Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Small-cell Lung Cancer
Open-data reference.
26 US clinical trials · 19 currently recruiting
Active & Recent Trials
A Multicenter Cancer Biospecimen Collection Study
Cofactor Genomics
NCT04510129
A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)
Zai Lab (Shanghai) Co.
NCT07218146
A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)
Amgen
NCT07005128
Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer
Fox Chase Cancer Center
NCT05800587
A Study of MGC026 in Participants With Advanced Solid Tumors
MacroGenics
NCT06242470
Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy
Wake Forest University Health Sciences
NCT05703269
A Study of IDE849 in Patients With DLL3 Expressing Tumors Including Small Cell Lung Cancer
IDEAYA Biosciences
NCT07174583
LOcally ABLatIve ThErapy for OligopRogressive Lung And Thoracic MalignanciEs (OBLITERATE)
University of California, Davis
NCT06103682
A Study of Hospital-at-Home for People Receiving Tarlatamab
Memorial Sloan Kettering Cancer Center
NCT06957314
A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit
Novelty Nobility
NCT06805825
A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain
Memorial Sloan Kettering Cancer Center
NCT05419076
Durvalumab and Ablative Radiation in Small Cell Lung Cancer (DARES)
University of Chicago
NCT05068232
Small Cell Lung Cancer Irinotecan and CDC2-like Kinase Inhibition Trial (SLICK Trial)
Washington University School of Medicine
NCT07155200
Phase 2 Study of Fingolimod in Lung Cancers
Medical University of South Carolina
NCT06424067
Study of PLK1 Inhibitor, Onvansertib, in Relapsed Small Cell Lung Cancer
University of Maryland, Baltimore
NCT05450965
Small Cell Lung Cancer Community Engagement to Eliminate Research Discepancies
Addario Lung Cancer Medical Institute
NCT06486428
Prospective Study of Intensity-Modulated Proton Therapy (IMPT) for Small Cell Lung Cancer
Emory University
NCT04342429
Study of Trilaciclib and Lurbinectidin
UNC Lineberger Comprehensive Cancer Center
NCT05578326
7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)
University of Missouri-Columbia
NCT07175077
Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy
BioNTech SE
NCT06449209
TH1902 in Patients With Advanced Solid Tumors
Theratechnologies
NCT04706962
ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung Cancers
Washington University School of Medicine
NCT05616624
Radiotherapy and Durvalumab/Durvalumab Combo (Tremelimumab/Olaparid) for Small Cell Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute
NCT03923270
Targeted Therapy With CDK4/6 Inhibitors in Chemo-Refractory, Rb Wild-Type Extensive SCLC
Case Comprehensive Cancer Center
NCT04010357
A Study of SY 5609, a Selective CDK7 Inhibitor, in Advanced Solid Tumors
Syros Pharmaceuticals
NCT04247126
Hippocampal Prophylactic Cranial Irradiation for Small Cell Lung Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT01797159
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 8 |
| Phase 2 | 8 |
| Phase 3 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Small-cell Lung Cancer Trial Landscape
ClinicalTrials.gov lists 26 US studies indexed under Small-cell Lung Cancer, and 19 of those are currently open to recruitment — roughly 73% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Small-cell Lung Cancer shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 16 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Small-cell Lung Cancer is led by Washington University School of Medicine with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 26 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Small-cell Lung Cancer?
PlainTrial tracks 26 US clinical trials for Small-cell Lung Cancer, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Small-cell Lung Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.