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NCT06816004 · ClinicalTrials.gov registry record · NA

Noninvasive Vagal Nerve Stimulation

A NA study of Multiple Sclerosis, sponsored by NYU Langone Health.

Recruiting
Registry status
NA
Development phase
30
Enrollment target
1
Study location

NCT06816004 is a NA study of Multiple Sclerosis that is actively recruiting participants, run by NYU Langone Health. The registered enrollment target is 30 participants, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06816004, a NA study of Multiple Sclerosis, is actively recruiting participants, sponsored by NYU Langone Health.

RECRUITING
Registry status
NA
Development phase
30 participants
Enrollment target
1
Study location

Study Summary

Growing evidence suggests that vagal nerve stimulation (VNS) may be novel and effective in the management of the symptom burden of multiple sclerosis (MS) potentially by reducing inflammation and emotional distress, therefore improving overall well-being. We will complete a pilot study comparing transcutaneous auricular vagus nerve stimulation (taVNS) and transcutaneous cervical vagus nerve stimulation (tcVNS) to a standard intervention of dorsolateral prefrontal cortex (DLPFC) transcranial direct current stimulation (tDCS) as an active control. The primary outcome will be feasibility and the preliminary efficacy data concerning self-reported symptom reduction to inform the design of an intervention, and estimated power needed to complete a larger sham-controlled RCT. We will also measure heart rate variability (HRV), an easily obtained biomarker of vagus nerve stimulation (VNS), in correspondence to intervention response.

Conditions Studied

Multiple Sclerosis

Interventions

  • DEVICE Remotely Supervised Transcranial Direct Current Stimulation (RS - tDCS)
  • DEVICE Remotely Supervised Transcutaneous Auricular Vagus Nerve Stimulation (RS - taVNS)
  • DEVICE Remotely Supervised Transcutaneous Cervical Vagus Nerve Stimulation (RS - tcVNS)

Study Locations (1)

New York

  • NYU Langone Health - New York

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2025-08-20
Est. Completion 2026-05-05
Phase NA

Sponsor

NYU Langone Health

1,164 total trials

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What the Registry Record Tells You About NCT06816004

The ClinicalTrials.gov registry entry for NCT06816004 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (95% lower). The listed sponsor is NYU Langone Health, which has 1,164 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Multiple Sclerosis appearing as the primary indexed condition, and to 3 interventions - of which Remotely Supervised Transcranial Direct Current Stimulation (RS - tDCS) is the first listed.

NCT06816004 reports 1 study location spanning 1 distinct geographic area - top geographies include New York.

Frequently Asked Questions

What is clinical trial NCT06816004 about?

NCT06816004 is a clinical study titled "Noninvasive Vagal Nerve Stimulation". Growing evidence suggests that vagal nerve stimulation (VNS) may be novel and effective in the management of the symptom burden of multiple sclerosis (MS) potentially by reducing inflammation and emotional distress, therefore improving overall well-being. We will complete a pilot study comparing tr...

What is the current status of trial NCT06816004?

This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2025-08-20. Estimated completion is 2026-05-05.

What conditions does trial NCT06816004 study?

This clinical trial studies the following conditions: Multiple Sclerosis.

What interventions are being tested in trial NCT06816004?

The interventions under investigation include: Remotely Supervised Transcranial Direct Current Stimulation (RS - tDCS) (DEVICE), Remotely Supervised Transcutaneous Auricular Vagus Nerve Stimulation (RS - taVNS) (DEVICE), Remotely Supervised Transcutaneous Cervical Vagus Nerve Stimulation (RS - tcVNS) (DEVICE).

Who is sponsoring clinical trial NCT06816004?

This trial is sponsored by NYU Langone Health, which has 1,164 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06816004 being conducted?

This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.