Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
NCT00377156 · View on ClinicalTrials.gov ↗
Study Summary
RATIONALE: Stereotactic radiation therapy can send x-rays directly to the tumor and cause less damage to normal tissue. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether stereotactic radiation therapy is more effective with or without whole-brain radiation therapy in treating patients with brain metastases. PURPOSE: This randomized phase III trial is studying stereotactic radiation therapy and whole-brain radiation therapy to see how well they work compared with stereotactic radiation therapy alone in treating patients with brain metastases.
Conditions Studied
Interventions
- RADIATION radiation therapy
- RADIATION stereotactic radiosurgery
Study Locations (20)
California
- Memorial Medical Center — Modesto
- Kaiser Permanente - Division of Research - Oakland — Oakland
- St. Joseph Hospital Regional Cancer Center - Orange — Orange
- Rohnert Park Cancer Center — Rohnert Park
- Kaiser Permanente Medical Center - Santa Clara Kiely Campus — Santa Clara
- Kaiser Permanente Medical Center - Santa Rosa — Santa Rosa
Georgia
- Northside Hospital Cancer Center — Atlanta
- Saint Joseph's Hospital of Atlanta — Atlanta
- Northeast Georgia Medical Center — Gainesville
- Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler — Savannah
Arizona
- Arizona Oncology-Deer Valley Center — Phoenix
- Arizona Oncology Services Foundation — Scottsdale
Colorado
- University of Colorado Cancer Center at UC Health Sciences Center — Aurora
- Veterans Affairs Medical Center - Denver — Denver
Florida
- Mayo Clinic - Jacksonville — Jacksonville
- Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando
Idaho
- Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center — Boise
Illinois
- Northwest Community Hospital — Arlington Heights
Kansas
- Via Christi Cancer Center at Via Christi Regional Medical Center — Wichita
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 213 participants |
| Start Date | 2006-07 |
| Est. Completion | 2019-12-15 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00377156
The ClinicalTrials.gov registry entry for NCT00377156 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 213 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alliance for Clinical Trials in Oncology, which has 147 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions — of which radiation therapy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00377156 reports 20 study locations spanning 9 distinct geographic areas — top geographies include California, Georgia, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00377156 about?
NCT00377156 is a clinical study titled "Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases". RATIONALE: Stereotactic radiation therapy can send x-rays directly to the tumor and cause less damage to normal tissue. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether stereotactic radiation therapy is more effective with or without whole-brain radiation th...
What is the current status of trial NCT00377156?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 213 participants. The study started on 2006-07. Estimated completion is 2019-12-15.
What conditions does trial NCT00377156 study?
This clinical trial studies the following conditions: Breast Cancer, Prostate Cancer, Lung Cancer, Metastatic Cancer, Cognitive/Functional Effects. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00377156?
The interventions under investigation include: radiation therapy (RADIATION), stereotactic radiosurgery (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00377156?
This trial is sponsored by Alliance for Clinical Trials in Oncology, which has 147 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00377156 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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