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Metastatic Cancer: early-phase trial registry
47 of 117 indexed Metastatic Cancer trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #108 of 28,707 conditions by registered trial count.
117 US clinical trials · 47 currently recruiting · #108 of 28,707 conditions by registered trial count
Metastatic Cancer: 117 US clinical trials tracked, 47 recruiting.
Metastatic Cancer is the subject of 117 registered US clinical trials on ClinicalTrials.gov, 47 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 87 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 11 of these trials.
Enrollment posture brief
Registry condition metastatic-cancer
OPEN 47 | RECR 40% | LATE 8 | EARLY 87 | RANK #108 | SPON 11
Volume-matched condition peers
Nearest open-share peer: Knee Osteoarthritis (40% recruiting · 102 trials)
Metastatic Cancer lists 47 open slots (40% of 117 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Metastatic Cancer on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Metastatic Cancer is recruiting above its size-band peers.
47 of 117 indexed trials (40.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Metastatic Cancer trials is spread across many organizations.
Memorial Sloan Kettering Cancer Center accounts for 11 of 117 trials (9.4%). 80 distinct sponsors appear on at least one study for this condition label.
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Most Metastatic Cancer trials plan to enrol fewer than 100 people.
Median target enrolment is 54 among the 110 trials that report a genuine target (sentinel values excluded). 70 of those (63.6%) plan for fewer than 100 participants.
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Metastatic Cancer research is mostly interventional.
108 interventional and 9 observational studies make up this index (92.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
117 total, page 2 of 3
Study of Osimertinib With and Without Ramucirumab in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Xiuning Le
NCT03909334
Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)
Aadi Bioscience
NCT05103358
Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients
Verastem
NCT05375994
FS120 Phase 1/1b Study in Patients With Advanced Malignancies
invoX Pharma Limited
NCT04648202
A Study of Several Radiation Doses for Patients With Progression on Immunotherapy/Checkpoint Inhibitors
Memorial Sloan Kettering Cancer Center
NCT03693014
Biomarkers of Immune-Related Toxicity
University of Colorado, Denver
NCT03409016
Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
Memorial Sloan Kettering Cancer Center
NCT00492999
pTVG-HP DNA Vaccine With or Without pTVG-AR DNA Vaccine and Pembrolizumab in Patients With Castration-Resistant, Metastatic Prostate Cancer
University of Wisconsin, Madison
NCT04090528
A Study of AZD1390 and Stereotactic Body Radiotherapy (SBRT) for People With Metastatic Solid Tumor Cancer
Memorial Sloan Kettering Cancer Center
NCT05678010
A Study of RP-3500 in Combination With Standard Radiation Therapy in People With Solid Tumor Cancer
Memorial Sloan Kettering Cancer Center
NCT05566574
An Intervention to Help Patients and Caregivers Manage Stress and Improve Communication Skills When Talking About Cancer
Memorial Sloan Kettering Cancer Center
NCT03794635
Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer
Verastem
NCT05669482
A Study of Stereotactic Body Radiotherapy (SBRT) and Surgical Stabilization for People With Cancer That Has Spread to the Bone
Memorial Sloan Kettering Cancer Center
NCT05038124
9-ING-41 Plus Carboplatin in Salivary Gland Carcinoma
Glenn J. Hanna
NCT05010629
Metastatic Solid Cancer Clinical Trial
ImmunSYS
NCT04739618
A Phase 2 Trial for Patients With Metastatic Solid Cancer
Rampart Health, L.L.C.
