Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Multiple Sclerosis clinical trials
120 of 317 indexed Multiple Sclerosis trials are currently recruiting.
317 US clinical trials · 120 currently recruiting
Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.
The research picture
Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.
- 120
- recruiting participants now
- 38%
- of trials open to enrollment
- 41
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Biogen
Active & Recent Trials
317 total, page 3 of 7
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
AstraZeneca
NCT07224373
Meeting an Unmet Need in Multiple Sclerosis
Kessler Foundation
NCT05953519
Exercise Rehabilitation Program in MS Who Use Wheelchairs as a Primary Mobility Device
University of Illinois at Chicago
NCT06410261
Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS
Shirley Ryan AbilityLab
NCT06390930
Intermittent Hypoxia in Persons With Multiple Sclerosis
Shirley Ryan AbilityLab
NCT06276634
Concentration of Ofatumumab in the Breast Milk of Lactating Women With Relapsing Forms of Multiple Sclerosis
Novartis Pharmaceuticals
NCT06444113
Entire-body PET Scans for Multiple Sclerosis
Brain Health Alliance
NCT04390009
Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis
University of Illinois at Chicago
NCT06264336
Molecular Imaging of NET Using [C-11]MRB-PET in MS
Brigham and Women's Hospital
NCT03207464
Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT05849467
Task Specific Training for Advanced Multiple Sclerosis
Hunter College of City University of New York
NCT06506929
Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain
Shirley Ryan AbilityLab
NCT07132775
Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis
Cionic
NCT05964829
Deciphering Preserved Autonomic Function After Multiple Sclerosis
Mayo Clinic
NCT07012135
Vancomycin Study in Multiple Sclerosis (MS)
Icahn School of Medicine at Mount Sinai
NCT05539729
A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosis
Stanford University
NCT06138132
Acceptability and Feasibility of Transcranial Magnetic Stimulation (TMS) for Depression in Multiple Sclerosis
University of Utah
NCT06329414
Investigating the Effects of Wearable Robotic Exoskeleton for Improving Mobility and Cognition in Persons With MS
Kessler Foundation
NCT04855825
Non-invasive Electrical Spinal Cord Stimulation To Restore Upper Extremity Function in Multiple Sclerosis
University of Washington
NCT06552611
ECoG BMI for Motor and Speech Control
Karunesh Ganguly
NCT03698149
A Study to Evaluate Long-Term Safety of Vumerity and Tecfidera in Participants With Multiple Sclerosis (MS)
Biogen
NCT05767736
Biobank For MS And Other Demyelinating Diseases
Accelerated Cure Project for Multiple Sclerosis
NCT00445367
A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Multiple Sclerosis and Their Infants
Bristol-Myers Squibb
NCT06133049
A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
Hoffmann-La Roche
NCT05269004
Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis
Immunic
NCT05134441
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)
Hoffmann-La Roche
NCT04544436
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
Hoffmann-La Roche
NCT04548999
Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients With Progressive Multiple Sclerosis
Immunic
NCT05054140
Central Vein Sign: a Diagnostic Biomarker in Multiple Sclerosis
The Cleveland Clinic
NCT04495556
A Study Utilising Data From European Union (EU) National Multiple Sclerosis (MS) Registries to Assess the Incidence of Anti-Natalizumab Antibody Among Participants Who Receive Subcutaneous Administration of Natalizumab for Treatment of Relapsing-remitting Multiple Sclerosis (RRMS)
Biogen
NCT05925049
Evaluating the Immune Response to COVID19 Vaccination in Immunodeficient Patients
Yale University
NCT05286242
MS-DETECT: Early Detection of Multiple Sclerosis Progression With MSCopilot® Detect
Ad scientiam
NCT05816122
Stratification of Risks of Conversion of Radiologically Isolated Syndromes (RIS) by Identifying Biomarkers in Serum and Cerebrospinal Fluid.
Centre Hospitalier Universitaire de Nīmes
NCT06395662
Optimizing Detection and Prediction of Changes in Cognitive Function in Multiple Sclerosis (MS)
University of Michigan
NCT05252195
Project BIPAMS: Behavioral Intervention for Physical Activity in Multiple Sclerosis
University of Alabama at Birmingham
NCT03490240
Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis
Novartis Pharmaceuticals
NCT01892722
The Use of Technology to Improve MS Clinical Trials and Patient Care
Johns Hopkins University
NCT02454907
Portable Neuromodulation Stimulator Registry for People With Multiple Sclerosis
Helius Medical
NCT06930339
Proof-of-concept Study for SAR441344 (Frexalimab) in Relapsing Multiple Sclerosis
Sanofi
NCT04879628
VIRtual Versus UsuAL In-office Care for Multiple Sclerosis (VIRTUAL-MS)
The Cleveland Clinic
NCT05660187
KYSA-7: A Study of Anti-CD19 CAR T-Cell Therapy, in Subjects With Refractory Primary and Secondary Progressive Multiple Sclerosis
Kyverna Therapeutics
NCT06384976
Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in MS
Kessler Foundation
NCT03983681
Multiple Sclerosis Falls Insight Track
University of California, San Francisco
NCT05837949
A Closed Loop, Doctor to Patient, Mobile Application for Depression in People With Multiple Sclerosis
University of California, San Francisco
NCT05865405
Neuroprotection With N-acetyl Cysteine for Patients With Progressive Multiple Sclerosis
Emmanuelle Waubant, MD PhD
NCT05122559
A Novel Wearable Digital Biomarker for Detecting Changes in Multiple Sclerosis (MS) Condition
Celestra Health Systems
NCT05781113
TRAIN-BW: Backward Walking Training in Multiple Sclerosis
Wayne State University
NCT04091464
MSCopilot Users' Feedback in Real Life - Outcomes Regarding Integration in Patients' pathWay and Users' ExpeRience
Ad scientiam
NCT06922942
Home Based Tele-exercise for People With Chronic Neurological Impairments
Burke Medical Research Institute
NCT04564495
A Health Action Process Approach Online Intervention for People With Multiple Sclerosis
University of Illinois at Urbana-Champaign
NCT05124522
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 33 |
| Phase 3 | 24 |
| Phase 4 | 17 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Multiple Sclerosis Trial Landscape
317 indexed Multiple Sclerosis studies · 120 recruiting (38%).
Phase mix: 41 late (III/IV) vs 74 early (I/II).
Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Multiple Sclerosis?
PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Multiple Sclerosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.