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NCT06641271 · ClinicalTrials.gov registry record · NA
Study to Investigate Vagus Nerve Stimulation Paired With Motor Task for Remyelination and Functional Recovery
A NA study of Multiple Sclerosis and Multiple Sclerosis (MS) - Relapsing-remitting, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- NA
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT06641271: Recruiting NA study of Multiple Sclerosis and Multiple Sclerosis (MS) - Relapsing-remitting, sponsored by University of Colorado, Denver.
NCT06641271 is a NA study of Multiple Sclerosis and Multiple Sclerosis (MS) - Relapsing-remitting that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 70 participants, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06641271, a NA study of Multiple Sclerosis and Multiple Sclerosis (MS) - Relapsing-remitting, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- NA
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn if stimulating the vagus nerve in combination with a motor task in people with multiple sclerosis can improve motor function. The main questions it aims to answer are: * Is stimulating the vagus nerve safe and feasible after demyelinating episodes? * Does a paired motor task with vagus nerve stimulation improve motor function with someone who has multiple sclerosis? Researchers will compare active vagus nerve stimulation to a sham stimulation to see if the paired vagus nerve stimulation can improve motor control. Participants will: * Come in for study visits over a six month period. Study visits are three times weekly for the first month, then single follow up visits at two, three, and six months. * During study visits, participants will complete 30 minutes of the paired vagus nerve stimulation with a motor task, specifically the grooved peg test. * At various timepoints in the study, motor and disability tests will be administered to see if there are any changes in motor control for that participants. These tests include the timed 25 foot walk test, expanded disability scale, the upper extremity portion of the Fugl-Meyer Assessment, and the Multiple Sclerosis Impact Scale - 29.
Conditions Studied
Interventions
- DEVICE Placebo
- DEVICE Closed Loop Trans-Auricular Vagus Nerve Stimulation System
Study Locations (1)
Colorado
- Clinical Translational Research Center at CU Anschutz - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2025-01-21 |
| Est. Completion | 2027-11 |
| Phase | NA |
What NCT06641271 shows while recruiting
NCT06641271 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (88% lower).
The record links to 2 conditions, with Multiple Sclerosis appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06641271 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT06641271 about?
NCT06641271 is a clinical study titled "Study to Investigate Vagus Nerve Stimulation Paired With Motor Task for Remyelination and Functional Recovery". The goal of this clinical trial is to learn if stimulating the vagus nerve in combination with a motor task in people with multiple sclerosis can improve motor function. The main questions it aims to answer are: * Is stimulating the vagus nerve safe and feasible after demyelinating episodes? * Does...
What is the current status of trial NCT06641271?
This trial is currently recruiting. It is a NA study. The enrollment target is 70 participants. The study started on 2025-01-21. Estimated completion is 2027-11.
What conditions does trial NCT06641271 study?
This clinical trial studies the following conditions: Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting.
What interventions are being tested in trial NCT06641271?
The interventions under investigation include: Placebo (DEVICE), Closed Loop Trans-Auricular Vagus Nerve Stimulation System (DEVICE).
Who is sponsoring clinical trial NCT06641271?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06641271 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Sclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06641271's enrollment target sits among peer trials
70 154th of 315 higher than 160 of 315 other Multiple Sclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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