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NCT04593082 · ClinicalTrials.gov registry record
Obesity and Pediatric Multiple Sclerosis
A clinical trial of Multiple Sclerosis, sponsored by University of Virginia.
- Recruiting
- Registry status
- 116
- Enrollment target
- 2
- Study locations
NCT04593082: Recruiting study of Multiple Sclerosis, sponsored by University of Virginia.
NCT04593082 is a study of Multiple Sclerosis that is actively recruiting participants, run by University of Virginia. The registered enrollment target is 116 participants, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (80% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04593082, a study of Multiple Sclerosis, is actively recruiting participants, sponsored by University of Virginia.
- RECRUITING
- Registry status
- 116 participants
- Enrollment target
- 2
- Study locations
Study Summary
Obesity is one possible contributor to severity of multiple sclerosis and progression of the disease. We already know that obesity is a risk determinant for acquiring MS, yet the impact of obesity on pediatric MS disease expression and course is unknown. This study will evaluate the relationship between obesity, obesity-derived inflammatory mediators, and imaging metrics of MS severity in children. Understanding how childhood obesity contributes to MS severity/progression may yield fundamental insights into disease pathobiology - which may thereby lead to effective strategies for halting its progression in its earliest stages.
Primary Outcome
58 patients with a recent MS diagnosis, stratified by weight category (29 normal weight and 29 overweight/obese). Subjects will undergo MRI to quantify total brain and lesion volume. Z-scores for volumetrics will be determined using age- and sex-matched normative data from the NIH-sponsored ABCD dataset. We will compare mean Z-scores of whole brain volume and focal demyelinating lesion volumes between the two groups.
Conditions Studied
Study Locations (2)
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Virginia
- University of Virginia - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 116 participants |
| Start Date | 2021-06-03 |
| Est. Completion | 2025-06-01 |
What NCT04593082 shows while recruiting
NCT04593082 is an observational study that tracks outcomes without assigning an intervention. The registered 116 participants enrollment target is mid-sized for trials with a published cap, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (80% lower).
The record links to 1 condition, with Multiple Sclerosis appearing as the primary indexed condition, and to 0 interventions.
NCT04593082 reports a single indexed study location in Pennsylvania, Virginia.
Frequently Asked Questions
What is clinical trial NCT04593082 about?
NCT04593082 is a clinical study titled "Obesity and Pediatric Multiple Sclerosis". Obesity is one possible contributor to severity of multiple sclerosis and progression of the disease. We already know that obesity is a risk determinant for acquiring MS, yet the impact of obesity on pediatric MS disease expression and course is unknown. This study will evaluate the relationship bet...
What is the current status of trial NCT04593082?
This trial is currently recruiting. The enrollment target is 116 participants. The study started on 2021-06-03. Estimated completion is 2025-06-01.
What conditions does trial NCT04593082 study?
This clinical trial studies the following conditions: Multiple Sclerosis.
Who is sponsoring clinical trial NCT04593082?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04593082 being conducted?
This trial has 2 study locations across Pennsylvania, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Sclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04593082's enrollment target sits among peer trials
116 120th of 315 higher than 196 of 315 other Multiple Sclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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