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ClinicalTrials.gov 120 recruiting now official registry

Multiple Sclerosis clinical trials

120 of 317 indexed Multiple Sclerosis trials are currently recruiting.

317 US clinical trials · 120 currently recruiting

Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.

The research picture

Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.

120
recruiting participants now
38%
of trials open to enrollment
41
in Phase 3–4 (later-stage)
13
top sponsor: Biogen
Phase 141Phase 233Phase 324Phase 417

Active & Recent Trials

317 total, page 3 of 7

RECRUITING Phase 1 24 participants

An Open-label Study of AZD0120 in Adults With Multiple Sclerosis

AstraZeneca

NCT07224373

RECRUITING NA 24 participants

Meeting an Unmet Need in Multiple Sclerosis

Kessler Foundation

NCT05953519

RECRUITING NA 24 participants

Exercise Rehabilitation Program in MS Who Use Wheelchairs as a Primary Mobility Device

University of Illinois at Chicago

NCT06410261

RECRUITING NA 22 participants

Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS

Shirley Ryan AbilityLab

NCT06390930

RECRUITING NA 21 participants

Intermittent Hypoxia in Persons With Multiple Sclerosis

Shirley Ryan AbilityLab

NCT06276634

RECRUITING Phase 4 20 participants

Concentration of Ofatumumab in the Breast Milk of Lactating Women With Relapsing Forms of Multiple Sclerosis

Novartis Pharmaceuticals

NCT06444113

RECRUITING Early Phase 1 20 participants

Entire-body PET Scans for Multiple Sclerosis

Brain Health Alliance

NCT04390009

RECRUITING NA 20 participants

Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis

University of Illinois at Chicago

NCT06264336

RECRUITING Phase 1 19 participants

Molecular Imaging of NET Using [C-11]MRB-PET in MS

Brigham and Women's Hospital

NCT03207464

RECRUITING Phase 1 15 participants

Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy

National Institute of Neurological Disorders and Stroke (NINDS)

NCT05849467

RECRUITING NA 15 participants

Task Specific Training for Advanced Multiple Sclerosis

Hunter College of City University of New York

NCT06506929

RECRUITING NA 15 participants

Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain

Shirley Ryan AbilityLab

NCT07132775

RECRUITING NA 14 participants

Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis

Cionic

NCT05964829

RECRUITING NA 13 participants

Deciphering Preserved Autonomic Function After Multiple Sclerosis

Mayo Clinic

NCT07012135

RECRUITING Phase 1 12 participants

Vancomycin Study in Multiple Sclerosis (MS)

Icahn School of Medicine at Mount Sinai

NCT05539729

RECRUITING Phase 1 12 participants

A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosis

Stanford University

NCT06138132

RECRUITING 12 participants

Acceptability and Feasibility of Transcranial Magnetic Stimulation (TMS) for Depression in Multiple Sclerosis

University of Utah

NCT06329414

RECRUITING NA 10 participants

Investigating the Effects of Wearable Robotic Exoskeleton for Improving Mobility and Cognition in Persons With MS

Kessler Foundation

NCT04855825

RECRUITING Phase 1 4 participants

Non-invasive Electrical Spinal Cord Stimulation To Restore Upper Extremity Function in Multiple Sclerosis

University of Washington

NCT06552611

RECRUITING NA 3 participants

ECoG BMI for Motor and Speech Control

Karunesh Ganguly

NCT03698149

ACTIVE NOT RECRUITING 10,500 participants

A Study to Evaluate Long-Term Safety of Vumerity and Tecfidera in Participants With Multiple Sclerosis (MS)

Biogen

NCT05767736

ACTIVE NOT RECRUITING 3,226 participants

Biobank For MS And Other Demyelinating Diseases

Accelerated Cure Project for Multiple Sclerosis

NCT00445367

ACTIVE NOT RECRUITING 2,961 participants

A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Multiple Sclerosis and Their Infants

Bristol-Myers Squibb

NCT06133049

ACTIVE NOT RECRUITING Phase 3 1,300 participants

A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis

Hoffmann-La Roche

NCT05269004

ACTIVE NOT RECRUITING Phase 3 1,121 participants

Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis

Immunic

NCT05134441

ACTIVE NOT RECRUITING Phase 3 864 participants

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)

Hoffmann-La Roche

NCT04544436

ACTIVE NOT RECRUITING Phase 3 769 participants

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)

Hoffmann-La Roche

NCT04548999

ACTIVE NOT RECRUITING Phase 2 450 participants

Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients With Progressive Multiple Sclerosis

