RECRUITING NA 40 participants

Central Vein Sign in Multiple Sclerosis Extension Study

The Cleveland Clinic

NCT07424027

RECRUITING NA 40 participants

Effects of Torso Weighting on Muscle Activation During Balance Tests in Individuals With and Without Multiple Sclerosis

University of St. Augustine for Health Sciences

NCT06981013

RECRUITING NA 40 participants

Promotion of Exercise Through Physical Therapy for Multiple Sclerosis: A Pilot Study

University of Michigan

NCT06933160

RECRUITING Phase 4 40 participants

Ublituximab (Briumvi) for Early Forms of Relapsing Multiple Sclerosis

Northwestern University

NCT07225361

RECRUITING NA 40 participants

Testing the Feasibility of Computer-based Cognitive Training in Individuals with Multiple Sclerosis Living in the Community

Kessler Foundation

NCT06608797

RECRUITING NA 40 participants

Remote Evaluation of MIND Diet

University of Illinois at Urbana-Champaign

NCT06450977

RECRUITING 40 participants

Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis

Shirley Ryan AbilityLab

NCT06516458

RECRUITING Phase 1 39 participants

Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis

Tr1X

NCT07477639

RECRUITING NA 36 participants

Nomad P-KAFO Study

Shirley Ryan AbilityLab

NCT05644522

RECRUITING 30 participants

Eccentric Exercise and Fatigue in Multiple Sclerosis

Hunter College of City University of New York

NCT06505421

RECRUITING Phase 1 30 participants

A Study to Evaluate the Safety, Tolerability, and Exploratory Efficacy of IMS001 in Subjects With Multiple Sclerosis

ImStem Biotechnology

NCT04956744

RECRUITING Phase 2 30 participants

Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)

State University of New York at Buffalo

NCT06463743

RECRUITING Early Phase 1 30 participants

Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues

University of Chicago

NCT06171152

RECRUITING 30 participants

Effect of Cooling on Balance Performance in Multiple Sclerosis

Hunter College of City University of New York

NCT06094855

RECRUITING Early Phase 1 30 participants

Assessment of Synaptic Density in MS

Brigham and Women's Hospital

NCT04634994

RECRUITING NA 30 participants

Noninvasive Vagal Nerve Stimulation

NYU Langone Health

NCT06816004

RECRUITING Phase 2 30 participants

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02784210

RECRUITING NA 30 participants

User-friendliness of a Portable Driving Simulator

University of Kansas Medical Center

NCT03969927

RECRUITING NA 30 participants

Effectiveness of Task Specific Home Exercise Program

New York Presbyterian Brooklyn Methodist Hospital

NCT06486116

RECRUITING NA 29 participants

Neuromodulating Cortical Regions Involved in Neurogenic Bladder in MS

The Methodist Hospital Research Institute

NCT06072703

RECRUITING 25 participants

Smoldering Inflammation in MS

Washington University School of Medicine

NCT06591429

RECRUITING NA 24 participants

Dry Needling in Multiple Sclerosis

University of Kansas Medical Center

NCT06394310

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Phase Distribution

PhaseTrial count
Phase 1 41
Phase 2 33
Phase 3 24
Phase 4 17

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Multiple Sclerosis Trial Landscape

317 indexed Multiple Sclerosis studies · 120 recruiting (38%).

Phase mix: 41 late (III/IV) vs 74 early (I/II).

Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Multiple Sclerosis?

PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Multiple Sclerosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.