Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Liver Cancer

Open-data reference.

81 US clinical trials · 30 currently recruiting

Active & Recent Trials

RECRUITING 9,150 participants

Biobank for Cholestatic Liver Diseases.

Mayo Clinic

NCT03445585

RECRUITING Phase 4 5,500 participants

National Liver Cancer Screening Trial

University of Texas Southwestern Medical Center

NCT06084234

RECRUITING 1,750 participants

Collection of Blood From Patients With Cancer

National Cancer Institute (NCI)

NCT00034216

RECRUITING 1,200 participants

Multi-analyte Blood Test Clinical Trial

Helio Genomics

NCT05199259

RECRUITING 750 participants

Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies

National Cancer Institute (NCI)

NCT00451022

RECRUITING NA 644 participants

Diversity and Inclusion in Research Underpinning Prevention and Therapy Trials

Icahn School of Medicine at Mount Sinai

NCT05146297

RECRUITING 600 participants

Identification of New Serum Diagnostic Markers of Hepatocellular Carcinoma

Stanford University

NCT00373347

RECRUITING 500 participants

National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer

National Cancer Institute (NCI)

NCT04145141

RECRUITING 400 participants

Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection

University of Colorado, Denver

NCT05517811

RECRUITING NA 360 participants

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Cedars-Sinai Medical Center

NCT04907643

RECRUITING NA 200 participants

EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

Case Comprehensive Cancer Center

NCT06263088

RECRUITING NA 100 participants

Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis

Case Comprehensive Cancer Center

NCT07044362

RECRUITING 100 participants

DESTINY-PANTUMOUR04

AstraZeneca

NCT07124000

RECRUITING 100 participants

4D-MRI for Precision Medicine

University of Virginia

NCT04657042

RECRUITING NA 86 participants

Jump: MR Simulation For Radiation Therapy Master Protocol

Brigham and Women's Hospital

NCT04545957

RECRUITING Phase 1 80 participants

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Angiex

NCT06440005

RECRUITING NA 78 participants

Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients

Duke University

NCT04933435

RECRUITING Phase 2 62 participants

REGULUS: MRI-guided Adaptive SABR for Liver Cancers

Stanford University

NCT07223307

RECRUITING Phase 2 51 participants

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

University of California, Irvine

NCT06580002

RECRUITING NA 50 participants

Feasibility Study of CBCT for IGRT in Cancer Patients

Varian, a Siemens Healthineers Company

NCT06681233

RECRUITING 40 participants

Development and Testing of a Patient-facing Educational Tool About Liver Cancer Prevention

M.D. Anderson Cancer Center

NCT07010315

RECRUITING NA 40 participants

HepQuant: Study to Assess the Role of Blood-based Biomarkers and Quantitative MR Imaging for Patients Receiving Radiation Therapy for Liver Cancer

Montefiore Medical Center

NCT06899152

RECRUITING Phase 2 30 participants

Y-90 Treatment Response Using Transarterial Radioembolization

Thomas Jefferson University

NCT07145801

RECRUITING Phase 2 24 participants

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

University of California, Irvine

NCT07447050

RECRUITING Phase 1 24 participants

Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

Baylor College of Medicine

NCT04715191

RECRUITING NA 18 participants

vGRID SBRT: A Phase I Clinical Trial in Unresectable or Metastatic HCC

University of Kansas Medical Center

NCT05727787

RECRUITING Phase 1 18 participants

Intra-tumoral (IT) Injection of vvDD-hIL2-2-RG-1 for Metastatic Gastrointestinal and Peritoneal Tumors

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

NCT07001592

RECRUITING Phase 2 18 participants

Checkpoint Inhibition In Pediatric Hepatocellular Carcinoma

Allison O'Neill, MD

NCT04134559

RECRUITING Phase 1 15 participants

ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma

Eureka Therapeutics

NCT04634357

RECRUITING 10 participants

Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women

Washington University School of Medicine

NCT06904365

ACTIVE NOT RECRUITING 6,000 participants

Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract

Memorial Sloan Kettering Cancer Center

NCT00582647

ACTIVE NOT RECRUITING 2,990 participants

ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk

Exact Sciences Corporation

NCT05064553

ACTIVE NOT RECRUITING Phase 3 545 participants

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

Bristol-Myers Squibb

NCT03383458

ACTIVE NOT RECRUITING Phase 3 231 participants

Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection

Memorial Sloan Kettering Cancer Center

NCT02523443

ACTIVE NOT RECRUITING NA 150 participants

Examinations of Tissue From Ablated Malignant Liver Metastases as Predictors of Outcome

