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Weight Loss clinical trials
Every US clinical trial registered for Weight Loss — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
119 US clinical trials · 31 currently recruiting
The research picture
Weight Loss has 119 registered US clinical trials, 31 of them open to new participants right now — about 26% of the total.
- 31
- recruiting participants now
- 26%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Drexel University
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
International Weight Control Registry
Tufts University
NCT04907396
Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry
Weill Medical College of Cornell University
NCT04494048
Family COMIDA (Consumo de Opciones Más Ideales De Alimentos) (Eating More Ideal Food Options)
Memorial Sloan Kettering Cancer Center
NCT07144800
VK2735 for Weight Management Type 2 Diabetes Phase 3 (VANQUISH 2)
Viking Therapeutics
NCT07104383
Optimizing an Extended Care Intervention to Promote Weight Loss Maintenance
University of Alabama at Birmingham
NCT06785064
FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)
University of North Carolina, Chapel Hill
NCT06724406
Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers
University of Illinois at Chicago
NCT05114798
Behavioral Weight Loss for Cancer Survivors in Maryland: A Trial With Adaptive Interventions
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT06463249
Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00739362
A Novel Intervention for Weight Loss in Young Adults
University of Chicago
NCT06230744
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Pichamol Jirapinyo, MD, MPH
NCT06138821
WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)
University of Florida
NCT06861790
Time Restricted Eating for WeIght LoSs MainTenance-2
NYU Langone Health
NCT07190170
Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass
Boston Scientific Corporation
NCT07015424
Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss
Boston Scientific Corporation
NCT06894498
Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder
Mayo Clinic
NCT07213466
Small Intestinal Bacterial Overgrowth (SIBO) in Pancreatic Adenocarcinoma (PDAC)
Cedars-Sinai Medical Center
NCT06988150
Dyad Plus Effectiveness/Feasibility
Wake Forest University Health Sciences
NCT04036331
Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function
University of Colorado, Boulder
NCT06776081
Weight Loss and Physical Fitness Following Pregnancy in Active Duty Women
Tripler Army Medical Center
NCT05518604
Metabolic Adaptations to Weight Loss With and Without Exercise
University of Michigan
NCT05806801
Effectiveness Study of a Lifestyle Intervention Versus Metformin in Mothers With Recent Gestational Diabetes
George Washington University
NCT06948825
Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity
John Bauer
NCT06967389
Aleniglipron Phase 2 in Type 2 Diabetes Mellitus
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
NCT07400588
Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
NCT04812314
Metabolic Health, Bones and Nuts During Weight Loss in Adults
Rutgers, The State University of New Jersey
NCT06949280
Fasted vs. Fed State Exercise
Arkansas Colleges of Health Education
NCT07487090
BrainWeighve App Feasibility Study
University of California, Los Angeles
NCT05530538
Identifying Changes in Food Behaviors Associated With Beginning GLP-1 Medication
Penn State University
NCT06843512
Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults
The University of Texas Health Science Center at San Antonio
NCT06811324
Circadian Time Restricted Eating
Oregon Health and Science University
NCT05628012
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
Signos
NCT05121844
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
Signos
NCT05874635
VK2735 for Weight Management Phase 3
Viking Therapeutics
NCT07104500
iAmHealthy Parents First: A Televideo Parent and Child Obesity Program for Rural Families
University of Kansas Medical Center
NCT05612971
Using Signos mHealth Platform in Adults for Weight Management
Signos
NCT06214221
Using Artificial Intelligence to Optimize Delivery of Weight Loss Treatment
Drexel University
NCT05231824
Choosing Healthy Activities and Lifestyle Management Through Portal Support
University of Tennessee
NCT05410353
Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program
Drexel University
NCT05408494
The Sleep2BWell Trial
Columbia University
NCT06565104
Teen Weight Control
The Miriam Hospital
NCT04861636
Anamorelin Hydrochloride, Physical Activity, and Nutritional Counseling in Decreasing Cancer-Related Fatigue in Patients With Incurable Metastatic or Recurrent Solid Tumors
M.D. Anderson Cancer Center
NCT03035409
Using Technology to Investigate Lapses in a Weight Loss Program Among Individuals With Overweight and Obesity
Williams College
NCT06023537
Effects of Mirtazapine on Appetite in Advanced Cancer Patients
M.D. Anderson Cancer Center
NCT00488072
DiAL Health Research Study
Pennington Biomedical Research Center
NCT05549362
Targeting Weight and Shape Concern Among Women with High Body Weight
The Miriam Hospital
NCT05845866
Risk of Metabolic Adaptation After Weight Loss
Medical College of Wisconsin
NCT05139420
Effectiveness of ResArgin on Adult's Body Composition and Health
Dr. Heather Hausenblaus
NCT06601049
TRE: Microbiome, Metabolic Health and Bone
Rutgers, The State University of New Jersey
NCT05548517
Low Sugar Protein Pacing, Intermittent Fasting Diet in Men and Women
Skidmore College
NCT04327141
Lorcaserin in Obesity: Identification of CNS Targets Using FMRI
Beth Israel Deaconess Medical Center
NCT02400359
Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies
Galderma R&D
NCT06351358
Healthy Eating Patterns During a Lifestyle Intervention
The University of Tennessee, Knoxville
