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2026 data Public-data reference. official source

Small-cell Lung Cancer

Open-data reference.

26 US clinical trials · 19 currently recruiting

Active & Recent Trials

RECRUITING 1,650 participants

A Multicenter Cancer Biospecimen Collection Study

Cofactor Genomics

NCT04510129

RECRUITING Phase 3 480 participants

A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)

Zai Lab (Shanghai) Co.

NCT07218146

RECRUITING Phase 3 330 participants

A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

Amgen

NCT07005128

RECRUITING Phase 2 280 participants

Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer

Fox Chase Cancer Center

NCT05800587

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING NA 244 participants

Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy

Wake Forest University Health Sciences

NCT05703269

RECRUITING Phase 1 208 participants

A Study of IDE849 in Patients With DLL3 Expressing Tumors Including Small Cell Lung Cancer

IDEAYA Biosciences

NCT07174583

RECRUITING NA 100 participants

LOcally ABLatIve ThErapy for OligopRogressive Lung And Thoracic MalignanciEs (OBLITERATE)

University of California, Davis

NCT06103682

RECRUITING NA 70 participants

A Study of Hospital-at-Home for People Receiving Tarlatamab

Memorial Sloan Kettering Cancer Center

NCT06957314

RECRUITING Phase 1 67 participants

A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

Novelty Nobility

NCT06805825

RECRUITING Phase 2 62 participants

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Memorial Sloan Kettering Cancer Center

NCT05419076

RECRUITING Phase 2 49 participants

Durvalumab and Ablative Radiation in Small Cell Lung Cancer (DARES)

University of Chicago

NCT05068232

RECRUITING Phase 1 42 participants

Small Cell Lung Cancer Irinotecan and CDC2-like Kinase Inhibition Trial (SLICK Trial)

Washington University School of Medicine

NCT07155200

RECRUITING Phase 2 38 participants

Phase 2 Study of Fingolimod in Lung Cancers

Medical University of South Carolina

NCT06424067

RECRUITING Phase 2 37 participants

Study of PLK1 Inhibitor, Onvansertib, in Relapsed Small Cell Lung Cancer

University of Maryland, Baltimore

NCT05450965

RECRUITING 30 participants

Small Cell Lung Cancer Community Engagement to Eliminate Research Discepancies

Addario Lung Cancer Medical Institute

NCT06486428

RECRUITING NA 30 participants

Prospective Study of Intensity-Modulated Proton Therapy (IMPT) for Small Cell Lung Cancer

Emory University

NCT04342429

RECRUITING Phase 2 30 participants

Study of Trilaciclib and Lurbinectidin

UNC Lineberger Comprehensive Cancer Center

NCT05578326

RECRUITING 20 participants

7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)

University of Missouri-Columbia

NCT07175077

ACTIVE NOT RECRUITING Phase 2 110 participants

Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

BioNTech SE

NCT06449209

ACTIVE NOT RECRUITING Phase 1 70 participants

TH1902 in Patients With Advanced Solid Tumors

Theratechnologies

NCT04706962

ACTIVE NOT RECRUITING Phase 1 31 participants

ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung Cancers

Washington University School of Medicine

NCT05616624

ACTIVE NOT RECRUITING Phase 1 25 participants

Radiotherapy and Durvalumab/Durvalumab Combo (Tremelimumab/Olaparid) for Small Cell Lung Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT03923270

ACTIVE NOT RECRUITING Phase 2 14 participants

Targeted Therapy With CDK4/6 Inhibitors in Chemo-Refractory, Rb Wild-Type Extensive SCLC

Case Comprehensive Cancer Center

NCT04010357

COMPLETED Phase 1 105 participants

A Study of SY 5609, a Selective CDK7 Inhibitor, in Advanced Solid Tumors

Syros Pharmaceuticals

NCT04247126

COMPLETED NA 20 participants

Hippocampal Prophylactic Cranial Irradiation for Small Cell Lung Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT01797159

Phase Distribution

PhaseTrial count
Early Phase 1 8
Phase 2 8
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Small-cell Lung Cancer Trial Landscape

ClinicalTrials.gov lists 26 US studies indexed under Small-cell Lung Cancer, and 19 of those are currently open to recruitment — roughly 73% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Small-cell Lung Cancer shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 16 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Small-cell Lung Cancer is led by Washington University School of Medicine with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 26 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Small-cell Lung Cancer?

PlainTrial tracks 26 US clinical trials for Small-cell Lung Cancer, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Small-cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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