Immunic

NCT05054140

ACTIVE NOT RECRUITING 420 participants

Central Vein Sign: a Diagnostic Biomarker in Multiple Sclerosis

The Cleveland Clinic

NCT04495556

ACTIVE NOT RECRUITING 400 participants

A Study Utilising Data From European Union (EU) National Multiple Sclerosis (MS) Registries to Assess the Incidence of Anti-Natalizumab Antibody Among Participants Who Receive Subcutaneous Administration of Natalizumab for Treatment of Relapsing-remitting Multiple Sclerosis (RRMS)

Biogen

NCT05925049

ACTIVE NOT RECRUITING 400 participants

Evaluating the Immune Response to COVID19 Vaccination in Immunodeficient Patients

Yale University

NCT05286242

ACTIVE NOT RECRUITING NA 336 participants

MS-DETECT: Early Detection of Multiple Sclerosis Progression With MSCopilot® Detect

Ad scientiam

NCT05816122

ACTIVE NOT RECRUITING 320 participants

Stratification of Risks of Conversion of Radiologically Isolated Syndromes (RIS) by Identifying Biomarkers in Serum and Cerebrospinal Fluid.

Centre Hospitalier Universitaire de Nīmes

NCT06395662

ACTIVE NOT RECRUITING 300 participants

Optimizing Detection and Prediction of Changes in Cognitive Function in Multiple Sclerosis (MS)

University of Michigan

NCT05252195

ACTIVE NOT RECRUITING NA 280 participants

Project BIPAMS: Behavioral Intervention for Physical Activity in Multiple Sclerosis

University of Alabama at Birmingham

NCT03490240

ACTIVE NOT RECRUITING Phase 3 240 participants

Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis

Novartis Pharmaceuticals

NCT01892722

ACTIVE NOT RECRUITING NA 150 participants

The Use of Technology to Improve MS Clinical Trials and Patient Care

Johns Hopkins University

NCT02454907

ACTIVE NOT RECRUITING 150 participants

Portable Neuromodulation Stimulator Registry for People With Multiple Sclerosis

Helius Medical

NCT06930339

ACTIVE NOT RECRUITING Phase 2 129 participants

Proof-of-concept Study for SAR441344 (Frexalimab) in Relapsing Multiple Sclerosis

Sanofi

NCT04879628

ACTIVE NOT RECRUITING NA 120 participants

VIRtual Versus UsuAL In-office Care for Multiple Sclerosis (VIRTUAL-MS)

The Cleveland Clinic

NCT05660187

ACTIVE NOT RECRUITING Phase 2 120 participants

KYSA-7: A Study of Anti-CD19 CAR T-Cell Therapy, in Subjects With Refractory Primary and Secondary Progressive Multiple Sclerosis

Kyverna Therapeutics

NCT06384976

ACTIVE NOT RECRUITING NA 120 participants

Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in MS

Kessler Foundation

NCT03983681

ACTIVE NOT RECRUITING NA 100 participants

Multiple Sclerosis Falls Insight Track

University of California, San Francisco

NCT05837949

ACTIVE NOT RECRUITING NA 100 participants

A Closed Loop, Doctor to Patient, Mobile Application for Depression in People With Multiple Sclerosis

University of California, San Francisco

NCT05865405

ACTIVE NOT RECRUITING Phase 2 98 participants

Neuroprotection With N-acetyl Cysteine for Patients With Progressive Multiple Sclerosis

Emmanuelle Waubant, MD PhD

NCT05122559

ACTIVE NOT RECRUITING 90 participants

A Novel Wearable Digital Biomarker for Detecting Changes in Multiple Sclerosis (MS) Condition

Celestra Health Systems

NCT05781113

ACTIVE NOT RECRUITING NA 90 participants

TRAIN-BW: Backward Walking Training in Multiple Sclerosis

Wayne State University

NCT04091464

ACTIVE NOT RECRUITING NA 60 participants

MSCopilot Users' Feedback in Real Life - Outcomes Regarding Integration in Patients' pathWay and Users' ExpeRience

Ad scientiam

NCT06922942

ACTIVE NOT RECRUITING NA 60 participants

Home Based Tele-exercise for People With Chronic Neurological Impairments

Burke Medical Research Institute

NCT04564495

ACTIVE NOT RECRUITING NA 60 participants

A Health Action Process Approach Online Intervention for People With Multiple Sclerosis

University of Illinois at Urbana-Champaign

NCT05124522

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Phase Distribution

PhaseTrial count
Phase 1 41
Phase 2 33
Phase 3 24
Phase 4 17

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Multiple Sclerosis Trial Landscape

317 indexed Multiple Sclerosis studies · 120 recruiting (38%).

Phase mix: 41 late (III/IV) vs 74 early (I/II).

Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Multiple Sclerosis?

PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Multiple Sclerosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.