Memorial Sloan Kettering Cancer Center

NCT01494324

ACTIVE NOT RECRUITING NA 120 participants

Radioembolization Trial Utilizing Eye90 Microspheres™ for the Treatment of Hepatocellular Carcinoma (HCC)

ABK Biomedical

NCT05953337

ACTIVE NOT RECRUITING Phase 2 58 participants

Domvanalimab and Zimberelimab in Advanced Liver Cancers

University of Texas Southwestern Medical Center

NCT05724563

ACTIVE NOT RECRUITING NA 32 participants

Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning: Phase 2

Milton S. Hershey Medical Center

NCT06384417

ACTIVE NOT RECRUITING Early Phase 1 20 participants

A Study to Test the Safety and Feasibility of Nivolumab With Drug Eluting Bead Transarterial Chemoembolization in Patients With Liver Cancer

Memorial Sloan Kettering Cancer Center

NCT03143270

ACTIVE NOT RECRUITING NA 20 participants

Pressure-enabled Delivery in Radioembolization (TriNav Study)

Massachusetts General Hospital

NCT05128032

ACTIVE NOT RECRUITING NA 19 participants

TriNav Infusion System for the Evaluation of Fidelity Between 99mTc-MAA and Y90-Microspheres Hepatic Distribution for Dosimetry Treatment Planning

M.D. Anderson Cancer Center

NCT05743842

ACTIVE NOT RECRUITING Phase 1 16 participants

QUILT-2.025 NANT Neoepitope Yeast Vaccine (YE-NEO-001): Adjuvant Immunotherapy Using a Personalized Neoepitope Yeast-Based Vaccine To Induce T-Cell Responses In Subjects W/ Previously Treated Cancers.

NantBioScience

NCT03552718

ACTIVE NOT RECRUITING Phase 1 14 participants

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

Baylor College of Medicine

NCT04377932

ACTIVE NOT RECRUITING Phase 1 10 participants

Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Patients With Pediatric Solid Tumors (GAP)

Baylor College of Medicine

NCT02932956

COMPLETED 500 participants

Radiolabeled Glass Beads in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery

Northwestern University

NCT00530010

COMPLETED Phase 3 405 participants

Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers

Alliance for Clinical Trials in Oncology

NCT02349412

COMPLETED 228 participants

A Retrospective Review of Malignant Liver Tumors

University of Oklahoma

NCT00728650

COMPLETED 180 participants

Human Liver Explants for HIF-1 Alpha Analysis/Comparison (HIF HCC)

Northwestern University

NCT00866957

COMPLETED Phase 2 172 participants

CS1008- in Combination With Sorafenib Compared to Sorafenib Alone in Subjects With Advanced Liver Cancer

Daiichi Sankyo

NCT01033240

COMPLETED 137 participants

Quality of Life in Patients With Liver Cancer Treated With Image-Guided Therapy

Vanderbilt University

NCT00482586

COMPLETED Phase 1 128 participants

Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B-6527 in Participants With Advanced Hepatocellular Carcinoma

H3 Biomedicine

NCT02834780

COMPLETED NA 117 participants

A Pilot Study of Perihepatic Phlebotomy During Hepatic Resections

Memorial Sloan Kettering Cancer Center

NCT01749332

COMPLETED Phase 1 100 participants

Trial of Bi-shRNA-furin and GMCSF Augmented Autologous Tumor Cell Vaccine for Advanced Cancer

Gradalis

NCT01061840

COMPLETED Phase 2 94 participants

A Study of Individualized Stereotactic Body Radiation Therapy (SBRT) for Intrahepatic Cancer

University of Michigan Rogel Cancer Center

NCT01522937

COMPLETED 75 participants

Evaluation of Image-Guided Liver Surgical System for Resection of Liver Cancer

Pathfinder Therapeutics

NCT00782886

COMPLETED Phase 2 59 participants

Heat Therapy in Treating Patients With Unresectable Primary or Metastatic Liver Cancer

M.D. Anderson Cancer Center

NCT00004136

COMPLETED 46 participants

Breath Analysis Based Disease Biomarkers

Mayo Clinic

NCT04341012

COMPLETED Phase 2 45 participants

Erlotinib Plus Bevacizumab in Hepatocellular Carcinoma (HCC) as Second-line Therapy

M.D. Anderson Cancer Center

NCT01180959

COMPLETED 36 participants

Measurement of Pro-angiogenic Markers in Patients With Hepatic Metastases Undergoing SIRT

