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2026 data Public-data reference. official source

Peripheral Arterial Disease

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80 US clinical trials · 35 currently recruiting

Active & Recent Trials

RECRUITING 300,000 participants

A Real-World Registry of Chronic Wounds and Ulcers

U.S. Wound Registry

NCT02280733
RECRUITING 14,000 participants

Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes

Baylor Research Institute

NCT01904851
RECRUITING Phase 3 6,150 participants

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

Population Health Research Institute

NCT04774159
RECRUITING Phase 3 1,205 participants

Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease

Eli Lilly and Company

NCT07223593
RECRUITING 1,000 participants

Advanta VXT and Flixene PMCF Registry

Atrium Medical Corporation

NCT07161583
RECRUITING 500 participants

Pounce™ Thrombectomy System Retrospective Registry

SurModics

NCT05868161
RECRUITING 450 participants

The Percutaneous Transmural Arterial Bypass -1 Study (Post Approval Registry)

Endologix

NCT06315023
RECRUITING NA 400 participants

Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease

Mayo Clinic

NCT06952543
RECRUITING NA 376 participants

SELUTION4BTK Trial

M.A. Med Alliance S.A.

NCT05055297
RECRUITING NA 350 participants

Intravascular Ultrasound Imaging Guidance for Optimal Revascularization of Limb Arteries

Baylor Research Institute

NCT07353905
RECRUITING Phase 4 350 participants

Vascular Trial Associated Registry Pilot

Corewell Health West

NCT07076082
RECRUITING NA 300 participants

Prehabilitation and Rehabilitation in PAD

Palo Alto Veterans Institute for Research

NCT06566976
RECRUITING NA 244 participants

The GORE VBX FORWARD Clinical Study: A Comparison of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis to Bare Metal Stenting for Patients With Complex Iliac Occlusive Disease

W.L.Gore & Associates

NCT05811364
RECRUITING Phase 3 210 participants

SMART Exercise for PAD

Northwestern University

NCT06032065
RECRUITING NA 159 participants

The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)

Avantec Vascular

NCT06321575
RECRUITING 150 participants

Using SnapshotNIR With Provocative Leg Maneuver for PAD Assessment

Kent Imaging

NCT06237621
RECRUITING Phase 1 144 participants

Effects of Carnosine In Patients With Peripheral Arterial Disease Patients

Shahid Baba

NCT06480760
RECRUITING NA 120 participants

Randomized Clinical Trial for Ewing Amputation in the VA

VA Office of Research and Development

NCT05437562
RECRUITING NA 100 participants

PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

LimFlow

NCT05313165
RECRUITING Phase 4 70 participants

Ramipril Treatment of Claudication: Oxidative Damage and Muscle Fibrosis

University of Nebraska

NCT02842424
RECRUITING 70 participants

Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status

University of Virginia

NCT06009276
RECRUITING Phase 2 64 participants

Passive Stretching in Peripheral Arterial Disease Patients

University of Wisconsin, La Crosse

NCT06420752
RECRUITING NA 60 participants

MitoQ Treatment of Claudication: Myofiber and Micro-vessel Pathology

University of Nebraska

NCT06409949
RECRUITING NA 60 participants

Assessment of the Utility of the Pantheris Small Vessel (SV) System

Avinger

NCT04793581
RECRUITING 50 participants

CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions

Yale University

NCT05145478
RECRUITING NA 50 participants

The ROAMM-EHR Study

University of Florida

NCT06263322
RECRUITING NA 40 participants

Fuzzy Wale Compression Stockinet to Promote Healing Following Transtibial Amputation for Peripheral Arterial Disease

Mayo Clinic

NCT06308562
RECRUITING Phase 2 34 participants

Fisetin to Reduce Senescence and Mobility Impairment in PAD

Northwestern University

NCT06399809
RECRUITING NA 30 participants

Augmentation of Limb Perfusion With Contrast Ultrasound

Oregon Health and Science University

NCT03195556
RECRUITING 25 participants

Use of Thermal Imaging Camera to Assess Perfusion Before and After Vascular Intervention

University Hospitals Cleveland Medical Center

NCT06544135
RECRUITING NA 24 participants

Leg Exercise Assistive Paddling (LEAP) Therapy for Peripheral Artery Disease

University of Nebraska

NCT06389149
RECRUITING Early Phase 1 20 participants

Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease

University of Nebraska

NCT06319339
RECRUITING Phase 1 20 participants

Carnosine for Peripheral Arterial Disease Patients

Shahid Baba

NCT05371145
RECRUITING NA 15 participants

SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease

University of Nebraska

NCT06480786
RECRUITING NA 10 participants

Replexa+ Shortwave Diathermy Device for Patients Diagnosed With Peripheral Artery Disease and Peripheral Neuropathy

Indiana University

NCT07336381
ACTIVE NOT RECRUITING 458 participants

SCOPE-CLI: Shifting Care and Outcomes for Patients With Endangered Limbs

Yale University

NCT04710563
ACTIVE NOT RECRUITING NA 300 participants

SELUTION4SFA Trial

M.A. Med Alliance S.A.

