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2026 data Public-data reference. official source

Small Lymphocytic Lymphoma

Open-data reference.

82 US clinical trials · 36 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 1,200 participants

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Merck Sharp & Dohme

NCT06136559

RECRUITING 1,000 participants

Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

National Heart, Lung, and Blood Institute (NHLBI)

NCT00923507

RECRUITING Phase 3 700 participants

A Long-term Extension Study of PCI-32765 (Ibrutinib)

Janssen Research & Development

NCT01804686

RECRUITING Phase 3 662 participants

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Loxo Oncology

NCT05254743

RECRUITING Phase 3 630 participants

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

BeOne Medicines

NCT06943872

RECRUITING Phase 1 614 participants

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

BeOne Medicines

NCT05006716

RECRUITING Phase 3 500 participants

A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

BeOne Medicines

NCT06973187

RECRUITING Phase 2 320 participants

A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic Lymphocytic Leukemia

Janssen Research & Development

NCT05963074

RECRUITING Phase 1 276 participants

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

AstraZeneca

NCT06564038

RECRUITING Phase 2 249 participants

A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Loxo Oncology

NCT06588478

RECRUITING Phase 3 247 participants

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

National Cancer Institute (NCI)

NCT04269902

RECRUITING NA 200 participants

Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

Masonic Cancer Center, University of Minnesota

NCT01962636

RECRUITING Phase 1 135 participants

Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

Imugene Limited

NCT03666000

RECRUITING Phase 1 132 participants

Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Leukemias

National Cancer Institute (NCI)

NCT06364423

RECRUITING Phase 2 120 participants

Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Mayo Clinic

NCT03516617

RECRUITING Phase 1 120 participants

AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

Carna Biosciences

NCT05602363

RECRUITING Phase 2 100 participants

A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

VA Office of Research and Development

NCT06520098

RECRUITING Phase 2 80 participants

Anti-pneumococcal Vaccine Strategy in Patients With Chronic Lymphocytic Leukemia

Seema Bhat

NCT05417165

RECRUITING Phase 2 62 participants

Intermittent Versus Continuous Venetoclax With Acalabrutinib for CLL/SLL

Zulfa Omer

NCT07014917

RECRUITING Phase 2 60 participants

Pneumococcal Pneumonia Vaccine Series (PCV20 and PPSV23) in Patients With Chronic Lymphocytic Leukemia Associated Immunodeficiency, PROTECT CLL Trial

University of Utah

NCT05183854

RECRUITING Phase 2 60 participants

Fixed Duration Pirtobrutinib and Obinutuzumab in Chronic Lymphocytic Leukemia

Inhye Ahn

NCT06333262

RECRUITING Phase 2 60 participants

Acalabrutinib and Obinutuzumab for the Treatment of Chronic Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT04505254

RECRUITING Phase 2 52 participants

Acalabrutinib in Combination With Venetoclax or Obinutuzumab for the Treatment of Treatment-naive Chronic Lymphocytic Leukemia

Ohio State University Comprehensive Cancer Center

NCT05336812

RECRUITING 45 participants

Vaccine Responses in Patient With Multiple Myeloma and Non-Hodgkin Lymphoma After CAR-T Treatment

OHSU Knight Cancer Institute

NCT06784167

RECRUITING Early Phase 1 42 participants

64Cu-LLP2A for Imaging Hematologic Malignancies

Washington University School of Medicine

NCT06636175

RECRUITING NA 40 participants

Combating Cancer-Related Fatigue: A Personalized Supportive Care Program

UNC Lineberger Comprehensive Cancer Center

NCT06860880

RECRUITING Phase 2 40 participants

Venetoclax-Obinutuzumab +/- Acalabrutinib in R/R CLL

Massachusetts General Hospital

NCT04560322

RECRUITING Phase 1 40 participants

Mosunetuzumab for CLL MRD Clearance

Inhye Ahn

NCT07052695

RECRUITING Phase 1 36 participants

Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma

C. Babis Andreadis

NCT04545762

RECRUITING Phase 2 34 participants

LP-168 and Obinutuzumab for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Variants of This

Zulfa Omer

NCT06978088

RECRUITING Phase 2 33 participants

Venetoclax and Obinutuzumab Followed by Epcoritamab for the Treatment of Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma, LonGEVity Trial

City of Hope Medical Center

NCT07218510

RECRUITING Phase 1 32 participants

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

Vironexis Biotherapeutics

NCT06533579

RECRUITING Phase 2 30 participants

Pirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients With CLL or SLL Resistant to Covalent BTKi

