Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis

NCT07477639 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this clinical trial is to treat male and female participants with two types of Multiple Sclerosis (MS) called primary progressive or secondary progressive MS. The main questions the trial aims to answer are the following: * Is TRX319 safe when administered to patients with progressive forms of MS? * At what dose does TRX319 work the best to treat participants with primary and or secondary progressive MS? * Is pre-conditioning (with Bendamustine) needed to allow TRX319 to better treat participants with primary and/or secondary progressive MS? Participants will be asked to be on study for up 1 year and may receive up to 3 total administrations of TRX319. While on study, participants will have blood tests and other assessments (MRI scans and lumbar punctures) done to understand the safety of TRX319 and how it may benefit their multiple sclerosis.

Interventions

  • DRUG Bendamustine
  • BIOLOGICAL TRX319

Study Locations (2)

Kansas

  • University of Kansas Medical Center — Kansas City

Missouri

  • Washington University, St. Louis — St Louis

Trial Details

FieldValue
Enrollment Target 39 participants
Start Date 2026-03
Est. Completion 2029-01
Phase Phase 1

Sponsor

Tr1X

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07477639

The ClinicalTrials.gov registry entry for NCT07477639 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 39 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Tr1X, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Multiple Sclerosis appearing as the primary indexed condition, and to 2 interventions — of which Bendamustine is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07477639 reports 2 study locations spanning 2 distinct geographic areas — top geographies include Kansas, Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07477639 about?

NCT07477639 is a clinical study titled "Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis". The goal of this clinical trial is to treat male and female participants with two types of Multiple Sclerosis (MS) called primary progressive or secondary progressive MS. The main questions the trial aims to answer are the following: * Is TRX319 safe when administered to patients with progressive ...

What is the current status of trial NCT07477639?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 39 participants. The study started on 2026-03. Estimated completion is 2029-01.

What conditions does trial NCT07477639 study?

This clinical trial studies the following conditions: Multiple Sclerosis, Multiple Sclerosis (MS) Primary Progressive, Primary Progressive Multiple Sclerosis, Multiple Sclerosis (MS) Secondary Progressive, Secondary Progressive Multiple Sclerosis (SPMS). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07477639?

The interventions under investigation include: Bendamustine (DRUG), TRX319 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07477639?

This trial is sponsored by Tr1X, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07477639 being conducted?

This trial has 2 study locations across Kansas, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial