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Peripheral Arterial Disease clinical trials
35 of 80 indexed Peripheral Arterial Disease trials are currently recruiting.
80 US clinical trials · 35 currently recruiting
Peripheral Arterial Disease is the subject of 80 registered US clinical trials on ClinicalTrials.gov, 35 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is University of Nebraska, running 7 of these trials.
The research picture
Peripheral Arterial Disease has 80 registered US clinical trials, 35 of them open to new participants right now, about 44% of the total.
- 35
- recruiting participants now
- 44%
- of trials open to enrollment
- 7
- in Phase 3–4 (later-stage)
- 7
- top sponsor: University of Nebraska
Active & Recent Trials
80 total, page 1 of 2
A Real-World Registry of Chronic Wounds and Ulcers
U.S. Wound Registry
NCT02280733
Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes
Baylor Research Institute
NCT01904851
Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk
Population Health Research Institute
NCT04774159
Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease
Eli Lilly and Company
NCT07223593
Advanta VXT and Flixene PMCF Registry
Atrium Medical Corporation
NCT07161583
Pounce™ Thrombectomy System Retrospective Registry
SurModics
NCT05868161
The Percutaneous Transmural Arterial Bypass -1 Study (Post Approval Registry)
Endologix
NCT06315023
Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease
Mayo Clinic
NCT06952543
SELUTION4BTK Trial
M.A. Med Alliance S.A.
NCT05055297
Intravascular Ultrasound Imaging Guidance for Optimal Revascularization of Limb Arteries
Baylor Research Institute
NCT07353905
Vascular Trial Associated Registry Pilot
Corewell Health West
NCT07076082
Prehabilitation and Rehabilitation in PAD
Palo Alto Veterans Institute for Research
NCT06566976
The GORE VBX FORWARD Clinical Study: A Comparison of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis to Bare Metal Stenting for Patients With Complex Iliac Occlusive Disease
W.L.Gore & Associates
NCT05811364
SMART Exercise for PAD
Northwestern University
NCT06032065
The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)
Avantec Vascular
NCT06321575
Using SnapshotNIR With Provocative Leg Maneuver for PAD Assessment
Kent Imaging
NCT06237621
Effects of Carnosine In Patients With Peripheral Arterial Disease Patients
Shahid Baba
NCT06480760
Randomized Clinical Trial for Ewing Amputation in the VA
VA Office of Research and Development
NCT05437562
PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
LimFlow
NCT05313165
Ramipril Treatment of Claudication: Oxidative Damage and Muscle Fibrosis
University of Nebraska
NCT02842424
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
University of Virginia
NCT06009276
Passive Stretching in Peripheral Arterial Disease Patients
University of Wisconsin, La Crosse
NCT06420752
MitoQ Treatment of Claudication: Myofiber and Micro-vessel Pathology
University of Nebraska
NCT06409949
Assessment of the Utility of the Pantheris Small Vessel (SV) System
Avinger
NCT04793581
CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions
Yale University
NCT05145478
The ROAMM-EHR Study
University of Florida
NCT06263322
Fuzzy Wale Compression Stockinet to Promote Healing Following Transtibial Amputation for Peripheral Arterial Disease
Mayo Clinic
NCT06308562
Fisetin to Reduce Senescence and Mobility Impairment in PAD
Northwestern University
NCT06399809
Augmentation of Limb Perfusion With Contrast Ultrasound
Oregon Health and Science University
NCT03195556
Use of Thermal Imaging Camera to Assess Perfusion Before and After Vascular Intervention
University Hospitals Cleveland Medical Center
NCT06544135
Leg Exercise Assistive Paddling (LEAP) Therapy for Peripheral Artery Disease
University of Nebraska
NCT06389149
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
University of Nebraska
NCT06319339
Carnosine for Peripheral Arterial Disease Patients
Shahid Baba
NCT05371145
SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
University of Nebraska
NCT06480786
Replexa+ Shortwave Diathermy Device for Patients Diagnosed With Peripheral Artery Disease and Peripheral Neuropathy
Indiana University
NCT07336381
SCOPE-CLI: Shifting Care and Outcomes for Patients With Endangered Limbs
Yale University
NCT04710563
SELUTION4SFA Trial
M.A. Med Alliance S.A.
NCT05132361
TORUS 2 IDE Clinical Study
Endologix
NCT04130737
A Clinical Evaluation of the MicroSTent® PeripherAl Vascular SteNt in Subjects With Arterial Disease Below the Knee (STAND)
Micro Medical Solution
NCT03477604
The Impact of Factor Xa Inhibition on Thrombosis, Platelet Activation, and Endothelial Function in Peripheral Artery Disease
Vanderbilt University Medical Center
NCT05009862
BGC101 (EnEPC) Autologous Cell Therapy From Patient's Own Blood for Treatment of Critical Limb Ischemia (CLI)
BioGenCell
NCT02805023
BRAVO: Biomarker Risk Assessment in Vulnerable Outpatients
Northwestern University
NCT02276781
Pivotal Trial of a Novel Paclitaxel-Coated Percutaneous Angioplasty Balloon
Spectranetics Corporation
NCT01858428
Effectiveness of Medical Therapy, Endovascular Therapy, and Surgery for Peripheral Arterial Disease
Kaiser Permanente
NCT01588067
Evaluation of the GORE TIGRIS Vascular Stent
W.L.Gore & Associates
NCT01576055
The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD
University of West Florida
NCT04089943
Mechanisms That Produce the Leg Dysfunction of Claudication & Treatment Strategies
University of Nebraska
NCT01970332
The Impact of Diabetes on REvascularization
Vanderbilt University Medical Center
NCT03085524
Treadmill Exercise and GM-CSF Study to Improving Functioning in Peripheral Artery Disease (PAD)
Northwestern University
NCT01408901
Edoxaban in Peripheral Arterial Disease
Daiichi Sankyo
NCT01802775
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 5 |
| Phase 3 | 3 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Peripheral Arterial Disease Trial Landscape
80 indexed Peripheral Arterial Disease studies · 35 recruiting (44%).
Phase mix: 7 late (III/IV) vs 14 early (I/II).
Top sponsor: University of Nebraska (7 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Peripheral Arterial Disease?
PlainTrial tracks 80 US clinical trials for Peripheral Arterial Disease, of which 35 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Peripheral Arterial Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.