NCT01682317
Hepatic Energy Fluxes in NASH and NAS Patients
University of Minnesota
NCT03997422
WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise
Massachusetts General Hospital
NCT06576050
Evaluation of Bariatric Endoscopic Antral Myotomy (BEAM) as a Treatment for Obesity
Brigham and Women's Hospital
NCT05713071
Weight Management Demonstration Project: HEALTH
RTI International
NCT01307280
Integrated Community-Clinical Linkage Model to Promote Weight Loss Among South Asians With Pre-Diabetes
NYU Langone Health
NCT03188094
Health Outcomes After Participating in Exercise (HOPE)
Wake Forest University Health Sciences
NCT03430115
Gestational Weight Gain and Postpartum Weight Loss in Active Duty Women (Moms Fit 2 Fight)
University of Tennessee
NCT03057808
Study of an International Commercial Program on Weight Loss and Health Outcomes
University of North Carolina, Chapel Hill
NCT03571893
Delicious Eating for Life in Southern Homes
University of North Carolina, Chapel Hill
NCT04302727
Rural Disparities in Pediatric Obesity: The iAmHealthy Intervention
University of Kansas Medical Center
NCT03304249
Effect of Exercise on Prevention of Weight Gain
University of Pittsburgh
NCT00177502
Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain
Abramson Cancer Center at Penn Medicine
NCT02906787
A Randomized Trial of Recommendations for Exercise to Prevent Weight Regain
University of Kansas
NCT01664715
VK2735 for Weight Management Phase 2 (Venture Oral Dosing)
Viking Therapeutics
NCT06828055
Project Activate: Mindfulness and Acceptance Based Behavioral Treatment for Weight Loss
Drexel University
NCT04337619
Weight Management in Rural Communities
University of Kansas
NCT02932748
Spark: Finding the Optimal Tracking Strategy for Weight Loss in a Digital Health Intervention
Stanford University
NCT05249465
A Mentor-Based Approach to Long-Term Weight Loss
University of Pittsburgh
NCT00177697
Lorcaserin: Real World Experience in an Insurance-Based Weight Management Clinic
Scripps Whittier Diabetes Institute
NCT03552107
Single Arm Trial of a Multi-component Commercial Digital Weight Loss Program
University of Connecticut
NCT04302389
Facebook and Friends: Developing an Effective Online Social Network for Weight Loss
University of Connecticut
NCT02656680
University Of Pennsylvania Weight Loss Study
University of Pennsylvania
NCT01167634
A Study to Evaluate the Effect of SlimBiotics Probiotic Formula on Weight Management and Metabolic Health Outcomes
Slimbiotics
NCT05917314
Bitter Taste and Weight Loss in Women
Rutgers University
NCT01856660
Partners at Meals - Respite Care and Home (PAM)
Medical University of South Carolina
NCT03622814
Healthy Body Healthy Souls in the Marshallese Population
University of Arkansas
NCT03377244
The Collateral Impact of Bariatric Surgery on Families
Geisinger Clinic
NCT02021630
The Role of High Intensity Interval Training in the Treatment of Adolescent Obesity
Virginia Commonwealth University
NCT03361644
Impact of Volunteer Peer-Led Intervention for Weight Control in Primary Care
Milton S. Hershey Medical Center
NCT01850550
Evaluation of Ovarian Morphology and Function in Overweight Women During Weight Loss
Cornell University
NCT01785719
Phone Coaching for Weight Loss Maintenance
The Miriam Hospital
NCT04293055
A Comparative Effectiveness Study Evaluating the Effects of Thermogenic Supplements on Body Composition
Integrative Health Technologies
NCT01423019
Effect of Soy Protein and Colorado Diet on Weight Loss and Maintenance
DuPont Nutrition and Health
NCT02380963
Healthy4Baby: Preventing Postpartum Weight Retention Among Low-Income, Black Women
Temple University
NCT01530776
Helping Employees Lose Pounds
University of Michigan
NCT02853877
The Effect of Weight Loss and Dietary Protein Intake on Bone
Rutgers University
NCT00473031
OA Clinic-Community CARE Model
University of North Carolina, Chapel Hill
NCT05349500
Effects of Lactobacillus Plantarum KABP-51 Probiotic on Body Composition, Microbiome and Mood in Healthy Overweight Adults
3 Waves Wellness
NCT06808061
Effects of Human Milk Oligosaccharide Ingestion on Weight Loss and Markers of Health
Advanced Protein Technologies Corporation
NCT06547801
Active Nutrition Program on Weight Loss
University of Memphis
NCT06249698
Esophageal Cytology With FISH in Detecting Esophageal Cancer
OHSU Knight Cancer Institute
NCT02100189
Eating Mindfully to Prevent Weight Regain
University of Utah
NCT04847843
ObeSity and Jobs in SoCioeconomically Disadvantaged CommUnities: A Randomized CLinical Precision Public HealTh Intervention --The SCULPT-Job Study
University of California, San Francis
NCT04709549
Intermittent Fasting, Caloric Restriction and Body Composition in Obese Men and Women
Skidmore College
NCT02525419
Effects of Dietary Protein on Musculoskeletal Health During Calorie Deficiency
United States Army Research Institute of Environmental Medicine
NCT01292395
Examining the Effect of Ondansetron on Bowel Prep Success
State University of New York - Downstate Medical Center
NCT05439772
Sleep Goal-focused Online Access to Lifestyle Support
University of Pittsburgh
NCT05942326
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 12 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Weight Loss Trial Landscape
ClinicalTrials.gov lists 119 US studies indexed under Weight Loss, and 31 of those are currently open to recruitment — roughly 26% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Weight Loss shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 15 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Weight Loss is led by Drexel University with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Weight Loss?
PlainTrial tracks 119 US clinical trials for Weight Loss, of which 31 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Weight Loss?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.