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ClinicalTrials.gov 31 recruiting now official registry

Weight Loss clinical trials

31 of 119 indexed Weight Loss trials are currently recruiting.

119 US clinical trials · 31 currently recruiting

Weight Loss is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 31 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Drexel University, running 4 of these trials.

The research picture

Weight Loss has 119 registered US clinical trials, 31 of them open to new participants right now, about 26% of the total.

31
recruiting participants now
26%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
4
top sponsor: Drexel University
Phase 13Phase 212Phase 32Phase 43

Active & Recent Trials

119 total, page 1 of 3

RECRUITING 100,000 participants

International Weight Control Registry

Tufts University

NCT04907396

RECRUITING open-ended (no fixed target)

Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry

Weill Medical College of Cornell University

NCT04494048

RECRUITING NA 1,319 participants

Family COMIDA (Consumo de Opciones Más Ideales De Alimentos) (Eating More Ideal Food Options)

Memorial Sloan Kettering Cancer Center

NCT07144800

RECRUITING Phase 3 1,100 participants

VK2735 for Weight Management Type 2 Diabetes Phase 3 (VANQUISH 2)

Viking Therapeutics

NCT07104383

RECRUITING NA 544 participants

Optimizing an Extended Care Intervention to Promote Weight Loss Maintenance

University of Alabama at Birmingham

NCT06785064

RECRUITING NA 256 participants

FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)

University of North Carolina, Chapel Hill

NCT06724406

RECRUITING NA 255 participants

Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers

University of Illinois at Chicago

NCT05114798

RECRUITING NA 200 participants

Behavioral Weight Loss for Cancer Survivors in Maryland: A Trial With Adaptive Interventions

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06463249

RECRUITING Phase 2 148 participants

Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00739362

RECRUITING NA 140 participants

A Novel Intervention for Weight Loss in Young Adults

University of Chicago

NCT06230744

RECRUITING NA 132 participants

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

Pichamol Jirapinyo, MD, MPH

NCT06138821

RECRUITING NA 120 participants

WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)

University of Florida

NCT06861790

RECRUITING NA 110 participants

Time Restricted Eating for WeIght LoSs MainTenance-2

NYU Langone Health

NCT07190170

RECRUITING NA 108 participants

Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass

Boston Scientific Corporation

NCT07015424

RECRUITING 100 participants

Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss

Boston Scientific Corporation

NCT06894498

RECRUITING Phase 4 100 participants

Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

Mayo Clinic

NCT07213466

RECRUITING 100 participants

Small Intestinal Bacterial Overgrowth (SIBO) in Pancreatic Adenocarcinoma (PDAC)

Cedars-Sinai Medical Center

NCT06988150

RECRUITING NA 90 participants

Dyad Plus Effectiveness/Feasibility

Wake Forest University Health Sciences

NCT04036331

RECRUITING NA 84 participants

Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function

University of Colorado, Boulder

NCT06776081

RECRUITING NA 74 participants

Weight Loss and Physical Fitness Following Pregnancy in Active Duty Women

Tripler Army Medical Center

NCT05518604

RECRUITING NA 68 participants

Metabolic Adaptations to Weight Loss With and Without Exercise

University of Michigan

NCT05806801

RECRUITING Phase 2 60 participants

Effectiveness Study of a Lifestyle Intervention Versus Metformin in Mothers With Recent Gestational Diabetes