Kerry Rogers

NCT06466122

RECRUITING Phase 2 27 participants

Acalabrutinib, Venetoclax and Durvalumab for the Treatment of Richter Transformation From Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Mayo Clinic

NCT05388006

RECRUITING Phase 2 22 participants

Study of Epcoritamab as a Consolidation Therapy in CLL/SLL

Zulfa Omer

NCT07108998

RECRUITING Phase 2 20 participants

Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell Lymphoma

Fred Hutchinson Cancer Center

NCT06839053

ACTIVE NOT RECRUITING Phase 3 720 participants

Assessing the Ability of Combination Treatment With Venetoclax to Permit Time Limited Therapy in Chronic Lymphocytic Leukemia

National Cancer Institute (NCI)

NCT03701282

ACTIVE NOT RECRUITING Phase 3 600 participants

A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

Loxo Oncology

NCT04965493

ACTIVE NOT RECRUITING Phase 3 590 participants

A Study Comparing Zanubrutinib With Bendamustine Plus Rituximab in Participants With Previously Untreated CLL or SLL

BeiGene

NCT03336333

ACTIVE NOT RECRUITING Phase 3 529 participants

Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

National Cancer Institute (NCI)

NCT02048813

ACTIVE NOT RECRUITING Phase 3 465 participants

Testing the Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

National Cancer Institute (NCI)

NCT03737981

ACTIVE NOT RECRUITING Phase 3 309 participants

A Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Loxo Oncology

NCT05023980

ACTIVE NOT RECRUITING Phase 1 306 participants

ACP-196 (Acalabrutinib), a Novel Bruton Tyrosine Kinase (BTK) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia

Acerta Pharma

NCT02029443

ACTIVE NOT RECRUITING Phase 3 300 participants

A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)

Merck Sharp & Dohme

NCT05624554

ACTIVE NOT RECRUITING Phase 3 238 participants

Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Loxo Oncology

NCT04666038

ACTIVE NOT RECRUITING Phase 2 234 participants

Venetoclax and Ibrutinib in Treating Patients With Chronic or Small Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT02756897

ACTIVE NOT RECRUITING Phase 1 217 participants

Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, r/r ALL and 1L HR LBCL

Novartis Pharmaceuticals

NCT03960840

ACTIVE NOT RECRUITING Phase 1 195 participants

Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome

Genmab

NCT04623541

ACTIVE NOT RECRUITING Phase 1 190 participants

A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)

NCT03162536

ACTIVE NOT RECRUITING Phase 1 150 participants

NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers

Nkarta

NCT05020678

ACTIVE NOT RECRUITING Phase 2 120 participants

Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom

Cellectar Biosciences

NCT02952508

ACTIVE NOT RECRUITING Phase 2 81 participants

Ibrutinib, Fludarabine Phosphate, Cyclophosphamide, and Obinutuzumab in Treating Patients With Chronic Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT02629809

ACTIVE NOT RECRUITING Phase 2 72 participants

Pirtobrutinib and Venetoclax With MRD Detection for Previously Untreated Chronic Lymphocytic Leukemia

Mayo Clinic

NCT05677919

ACTIVE NOT RECRUITING Phase 2 55 participants

A Study on Limiting Treatment Time With Acalabrutinib Combined With Obinutuzumab in People With CLL or SLL

Memorial Sloan Kettering Cancer Center

NCT04722172

ACTIVE NOT RECRUITING Phase 2 50 participants

Atezolizumab, Obinutuzumab, and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Relapsed or Refractory Richter Syndrome

M.D. Anderson Cancer Center

NCT02846623

ACTIVE NOT RECRUITING Phase 2 49 participants

Lenalidomide and Vaccine Therapy in Treating Patients With Early-Stage Asymptomatic Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

National Cancer Institute (NCI)

NCT01351896

ACTIVE NOT RECRUITING Phase 2 42 participants

Ibrutinib as an Immune Modulating Agent for Patients With Asymptomatic, High-risk CLL/SLL Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Jennifer Woyach

NCT02518555

ACTIVE NOT RECRUITING Phase 1 40 participants

Safe Accelerated Venetoclax Escalation in CLL

Dana-Farber Cancer Institute

NCT04843904

ACTIVE NOT RECRUITING Phase 2 33 participants

Ixazomib Citrate and Rituximab in Treating Patients With Indolent B-cell Non-Hodgkin Lymphoma

University of Washington

NCT02339922

ACTIVE NOT RECRUITING Phase 2 29 participants

A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL

National Heart, Lung, and Blood Institute (NHLBI)