NCT05132361
ACTIVE NOT RECRUITING NA 188 participants

TORUS 2 IDE Clinical Study

Endologix

NCT04130737
ACTIVE NOT RECRUITING NA 177 participants

A Clinical Evaluation of the MicroSTent® PeripherAl Vascular SteNt in Subjects With Arterial Disease Below the Knee (STAND)

Micro Medical Solution

NCT03477604
ACTIVE NOT RECRUITING Phase 4 75 participants

The Impact of Factor Xa Inhibition on Thrombosis, Platelet Activation, and Endothelial Function in Peripheral Artery Disease

Vanderbilt University Medical Center

NCT05009862
ACTIVE NOT RECRUITING Phase 1 40 participants

BGC101 (EnEPC) Autologous Cell Therapy From Patient's Own Blood for Treatment of Critical Limb Ischemia (CLI)

BioGenCell

NCT02805023
COMPLETED 595 participants

BRAVO: Biomarker Risk Assessment in Vulnerable Outpatients

Northwestern University

NCT02276781
COMPLETED NA 300 participants

Pivotal Trial of a Novel Paclitaxel-Coated Percutaneous Angioplasty Balloon

Spectranetics Corporation

NCT01858428
COMPLETED 271 participants

Effectiveness of Medical Therapy, Endovascular Therapy, and Surgery for Peripheral Arterial Disease

Kaiser Permanente

NCT01588067
COMPLETED NA 267 participants

Evaluation of the GORE TIGRIS Vascular Stent

W.L.Gore & Associates

NCT01576055
COMPLETED NA 230 participants

The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD

University of West Florida

NCT04089943
COMPLETED NA 220 participants

Mechanisms That Produce the Leg Dysfunction of Claudication & Treatment Strategies

University of Nebraska

NCT01970332
COMPLETED 215 participants

The Impact of Diabetes on REvascularization

Vanderbilt University Medical Center

NCT03085524
COMPLETED NA 210 participants

Treadmill Exercise and GM-CSF Study to Improving Functioning in Peripheral Artery Disease (PAD)

Northwestern University

NCT01408901
COMPLETED Phase 2 203 participants

Edoxaban in Peripheral Arterial Disease

Daiichi Sankyo

NCT01802775
COMPLETED NA 174 participants

Motivational Interviewing (MI) for African Americans With Peripheral Arterial Disease (PAD)

University of Kansas Medical Center

NCT01321086
COMPLETED 161 participants

Validation of a Novel Oscillometric-Based Algorithm for Determination of the Ankle-Brachial Index

Summit Doppler Systems

NCT01165437
COMPLETED NA 130 participants

A Prospective Single-Arm Multicenter StuDy of the BarE TEmporary SPur StEnt System foR the tREatment of Vascular Lesions Located in the infrapoplitEal Arteries beLow the Knee (DEEPER REVEAL)

ReFlow Medical

NCT05358353
COMPLETED NA 116 participants

Implementation of Telemedicine for Patient With Lower Extremity Wounds

University of California, Davis

NCT04440839
COMPLETED NA 112 participants

The OPC for Optimal Delivery of Paclitaxel for the Prevention of Endovascular Restenosis - Above and Below the Knee

Horizons International Peripheral Group

NCT02464501
COMPLETED NA 108 participants

EverFlex Post Approval Study

Medtronic Endovascular

NCT01680835
COMPLETED NA 108 participants

A Prospective, Multicenter Atherectomy Study Showing Luminal Gain in Subjects With Peripheral Vascular Blockages

Ra Medical Systems

NCT04241224
COMPLETED 100 participants

Distributed Registry

Stanford University

NCT03898570
COMPLETED Phase 2 86 participants

Use of Ixmyelocel-T (Formerly Vascular Repair Cells [VRC]) in Patients With Peripheral Arterial Disease to Treat Critical Limb Ischemia