George Washington University

NCT06948825

RECRUITING 50 participants

Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity

John Bauer

NCT06967389

RECRUITING Phase 2 50 participants

Aleniglipron Phase 2 in Type 2 Diabetes Mellitus

Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

NCT07400588

RECRUITING NA 46 participants

Exercise Effects on Adipose Tissue Structure and Function

University of Michigan

NCT04812314

RECRUITING NA 44 participants

Metabolic Health, Bones and Nuts During Weight Loss in Adults

Rutgers, The State University of New Jersey

NCT06949280

RECRUITING Phase 2 40 participants

Fasted vs. Fed State Exercise

Arkansas Colleges of Health Education

NCT07487090

RECRUITING NA 38 participants

BrainWeighve App Feasibility Study

University of California, Los Angeles

NCT05530538

RECRUITING 25 participants

Identifying Changes in Food Behaviors Associated With Beginning GLP-1 Medication

Penn State University

NCT06843512

RECRUITING Phase 2 20 participants

Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults

The University of Texas Health Science Center at San Antonio

NCT06811324

RECRUITING NA 10 participants

Circadian Time Restricted Eating

Oregon Health and Science University

NCT05628012

ACTIVE NOT RECRUITING NA 31,187 participants

Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform

Signos

NCT05121844

ACTIVE NOT RECRUITING NA 20,000 participants

Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)

Signos

NCT05874635

ACTIVE NOT RECRUITING Phase 3 4,500 participants

VK2735 for Weight Management Phase 3

Viking Therapeutics

NCT07104500

ACTIVE NOT RECRUITING NA 480 participants

iAmHealthy Parents First: A Televideo Parent and Child Obesity Program for Rural Families

University of Kansas Medical Center

NCT05612971

ACTIVE NOT RECRUITING NA 380 participants

Using Signos mHealth Platform in Adults for Weight Management

Signos

NCT06214221

ACTIVE NOT RECRUITING NA 336 participants

Using Artificial Intelligence to Optimize Delivery of Weight Loss Treatment

Drexel University

NCT05231824

ACTIVE NOT RECRUITING NA 229 participants

Choosing Healthy Activities and Lifestyle Management Through Portal Support

University of Tennessee

NCT05410353

ACTIVE NOT RECRUITING NA 228 participants

Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program

Drexel University

NCT05408494

ACTIVE NOT RECRUITING NA 210 participants

The Sleep2BWell Trial

Columbia University

NCT06565104

ACTIVE NOT RECRUITING NA 172 participants

Teen Weight Control

The Miriam Hospital

NCT04861636

ACTIVE NOT RECRUITING Phase 2 129 participants

Anamorelin Hydrochloride, Physical Activity, and Nutritional Counseling in Decreasing Cancer-Related Fatigue in Patients With Incurable Metastatic or Recurrent Solid Tumors

M.D. Anderson Cancer Center

NCT03035409

ACTIVE NOT RECRUITING NA 100 participants

Using Technology to Investigate Lapses in a Weight Loss Program Among Individuals With Overweight and Obesity

Williams College

NCT06023537

ACTIVE NOT RECRUITING Phase 2 98 participants

Effects of Mirtazapine on Appetite in Advanced Cancer Patients

M.D. Anderson Cancer Center

NCT00488072

ACTIVE NOT RECRUITING NA 90 participants

DiAL Health Research Study

Pennington Biomedical Research Center

NCT05549362

ACTIVE NOT RECRUITING NA 60 participants

Targeting Weight and Shape Concern Among Women with High Body Weight

The Miriam Hospital

NCT05845866

ACTIVE NOT RECRUITING NA 60 participants

Risk of Metabolic Adaptation After Weight Loss

Medical College of Wisconsin

NCT05139420

ACTIVE NOT RECRUITING NA 60 participants

Effectiveness of ResArgin on Adult's Body Composition and Health

Dr. Heather Hausenblaus

NCT06601049

ACTIVE NOT RECRUITING NA 48 participants

TRE: Microbiome, Metabolic Health and Bone

Rutgers, The State University of New Jersey

NCT05548517

ACTIVE NOT RECRUITING NA 40 participants

Low Sugar Protein Pacing, Intermittent Fasting Diet in Men and Women

Skidmore College

NCT04327141

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Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 12
Phase 3 2
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Weight Loss Trial Landscape

119 indexed Weight Loss studies · 31 recruiting (26%).

Phase mix: 5 late (III/IV) vs 15 early (I/II).

Top sponsor: Drexel University (4 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Weight Loss?

PlainTrial tracks 119 US clinical trials for Weight Loss, of which 31 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Weight Loss?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.