NCT02514083

ACTIVE NOT RECRUITING Phase 2 29 participants

Acalabrutinib, Umbralisib, and Ublituximab (AU2) In Relapsed and Untreated CLL

Jennifer R. Brown, MD, PhD

NCT04624633

ACTIVE NOT RECRUITING Phase 2 26 participants

Tafasitamab and Zanubrutinib for the Treatment of Patients With Newly Diagnosed Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, TaZA CLL Study

City of Hope Medical Center

NCT05718869

ACTIVE NOT RECRUITING Phase 1 24 participants

Venetoclax With High-dose Ibrutinib for CLL Progressing on Single Agent Ibrutinib

Michael Choi

NCT03422393

ACTIVE NOT RECRUITING Phase 1 4 participants

A Study Assessing Adverse Event and How Oral ABBV-453 Moves Through the Body in Adult Participants With Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

AbbVie

NCT06291220

COMPLETED Phase 3 652 participants

A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia

BeiGene

NCT03734016

COMPLETED Phase 3 391 participants

A Phase 3 Study of Ibrutinib (PCI-32765) Versus Ofatumumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia

Pharmacyclics

NCT01578707

COMPLETED Phase 2 279 participants

Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)

National Heart, Lung, and Blood Institute (NHLBI)

NCT02208037

COMPLETED Phase 2 125 participants

Efficacy and Safety Study of Idelalisib in Participants With Indolent B-Cell Non-Hodgkin Lymphomas

Gilead Sciences

NCT01282424

COMPLETED Phase 2 77 participants

Ofatumumab for Patients With Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

SCRI Development Innovations

NCT01113632

COMPLETED Phase 1 50 participants

Oral Clofarabine for Relapsed/Refractory Non-Hodgkin Lymphoma

Massachusetts General Hospital

NCT00644189

COMPLETED Phase 2 50 participants

Phase II Safety and Efficacy Study of Single-agent AT-101 in Patients With Relapsed or Refractory B-cell Malignancies

Ascenta Therapeutics

NCT00275431

COMPLETED Phase 1 49 participants

A Phase 1b Study Evaluating the Safety and Tolerability of ABT-199 in Combination With Rituximab in Subjects With Relapsed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

AbbVie

NCT01682616

COMPLETED Phase 2 41 participants

Arsenic Trioxide in Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

SCRI Development Innovations

NCT00193518

COMPLETED Phase 1 36 participants

Etanercept and Rituximab in Patients With Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

John Byrd

NCT00201682

COMPLETED Phase 2 34 participants

Study of Bendamustine/Rituxan Induction Chemotherapy With Revlimid Maintenance for Relapsed/Refractory CLL and SLL

University of Wisconsin, Madison

NCT00974233

COMPLETED Phase 2 24 participants

Study to Evaluate Safety and Preliminary Efficacy of Tafasitamab With Idelalisib or Venetoclax in R/R CLL/SLL Patients Pretreated With BTKi

MorphoSys

NCT02639910

COMPLETED Phase 2 22 participants

Imexon for Relapsed Follicular and Aggressive Lymphomas

University of Rochester

NCT01314014

COMPLETED Phase 1 16 participants

Phase 1 Study of TG02 Citrate in Patients With Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

Tragara Pharmaceuticals

NCT01699152

COMPLETED Phase 2 16 participants

Perifosine in Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Daphne Friedman

NCT00873457

COMPLETED Phase 1 16 participants

Pharmacodynamic (PD) Study of Intranodal Adenovirus-CD154 (Ad-ISF35) in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

University of California, San Diego

NCT00850057

COMPLETED Phase 1 11 participants

Dendritic Cell Therapy, Cryosurgery, and Pembrolizumab in Treating Patients With Non-Hodgkin Lymphoma

Mayo Clinic

NCT03035331

COMPLETED Phase 1 7 participants

Duvelisib and Nivolumab in Treating Patients With Richter Syndrome or Transformed Follicular Lymphoma

David Bond, MD

NCT03892044

Phase Distribution

PhaseTrial count
Early Phase 1 24
Phase 2 38
Phase 3 16

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Small Lymphocytic Lymphoma Trial Landscape

ClinicalTrials.gov lists 82 US studies indexed under Small Lymphocytic Lymphoma, and 36 of those are currently open to recruitment — roughly 44% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Small Lymphocytic Lymphoma shows 16 late-stage studies (Phase 3 and Phase 4 combined) alongside 62 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Small Lymphocytic Lymphoma is led by National Cancer Institute (NCI) with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 82 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Small Lymphocytic Lymphoma?

PlainTrial tracks 82 US clinical trials for Small Lymphocytic Lymphoma, of which 36 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Small Lymphocytic Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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