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ClinicalTrials.gov 30 recruiting now official registry

Liver Cancer clinical trials

30 of 81 indexed Liver Cancer trials are currently recruiting.

81 US clinical trials · 30 currently recruiting

Liver Cancer is the subject of 81 registered US clinical trials on ClinicalTrials.gov, 30 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 38 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 8 of these trials.

The research picture

Liver Cancer has 81 registered US clinical trials, 30 of them open to new participants right now, about 37% of the total.

30
recruiting participants now
37%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
8
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 116Phase 222Phase 33Phase 41

Active & Recent Trials

81 total, page 2 of 2

COMPLETED Phase 1 128 participants

Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B-6527 in Participants With Advanced Hepatocellular Carcinoma

H3 Biomedicine

NCT02834780

COMPLETED NA 117 participants

A Pilot Study of Perihepatic Phlebotomy During Hepatic Resections

Memorial Sloan Kettering Cancer Center

NCT01749332

COMPLETED Phase 1 100 participants

Trial of Bi-shRNA-furin and GMCSF Augmented Autologous Tumor Cell Vaccine for Advanced Cancer

Gradalis

NCT01061840

COMPLETED Phase 2 94 participants

A Study of Individualized Stereotactic Body Radiation Therapy (SBRT) for Intrahepatic Cancer

University of Michigan Rogel Cancer Center

NCT01522937

COMPLETED 75 participants

Evaluation of Image-Guided Liver Surgical System for Resection of Liver Cancer

Pathfinder Therapeutics

NCT00782886

COMPLETED Phase 2 59 participants

Heat Therapy in Treating Patients With Unresectable Primary or Metastatic Liver Cancer

M.D. Anderson Cancer Center

NCT00004136

COMPLETED 46 participants

Breath Analysis Based Disease Biomarkers

Mayo Clinic

NCT04341012

COMPLETED Phase 2 45 participants

Erlotinib Plus Bevacizumab in Hepatocellular Carcinoma (HCC) as Second-line Therapy

M.D. Anderson Cancer Center

NCT01180959

COMPLETED 36 participants

Measurement of Pro-angiogenic Markers in Patients With Hepatic Metastases Undergoing SIRT

Rutgers, The State University of New Jersey

NCT00994370

COMPLETED Phase 1 30 participants

Pharmacokinetics of Doxorubicin in cTACE of Liver Cancer

Yale University

NCT02753881

COMPLETED Phase 1 30 participants

Heat Activated Liposomal Doxorubicin and Radiofrequency Ablation in Treating Patients With Primary or Metastatic Liver Tumors

National Institutes of Health Clinical Center (CC)

NCT00093444

COMPLETED NA 29 participants

Stereotactic Body Radiation Therapy (SBRT) in Metastatic Non-small Cell Lung Cancer

Wake Forest University Health Sciences

NCT01185639

COMPLETED Phase 1 28 participants

Gemcitabine Hydrochloride, Oxaliplatin, and Erlotinib Hydrochloride in Treating Patients With Advanced Biliary Tract Cancer, Pancreatic Cancer, Duodenal Cancer, or Ampullary Cancer

Vanderbilt-Ingram Cancer Center

NCT00987766

COMPLETED 27 participants

Evaluation of a Minimally Invasive Image-Guided Surgery System for Hepatic Ablation Procedures

Pathfinder Therapeutics

NCT01238666

COMPLETED Phase 2 26 participants

Bevacizumab and Chemoembolization in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery

Yale University

NCT00335829

COMPLETED Phase 2 24 participants

Doxorubicin and Interleukin-2 in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery

Roswell Park Cancer Institute

NCT00004248

COMPLETED Phase 1 23 participants

Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Treatment-Refractory Solid Tumor Malignancies

Novita Pharmaceuticals

NCT03199586

COMPLETED Phase 2 23 participants

A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT01356628

COMPLETED Phase 2 22 participants

Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT00024258

COMPLETED Phase 1 22 participants

IL-2 Expressing, Attenuated Salmonella Typhimurium in Unresectable Hepatic Spread

Masonic Cancer Center, University of Minnesota

NCT01099631

COMPLETED Phase 2 22 participants

Floxuridine and Dexamethasone as a Hepatic Arterial Infusion and Bevacizumab in Treating Patients With Primary Liver Cancer That Cannot be Removed by Surgery

Memorial Sloan Kettering Cancer Center

NCT00410956

COMPLETED Phase 2 20 participants

Sorafenib Tosylate Before and After Hepatic Arterial Chemoembolization With Doxorubicin Hydrochloride and Mitomycin C in Treating Patients With Localized Liver Cancer That Cannot Be Removed by Surgery

Rutgers, The State University of New Jersey

NCT00949182

COMPLETED Phase 2 16 participants

Dolastatin 10 in Treating Patients With Metastatic Or Recurrent Liver, Bile Duct, or Gallbladder Cancer

University of Chicago

NCT00003557

COMPLETED NA 15 participants

A Pilot Study to Assess Theragnostically Planned Liver Radiation to Optimize Radiation Therapy

Indiana University

NCT03338062

COMPLETED NA 13 participants

Study of New Software Used During Ablations

National Institutes of Health Clinical Center (CC)

NCT01906021

COMPLETED Phase 2 11 participants

Cisplatin or Carboplatin and Sorafenib in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery

University of Miami

NCT00875615

COMPLETED Phase 1 6 participants

Vaccine Therapy in Treating Patients With Liver Cancer

Jonsson Comprehensive Cancer Center

NCT00005629

COMPLETED Phase 2 4 participants

Photodynamic Therapy in Treating Patients With Cancer of the Bile Duct, Gallbladder, or Pancreas

Memorial Sloan Kettering Cancer Center

NCT00003923

COMPLETED Phase 2 3 participants

Integrated Imaging Strategy to Phenotype Progression of Liver Tumors During and After Chemoembolization

National Institutes of Health Clinical Center (CC)

NCT02471313

COMPLETED Phase 2

DX-8951f in Treating Patients With Biliary Cancer

Daiichi Sankyo

NCT00005938

COMPLETED Phase 2

DX-8951f in Treating Patients With Liver Cancer

Daiichi Sankyo

NCT00004108

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Phase Distribution

PhaseTrial count
Phase 1 16
Phase 2 22
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Liver Cancer Trial Landscape

81 indexed Liver Cancer studies · 30 recruiting (37%).

Phase mix: 4 late (III/IV) vs 38 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (8 trials), 9 others listed. 31 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Liver Cancer?

PlainTrial tracks 81 US clinical trials for Liver Cancer, of which 30 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Liver Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.