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NCT03759522 · ClinicalTrials.gov registry record · Phase 1
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
A Phase 1 study of Healthy and Multiple Sclerosis, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT03759522 is a Phase 1 study of Healthy and Multiple Sclerosis that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 120 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state.
The verdict
NCT03759522, a Phase 1 study of Healthy and Multiple Sclerosis, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical \[F-18\]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tracer \[F-18\]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated microglia/macrophages and provides a non-invasive measure of neuroinflammation. The primary objective of this study is to determine if pain and fatigue patients have higher levels of neuroinflammation than HC individuals as measured with \[F-18\]DPA-714-PET/MRI.
Conditions Studied
Interventions
- DRUG DPA-714 PET/MRI
Study Locations (1)
Alabama
- University of Alabama at Birmingham Medical Center - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2019-02-03 |
| Est. Completion | 2028-04 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03759522
The ClinicalTrials.gov registry entry for NCT03759522 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (81% lower). The listed sponsor is University of Alabama at Birmingham, which has 1,160 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Healthy appearing as the primary indexed condition, and to 1 intervention - of which DPA-714 PET/MRI is the first listed.
NCT03759522 reports 1 study location spanning 1 distinct geographic area - top geographies include Alabama.
Frequently Asked Questions
What is clinical trial NCT03759522 about?
NCT03759522 is a clinical study titled "Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.". The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical \[F-18\]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET t...
What is the current status of trial NCT03759522?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 120 participants. The study started on 2019-02-03. Estimated completion is 2028-04.
What conditions does trial NCT03759522 study?
This clinical trial studies the following conditions: Healthy, Multiple Sclerosis, Fibromyalgia, Chronic Fatigue Syndrome.
What interventions are being tested in trial NCT03759522?
The interventions under investigation include: DPA-714 PET/MRI (DRUG).
Who is sponsoring clinical trial NCT03759522?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03759522 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.