Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Weight Loss: early-phase trial registry
31 of 119 indexed Weight Loss trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #105 of 28,707 conditions by registered trial count.
119 US clinical trials · 31 currently recruiting · #105 of 28,707 conditions by registered trial count
Weight Loss: 119 US clinical trials tracked, 31 recruiting.
Weight Loss is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 31 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Drexel University, running 4 of these trials.
Enrollment posture brief
Registry condition weight-loss
OPEN 31 | RECR 26% | LATE 5 | EARLY 15 | RANK #105 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Barrett's Esophagus (26% recruiting · 23 trials)
Weight Loss lists 31 open slots (26% of 119 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Weight Loss on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Weight Loss is recruiting below its size-band peers.
31 of 119 indexed trials (26.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Weight Loss trials is spread across many organizations.
Drexel University accounts for 4 of 119 trials (3.4%). 85 distinct sponsors appear on at least one study for this condition label.
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Typical Weight Loss enrolment sits around 79 participants.
Median target enrolment is 79 among the 117 trials that report a genuine target (sentinel values excluded). 66 of those (56.4%) plan for fewer than 100 participants.
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Weight Loss research is mostly interventional.
107 interventional and 12 observational studies make up this index (89.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
119 total, page 1 of 3
International Weight Control Registry
Tufts University
NCT04907396
Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry
Weill Medical College of Cornell University
NCT04494048
Family COMIDA (Consumo de Opciones Más Ideales De Alimentos) (Eating More Ideal Food Options)
Memorial Sloan Kettering Cancer Center
NCT07144800
VK2735 for Weight Management Type 2 Diabetes Phase 3 (VANQUISH 2)
Viking Therapeutics
NCT07104383
Optimizing an Extended Care Intervention to Promote Weight Loss Maintenance
University of Alabama at Birmingham
NCT06785064
FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)
University of North Carolina, Chapel Hill
NCT06724406
Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers
University of Illinois at Chicago
NCT05114798
Behavioral Weight Loss for Cancer Survivors in Maryland: A Trial With Adaptive Interventions
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT06463249
Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00739362
A Novel Intervention for Weight Loss in Young Adults
University of Chicago
NCT06230744
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Pichamol Jirapinyo, MD, MPH
NCT06138821
WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)
University of Florida
NCT06861790
Time Restricted Eating for WeIght LoSs MainTenance-2
NYU Langone Health
NCT07190170
Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass
Boston Scientific Corporation
NCT07015424
Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss
Boston Scientific Corporation
NCT06894498
Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder
Mayo Clinic
NCT07213466
Small Intestinal Bacterial Overgrowth (SIBO) in Pancreatic Adenocarcinoma (PDAC)
Cedars-Sinai Medical Center
NCT06988150
Dyad Plus Effectiveness/Feasibility
Wake Forest University Health Sciences
NCT04036331
Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function
University of Colorado, Boulder
NCT06776081
Weight Loss and Physical Fitness Following Pregnancy in Active Duty Women
Tripler Army Medical Center
NCT05518604
Metabolic Adaptations to Weight Loss With and Without Exercise
University of Michigan
NCT05806801
Effectiveness Study of a Lifestyle Intervention Versus Metformin in Mothers With Recent Gestational Diabetes
George Washington University
NCT06948825
Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity
John Bauer
NCT06967389
Aleniglipron Phase 2 in Type 2 Diabetes Mellitus
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
NCT07400588
Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
NCT04812314
Metabolic Health, Bones and Nuts During Weight Loss in Adults
Rutgers, The State University of New Jersey
NCT06949280
Fasted vs. Fed State Exercise
Arkansas Colleges of Health Education
NCT07487090
BrainWeighve App Feasibility Study
University of California, Los Angeles
NCT05530538
Identifying Changes in Food Behaviors Associated With Beginning GLP-1 Medication
Penn State University
NCT06843512
Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults
The University of Texas Health Science Center at San Antonio
NCT06811324
Circadian Time Restricted Eating
Oregon Health and Science University
NCT05628012
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
Signos
NCT05121844
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
Signos
NCT05874635
VK2735 for Weight Management Phase 3
Viking Therapeutics
NCT07104500
iAmHealthy Parents First: A Televideo Parent and Child Obesity Program for Rural Families
University of Kansas Medical Center
NCT05612971
Using Signos mHealth Platform in Adults for Weight Management
Signos
NCT06214221
Using Artificial Intelligence to Optimize Delivery of Weight Loss Treatment
Drexel University
NCT05231824
Choosing Healthy Activities and Lifestyle Management Through Portal Support
University of Tennessee
NCT05410353
Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program
Drexel University
NCT05408494
The Sleep2BWell Trial
Columbia University
NCT06565104
Teen Weight Control
The Miriam Hospital
NCT04861636
Anamorelin Hydrochloride, Physical Activity, and Nutritional Counseling in Decreasing Cancer-Related Fatigue in Patients With Incurable Metastatic or Recurrent Solid Tumors
M.D. Anderson Cancer Center
NCT03035409
Using Technology to Investigate Lapses in a Weight Loss Program Among Individuals With Overweight and Obesity
Williams College
NCT06023537
Effects of Mirtazapine on Appetite in Advanced Cancer Patients
M.D. Anderson Cancer Center
NCT00488072
DiAL Health Research Study
Pennington Biomedical Research Center
NCT05549362
Targeting Weight and Shape Concern Among Women with High Body Weight
The Miriam Hospital
NCT05845866
Risk of Metabolic Adaptation After Weight Loss
Medical College of Wisconsin
NCT05139420
Effectiveness of ResArgin on Adult's Body Composition and Health
Dr. Heather Hausenblaus
NCT06601049
TRE: Microbiome, Metabolic Health and Bone
Rutgers, The State University of New Jersey
NCT05548517
Low Sugar Protein Pacing, Intermittent Fasting Diet in Men and Women
Skidmore College
NCT04327141
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 12 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Weight Loss records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Weight Loss trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Weight Loss page
119 registered trials, 31 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 31 Weight Loss trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Drexel University sponsors the most Weight Loss trials on record, review their full trial history before evaluating a specific study. See Drexel University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Weight Loss condition card totals 119 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.