Rutgers, The State University of New Jersey

NCT00994370

COMPLETED Phase 1 30 participants

Pharmacokinetics of Doxorubicin in cTACE of Liver Cancer

Yale University

NCT02753881

COMPLETED Phase 1 30 participants

Heat Activated Liposomal Doxorubicin and Radiofrequency Ablation in Treating Patients With Primary or Metastatic Liver Tumors

National Institutes of Health Clinical Center (CC)

NCT00093444

COMPLETED NA 29 participants

Stereotactic Body Radiation Therapy (SBRT) in Metastatic Non-small Cell Lung Cancer

Wake Forest University Health Sciences

NCT01185639

COMPLETED Phase 1 28 participants

Gemcitabine Hydrochloride, Oxaliplatin, and Erlotinib Hydrochloride in Treating Patients With Advanced Biliary Tract Cancer, Pancreatic Cancer, Duodenal Cancer, or Ampullary Cancer

Vanderbilt-Ingram Cancer Center

NCT00987766

COMPLETED 27 participants

Evaluation of a Minimally Invasive Image-Guided Surgery System for Hepatic Ablation Procedures

Pathfinder Therapeutics

NCT01238666

COMPLETED Phase 2 26 participants

Bevacizumab and Chemoembolization in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery

Yale University

NCT00335829

COMPLETED Phase 2 24 participants

Doxorubicin and Interleukin-2 in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery

Roswell Park Cancer Institute

NCT00004248

COMPLETED Phase 1 23 participants

Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Treatment-Refractory Solid Tumor Malignancies

Novita Pharmaceuticals

NCT03199586

COMPLETED Phase 2 23 participants

A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT01356628

COMPLETED Phase 2 22 participants

Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT00024258

COMPLETED Phase 1 22 participants

IL-2 Expressing, Attenuated Salmonella Typhimurium in Unresectable Hepatic Spread

Masonic Cancer Center, University of Minnesota

NCT01099631

COMPLETED Phase 2 22 participants

Floxuridine and Dexamethasone as a Hepatic Arterial Infusion and Bevacizumab in Treating Patients With Primary Liver Cancer That Cannot be Removed by Surgery

Memorial Sloan Kettering Cancer Center

NCT00410956

COMPLETED Phase 2 20 participants

Sorafenib Tosylate Before and After Hepatic Arterial Chemoembolization With Doxorubicin Hydrochloride and Mitomycin C in Treating Patients With Localized Liver Cancer That Cannot Be Removed by Surgery

Rutgers, The State University of New Jersey

NCT00949182

COMPLETED Phase 2 16 participants

Dolastatin 10 in Treating Patients With Metastatic Or Recurrent Liver, Bile Duct, or Gallbladder Cancer

University of Chicago

NCT00003557

COMPLETED NA 15 participants

A Pilot Study to Assess Theragnostically Planned Liver Radiation to Optimize Radiation Therapy

Indiana University

NCT03338062

COMPLETED NA 13 participants

Study of New Software Used During Ablations

National Institutes of Health Clinical Center (CC)

NCT01906021

COMPLETED Phase 2 11 participants

Cisplatin or Carboplatin and Sorafenib in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery

University of Miami

NCT00875615

COMPLETED Phase 1 6 participants

Vaccine Therapy in Treating Patients With Liver Cancer

Jonsson Comprehensive Cancer Center

NCT00005629

COMPLETED Phase 2 4 participants

Photodynamic Therapy in Treating Patients With Cancer of the Bile Duct, Gallbladder, or Pancreas

Memorial Sloan Kettering Cancer Center

NCT00003923

COMPLETED Phase 2 3 participants

Integrated Imaging Strategy to Phenotype Progression of Liver Tumors During and After Chemoembolization

National Institutes of Health Clinical Center (CC)

NCT02471313

COMPLETED Phase 2

DX-8951f in Treating Patients With Biliary Cancer

Daiichi Sankyo

NCT00005938

COMPLETED Phase 2

DX-8951f in Treating Patients With Liver Cancer

Daiichi Sankyo

NCT00004108

Phase Distribution

PhaseTrial count
Early Phase 1 16
Phase 2 22
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Liver Cancer Trial Landscape

ClinicalTrials.gov lists 81 US studies indexed under Liver Cancer, and 30 of those are currently open to recruitment — roughly 37% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Liver Cancer shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 38 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Liver Cancer is led by Memorial Sloan Kettering Cancer Center with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 81 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Liver Cancer?

PlainTrial tracks 81 US clinical trials for Liver Cancer, of which 30 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Liver Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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