Vericel Corporation

NCT00468000
COMPLETED 82 participants

TurboPower + DCB Treatment of Femoropopliteal De Novo/ Restenotic and In-Stent Restenosis Lesions

Spectranetics Corporation

NCT03306199
COMPLETED Phase 1 81 participants

A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation

Indiana University

NCT02685098
COMPLETED 70 participants

Pilot Study to Determine the Optimal Technique for Measurement of Ankle Blood Pressures

Summit Doppler Systems

NCT00819598
COMPLETED Phase 4 55 participants

The Jetstream G3™ Calcium Study

Boston Scientific Corporation

NCT01273623
COMPLETED 40 participants

VasoStat vs. TR Band for Radial Hemostasis

Forge Medical

NCT04163471
COMPLETED Phase 2 32 participants

Nitrites, Exercise, and Peripheral Arterial Disease

Duke University

NCT01684930
COMPLETED NA 27 participants

Local Paclitaxel Delivery for SFA Disease

University of Oklahoma

NCT00821028
COMPLETED NA 24 participants

Ischemic Preconditioning Claudication Study

Medical College of Wisconsin

NCT03511157
COMPLETED NA 22 participants

Dexamethasone Infusion to the Adventitia to Enhance Clinical Efficacy After Femoropopliteal Revascularization

University of California, San Francis

NCT01507558
COMPLETED NA 22 participants

Cardiac Rehabilitation Program in Peripheral Arterial Disease

University of Kansas Medical Center

NCT03251391
COMPLETED Phase 1 20 participants

ALD-301 for Critical Limb Ischemia, Randomized Trial

Aldagen

NCT00392509
COMPLETED NA 19 participants

Endothelial Function in Lower Extremity Bypass Grafts

Brigham and Women's Hospital

NCT00759707
COMPLETED NA 18 participants

Exercise and Weight Loss in PAD

VA Office of Research and Development

NCT02607033
COMPLETED Phase 1 15 participants

Study of Human Placenta-derived Cells (PDA002) to Evaluate the Safety and Effectiveness in Subjects With PAD and DFU

Celularity Incorporated

NCT01859117
COMPLETED NA 15 participants

Drug Eluting Stent for the Management of PERipheral Arterial Disease Of the SFA (DESPERADO-SFA Study)

Arkansas Heart Hospital

NCT02734836
COMPLETED NA 12 participants

Feasibility Study to Evaluate Therapeutic Ultrasound (TUS) to Acutely Increase the Perfusion in Peripheral Arterial Disease (PAD)

Vibrato Medical

NCT05888740
COMPLETED NA 11 participants

Dietary Nitrate Supplementation and Thermoregulation

University of Nebraska

NCT03506646
COMPLETED Early Phase 1 10 participants

Safety and Preliminary Efficacy of Adipose Derived Stem Cells and Low Frequency Ultrasound in PAD

Arkansas Heart Hospital

NCT02756884
COMPLETED Phase 1 9 participants

Natural Vascular Scaffold (NVS) Therapy for Treatment of Atherosclerotic Lesions (Activate I)

Alucent Biomedical

NCT04188262
COMPLETED NA 8 participants

The Use of Fish Oil to Reduce Inflammation Caused by a Peripheral Vascular Intervention

University of California, San Francis

NCT02096757
COMPLETED NA 5 participants

BOLD MRI as a Surrogate of Improved Muscle Oxygenation Following Endovascular Therapy for the Treatment of CLI

Zimmer Biomet

NCT02601430

Phase Distribution

PhaseTrial count
Early Phase 1 9
Phase 2 5
Phase 3 3
Phase 4 4

Top Sponsors

University of Nebraska 7 trials
Northwestern University 4 trials
Summit Doppler Systems 2 trials
Spectranetics Corporation 2 trials
Arkansas Heart Hospital 2 trials
Shahid Baba 2 trials
Endologix 2 trials
Baylor Research Institute 2 trials
M.A. Med Alliance S.A. 2 trials
W.L.Gore & Associates 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Peripheral Arterial Disease Trial Landscape

ClinicalTrials.gov lists 80 US studies indexed under Peripheral Arterial Disease, and 35 of those are currently open to recruitment — roughly 44% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Peripheral Arterial Disease shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 14 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Peripheral Arterial Disease is led by University of Nebraska with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 80 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Peripheral Arterial Disease?

PlainTrial tracks 80 US clinical trials for Peripheral Arterial Disease, of which 35 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Peripheral Arterial Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

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Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Read our methodology — how this data is sourced, computed, and verified.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →