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ClinicalTrials.gov 35 recruiting now official registry

Peripheral Arterial Disease clinical trials

35 of 80 indexed Peripheral Arterial Disease trials are currently recruiting.

80 US clinical trials · 35 currently recruiting

Peripheral Arterial Disease is the subject of 80 registered US clinical trials on ClinicalTrials.gov, 35 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is University of Nebraska, running 7 of these trials.

The research picture

Peripheral Arterial Disease has 80 registered US clinical trials, 35 of them open to new participants right now, about 44% of the total.

35
recruiting participants now
44%
of trials open to enrollment
7
in Phase 3–4 (later-stage)
7
top sponsor: University of Nebraska
Phase 19Phase 25Phase 33Phase 44

Active & Recent Trials

80 total, page 1 of 2

RECRUITING 300,000 participants

A Real-World Registry of Chronic Wounds and Ulcers

U.S. Wound Registry

NCT02280733

RECRUITING 14,000 participants

Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes

Baylor Research Institute

NCT01904851

RECRUITING Phase 3 6,150 participants

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

Population Health Research Institute

NCT04774159

RECRUITING Phase 3 1,205 participants

Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease

Eli Lilly and Company

NCT07223593

RECRUITING 1,000 participants

Advanta VXT and Flixene PMCF Registry

Atrium Medical Corporation

NCT07161583

RECRUITING 500 participants

Pounce™ Thrombectomy System Retrospective Registry

SurModics

NCT05868161

RECRUITING 450 participants

The Percutaneous Transmural Arterial Bypass -1 Study (Post Approval Registry)

Endologix

NCT06315023

RECRUITING NA 400 participants

Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease

Mayo Clinic

NCT06952543

RECRUITING NA 376 participants

SELUTION4BTK Trial

M.A. Med Alliance S.A.

NCT05055297

RECRUITING NA 350 participants

Intravascular Ultrasound Imaging Guidance for Optimal Revascularization of Limb Arteries

Baylor Research Institute

NCT07353905

RECRUITING Phase 4 350 participants

Vascular Trial Associated Registry Pilot

Corewell Health West

NCT07076082

RECRUITING NA 300 participants

Prehabilitation and Rehabilitation in PAD

Palo Alto Veterans Institute for Research

NCT06566976

RECRUITING NA 244 participants

The GORE VBX FORWARD Clinical Study: A Comparison of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis to Bare Metal Stenting for Patients With Complex Iliac Occlusive Disease

W.L.Gore & Associates

NCT05811364

RECRUITING Phase 3 210 participants

SMART Exercise for PAD

Northwestern University

NCT06032065

RECRUITING NA 159 participants

The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)

Avantec Vascular

NCT06321575

RECRUITING 150 participants

Using SnapshotNIR With Provocative Leg Maneuver for PAD Assessment

Kent Imaging

NCT06237621

RECRUITING Phase 1 144 participants

Effects of Carnosine In Patients With Peripheral Arterial Disease Patients

Shahid Baba

NCT06480760

RECRUITING NA 120 participants

Randomized Clinical Trial for Ewing Amputation in the VA

VA Office of Research and Development

NCT05437562

RECRUITING NA 100 participants

PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

LimFlow

NCT05313165

RECRUITING Phase 4 70 participants

Ramipril Treatment of Claudication: Oxidative Damage and Muscle Fibrosis

University of Nebraska

NCT02842424

RECRUITING 70 participants

Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status

University of Virginia

NCT06009276

RECRUITING Phase 2 64 participants

Passive Stretching in Peripheral Arterial Disease Patients

University of Wisconsin, La Crosse

NCT06420752

RECRUITING NA 60 participants

MitoQ Treatment of Claudication: Myofiber and Micro-vessel Pathology

University of Nebraska

NCT06409949

RECRUITING NA 60 participants

Assessment of the Utility of the Pantheris Small Vessel (SV) System

Avinger

NCT04793581

RECRUITING 50 participants

CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions

Yale University

NCT05145478

RECRUITING NA 50 participants

The ROAMM-EHR Study

University of Florida

NCT06263322

RECRUITING NA 40 participants

Fuzzy Wale Compression Stockinet to Promote Healing Following Transtibial Amputation for Peripheral Arterial Disease

Mayo Clinic

NCT06308562

RECRUITING Phase 2 34 participants

Fisetin to Reduce Senescence and Mobility Impairment in PAD

Northwestern University

NCT06399809

RECRUITING NA 30 participants

Augmentation of Limb Perfusion With Contrast Ultrasound

Oregon Health and Science University

NCT03195556

RECRUITING 25 participants

Use of Thermal Imaging Camera to Assess Perfusion Before and After Vascular Intervention

University Hospitals Cleveland Medical Center

NCT06544135

RECRUITING NA 24 participants

Leg Exercise Assistive Paddling (LEAP) Therapy for Peripheral Artery Disease

University of Nebraska

NCT06389149

RECRUITING Early Phase 1 20 participants

Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease

University of Nebraska

NCT06319339

RECRUITING Phase 1 20 participants

Carnosine for Peripheral Arterial Disease Patients

Shahid Baba

NCT05371145

RECRUITING NA 15 participants

SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease

University of Nebraska

NCT06480786

RECRUITING NA 10 participants

Replexa+ Shortwave Diathermy Device for Patients Diagnosed With Peripheral Artery Disease and Peripheral Neuropathy

Indiana University

NCT07336381

ACTIVE NOT RECRUITING 458 participants

SCOPE-CLI: Shifting Care and Outcomes for Patients With Endangered Limbs

Yale University

NCT04710563

ACTIVE NOT RECRUITING NA 300 participants

SELUTION4SFA Trial

M.A. Med Alliance S.A.

NCT05132361

ACTIVE NOT RECRUITING NA 188 participants

TORUS 2 IDE Clinical Study

Endologix

NCT04130737

ACTIVE NOT RECRUITING NA 177 participants

A Clinical Evaluation of the MicroSTent® PeripherAl Vascular SteNt in Subjects With Arterial Disease Below the Knee (STAND)

Micro Medical Solution

NCT03477604

ACTIVE NOT RECRUITING Phase 4 75 participants

The Impact of Factor Xa Inhibition on Thrombosis, Platelet Activation, and Endothelial Function in Peripheral Artery Disease

Vanderbilt University Medical Center

NCT05009862

ACTIVE NOT RECRUITING Phase 1 40 participants

BGC101 (EnEPC) Autologous Cell Therapy From Patient's Own Blood for Treatment of Critical Limb Ischemia (CLI)

BioGenCell

NCT02805023

COMPLETED 595 participants

BRAVO: Biomarker Risk Assessment in Vulnerable Outpatients

Northwestern University

NCT02276781

COMPLETED NA 300 participants

Pivotal Trial of a Novel Paclitaxel-Coated Percutaneous Angioplasty Balloon

Spectranetics Corporation

NCT01858428

COMPLETED 271 participants

Effectiveness of Medical Therapy, Endovascular Therapy, and Surgery for Peripheral Arterial Disease

Kaiser Permanente

NCT01588067

COMPLETED NA 267 participants

Evaluation of the GORE TIGRIS Vascular Stent

W.L.Gore & Associates

NCT01576055

COMPLETED NA 230 participants

The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD

University of West Florida

NCT04089943

COMPLETED NA 220 participants

Mechanisms That Produce the Leg Dysfunction of Claudication & Treatment Strategies

University of Nebraska

NCT01970332

COMPLETED 215 participants

The Impact of Diabetes on REvascularization

Vanderbilt University Medical Center

NCT03085524

COMPLETED NA 210 participants

Treadmill Exercise and GM-CSF Study to Improving Functioning in Peripheral Artery Disease (PAD)

Northwestern University

NCT01408901

COMPLETED Phase 2 203 participants

Edoxaban in Peripheral Arterial Disease

Daiichi Sankyo

NCT01802775

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Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 5
Phase 3 3
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Peripheral Arterial Disease Trial Landscape

80 indexed Peripheral Arterial Disease studies · 35 recruiting (44%).

Phase mix: 7 late (III/IV) vs 14 early (I/II).

Top sponsor: University of Nebraska (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Peripheral Arterial Disease?

PlainTrial tracks 80 US clinical trials for Peripheral Arterial Disease, of which 35 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Peripheral Arterial Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.