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NCT05335941 · ClinicalTrials.gov registry record · Phase 2
A Phase 2 Study to Evaluate the Triplet Combination of Pemetrexed Plus AB928 (Etrumadenant) + AB122 (Zimberelimab) in Patients With Previously Treated Advanced or Metastatic MTAP Deficient Urothelial Carcinoma
A Phase 2 study of Metastatic Cancer and Urothelial Carcinoma, sponsored by M.D. Anderson Cancer Center.
- Active
- Registry status
- Phase 2
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT05335941: Active Phase 2 study of Metastatic Cancer and Urothelial Carcinoma, sponsored by M.D. Anderson Cancer Center.
NCT05335941 is a Phase 2 study of Metastatic Cancer and Urothelial Carcinoma that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 10 participants, below the 444-participant average among 109 other Metastatic Cancer trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05335941, a Phase 2 study of Metastatic Cancer and Urothelial Carcinoma, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a Phase 2 open-label, single-arm trial for patients with MTAP-deficient advanced urothelial cancer who had received prior immunotherapy. This is a single site study at the University of Texas MD Anderson Cancer Center. This study will allow patients in second line of treatment for advanced urothelial ca or beyond. All patients must have been previously treated with immune checkpoint inhibitor (ICI) therapy as per current standard of care.
Conditions Studied
Interventions
- DRUG Pemetrexed
- DRUG Zimberelimab
- DRUG Etrumadenant
Study Locations (1)
Texas
- MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2023-06-13 |
| Est. Completion | 2027-09-30 |
| Phase | Phase 2 |
What the registry record for NCT05335941 still lists
NCT05335941 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 444-participant average among 109 other Metastatic Cancer trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Metastatic Cancer appearing as the primary indexed condition, and to 3 interventions - of which Pemetrexed is the first listed.
NCT05335941 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05335941 about?
NCT05335941 is a clinical study titled "A Phase 2 Study to Evaluate the Triplet Combination of Pemetrexed Plus AB928 (Etrumadenant) + AB122 (Zimberelimab) in Patients With Previously Treated Advanced or Metastatic MTAP Deficient Urothelial Carcinoma". This is a Phase 2 open-label, single-arm trial for patients with MTAP-deficient advanced urothelial cancer who had received prior immunotherapy. This is a single site study at the University of Texas MD Anderson Cancer Center. This study will allow patients in second line of treatment for advanced u...
What is the current status of trial NCT05335941?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 10 participants. The study started on 2023-06-13. Estimated completion is 2027-09-30.
What conditions does trial NCT05335941 study?
This clinical trial studies the following conditions: Metastatic Cancer, Urothelial Carcinoma.
What interventions are being tested in trial NCT05335941?
The interventions under investigation include: Pemetrexed (DRUG), Zimberelimab (DRUG), Etrumadenant (DRUG).
Who is sponsoring clinical trial NCT05335941?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05335941 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05335941's enrollment target sits among peer trials
10 104th of 109 higher than 6 of 109 other Metastatic Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metastatic Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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