NCT04713371
Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer
City of Hope Medical Center
NCT02293954
Niraparib in Tumors Metastatic to the CNS
Massachusetts General Hospital
NCT04992013
QUILT-3.064: PD-L1 t-haNK In Subjects With Locally Advanced Or Metastatic Solid Cancers
ImmunityBio
NCT04050709
Study of Cabozantinib Plus TAS102 in mCRC as Salvage Therapy
University of California, Irvine
NCT04868773
A Phase 2 Study to Evaluate the Triplet Combination of Pemetrexed Plus AB928 (Etrumadenant) + AB122 (Zimberelimab) in Patients With Previously Treated Advanced or Metastatic MTAP Deficient Urothelial Carcinoma
M.D. Anderson Cancer Center
NCT05335941
Study on Prevalence and Impact of Brain Metastases on Survival in Lung Cancer by Line of Treatment
Daiichi Sankyo
NCT06557967
Zoledronate in Treating Patients With Solid Tumors That Have Spread to the Bone
Novartis
NCT00003884
Talc in Treating Patients With Malignant Pleural Effusion
Alliance for Clinical Trials in Oncology
NCT00002622
Randomized Clinical Trial of a Multi-Modal Palliative Care Intervention
University of Colorado, Boulder
NCT04773639
Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
Alliance for Clinical Trials in Oncology
NCT00377156
A Study of Evorpacept (ALX148) in Patients With Advanced Solid Tumors and Lymphoma (ASPEN-01)
ALX Oncology
NCT03013218
Quality of Life in Patients With Liver Cancer Treated With Image-Guided Therapy
Vanderbilt University
NCT00482586
Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer
Alliance for Clinical Trials in Oncology
NCT00002716
Checkpoint Blockade Immunotherapy Combined With Stereotactic Body Radiation in Advanced Metastatic Disease
University of California, San Diego
NCT02843165
Sym021 Monotherapy, in Combination With Sym022 or Sym023, and in Combination With Both Sym022 and Sym023 in Patients With Advanced Solid Tumor Malignancies or Lymphomas
Symphogen A/S
NCT03311412
A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma
Ikena Oncology
NCT04200963
Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders
Case Comprehensive Cancer Center
NCT00255671
Heat Therapy in Treating Patients With Unresectable Primary or Metastatic Liver Cancer
M.D. Anderson Cancer Center
NCT00004136
Evaluation of Memory Skills in Patients Receiving Radiation Therapy for Brain Metastases
Radiation Therapy Oncology Group
NCT00007007
Epothilone B in Treating Patients With CNS Metastases From Breast Cancer
David Peereboom, MD
NCT00450866
Study of Pembrolizumab, Binimetinib, and Bevacizumab in Patients With Refractory Colorectal Cancer
University of Colorado, Denver
NCT03475004
Inhaled Sargramostim in Treating Patients With First Pulmonary (Lung) Recurrence of Osteosarcoma
Children's Oncology Group
NCT00066365
S0916, MLN1202 in Treating Patients With Bone Metastases
SWOG Cancer Research Network
NCT01015560
LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors
PureTech
NCT04666688
Feasibility, Acceptability and Preliminary Effects of the Spiritual Care Assessment and Intervention
Indiana University
NCT03823313
Lapatinib in Treating Patients With Advanced or Metastatic Breast Cancer That Overexpresses HER2
University of California, San Francisco
NCT00544804
Inhaled Sargramostim in Treating Patients With Melanoma Metastatic to the Lung
Alliance for Clinical Trials in Oncology
NCT00017121
Stereotactic Body Radiation Therapy and Vertebroplasty in Treating Patients With Localized Spinal Metastasis
University of Texas Southwestern Medical Center
NCT00855803
Heat Activated Liposomal Doxorubicin and Radiofrequency Ablation in Treating Patients With Primary or Metastatic Liver Tumors
National Institutes of Health Clinical Center (CC)
NCT00093444
Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer
Jonsson Comprehensive Cancer Center
NCT00024076
Busulfan in Treating Children and Adolescents With Refractory CNS Cancer
Pediatric Brain Tumor Consortium
NCT00006246
Bevacizumab in Pats w/ Recurrent ST Brain Metas Who Have Failed Whole Brain Radiation Therapy
Northwestern University
NCT01898130
Radiation Therapy in Treating Patients With Liver Metastases
Radiation Therapy Oncology Group
NCT00255814
Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment
City of Hope Medical Center
NCT00544284
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 54 |
| Phase 2 | 33 |
| Phase 3 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Metastatic Cancer records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Metastatic Cancer trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Metastatic Cancer page
117 registered trials, 47 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 47 Metastatic Cancer trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Memorial Sloan Kettering Cancer Center sponsors the most Metastatic Cancer trials on record, review their full trial history before evaluating a specific study. See Memorial Sloan Kettering Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Metastatic Cancer condition card totals 117 registered trials; most-linked intervention quality-of-life assessment; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.