Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
HIV: early-phase trial registry
109 of 304 indexed HIV trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #27 of 28,707 conditions by registered trial count.
304 US clinical trials · 109 currently recruiting · #27 of 28,707 conditions by registered trial count
HIV: 304 US clinical trials tracked, 109 recruiting.
HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.
Enrollment posture brief
Registry condition hiv
OPEN 109 | RECR 36% | LATE 25 | EARLY 64 | RANK #27 | SPON 24
Volume-matched condition peers
Nearest open-share peer: Acute Respiratory Failure (36% recruiting · 14 trials)
HIV lists 109 open slots (36% of 304 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for HIV on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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HIV recruits in line with its size-band peers.
109 of 304 indexed trials (35.9%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of HIV trials is spread across many organizations.
National Institute of Allergy and Infectious Diseases (NIAID) accounts for 24 of 304 trials (7.9%). 115 distinct sponsors appear on at least one study for this condition label.
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Typical HIV enrolment sits around 100 participants.
Median target enrolment is 100 among the 304 trials that report a genuine target (sentinel values excluded). 142 of those (46.7%) plan for fewer than 100 participants.
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HIV research is mostly interventional.
252 interventional and 52 observational studies make up this index (82.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
304 total, page 1 of 7
Five Point Initiative: A Bundled Implementation Strategy to Address the HIV Epidemic in Black Communities
University of Miami
NCT06062342
The DC Cohort Longitudinal HIV Status Neutral Study
George Washington University
NCT01206920
Effectiveness of Relationship Education for Reducing HIV Incidence Among SGM
Northwestern University
NCT05678556
HOTSPOT Study: Implement and Evaluate the PrEP (Pre-exposure Prophylaxis) Implementation Strategy
University of Texas Southwestern Medical Center
NCT06919419
Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00114647
ACCESS: Accelerating Cervical Cancer Elimination Through the Integration of Screen-and-treat Services
University of California, San Diego
NCT06128304
Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001281
Collection of Blood for Multiple Collaborative Studies
University of California, San Francisco
NCT01336855
Peru Decentralized HIV Care
Yale University
NCT05910268
Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer
National Cancer Institute (NCI)
NCT00006518
Ending the HIV Epidemic for Patient and Healthcare Staff Well-being
Columbia University
NCT05785169
Leukapheresis Procedures to Obtain Plasma and Lymphocytes for Research Studies on Antiretroviral Naive HIV-1 Research Participants
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00039689
Finishing HIV Project
University of Miami
NCT06406049
Clinical and Immunologic Monitoring of Patients With Known or Suspected HIV Infection
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00789009
#ChopViolence/#ChopHIV
Hektoen Institute for Medical Research
NCT04769492
Gathering Online for Dialogue and Discussion to Enhance Social Support
RTI International
NCT05753683
Leukapheresis to Obtain Plasma or Lymphocytes for Studies of HIV-infected Patients, Including Long-term Non-progressors
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00029445
PrEP Readiness Interventions for Sustained Motivation (PRISM)
Florida International University
NCT06637436
HIV Prevention Intervention for Latino Male Couples
University of Central Florida
NCT06131931
Viral Load in Blood and Lymph Tissues in People Living With HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001316
Multidisciplinary Low-Barrier and Mobile HIV Care to Improve Retention and Viral Suppression: Stakeholder-Engaged Design and Evaluation
University of California, San Francisco
NCT05887557
Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes
Montefiore Medical Center
NCT05642715
Telehealth for Pain and Unhealthy Drinking Among PLWH
Boston University
NCT05503173
Behavioral Activation and Risk Reduction for Stimulant Use Among Sexually Active Adolescents and Young Adults
Westat
NCT06444360
Effectiveness and Implementation of Text Messaging to Improve HIV Testing in Adolescents
Northwestern University
NCT06096519
Alcohol and "Heat of the Moment" Sexual Decision Making
Boston University Charles River Campus
NCT05729256
Testing Two Interventions to Improve Health Outcomes and Quality of Life Among Rural Older Adults Living With HIV
Medical College of Wisconsin
NCT06269081
J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations
University of Chicago
NCT06477588
A Remotely Delivered Tai Chi/Qigong Intervention for Older People Living With HIV
Florida International University
NCT06586619
Telemedicine for Unhealthy Alcohol Use in Persons Living With HIV Using CETA
University of Alabama at Birmingham
NCT04955795
Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care
Johns Hopkins University
NCT05241990
PRIDE III Prison Interventions and HIV Prevention Collaboration
Yale University
NCT06962033
The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
University of Miami
NCT05453513
The Collaborative Care PrTNER Study
Children's Hospital of Philadelphia
NCT06585631
Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ...
National Cancer Institute (NCI)
NCT05470491
Text Education About Cardiovascular Health and HIV (TEACH-HIV)
University of California, San Francisco
NCT05642858
Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders
Boston University
NCT05934305
Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP
University of Connecticut
NCT05669534
Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women
Yale University
NCT05547048
Striving Towards EmPowerment and Medication Adherence R01
University of Miami
NCT06463886
Joining Under-connected Networks to Optimize "Salud" (Health) ("JUNTOS")
University of Miami
NCT06432725
Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma
University of Oklahoma
NCT05208671
Optimizing Tobacco Treatment Delivery for People Living With HIV
Medical University of South Carolina
NCT05019495
Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
Wake Forest University Health Sciences
NCT04810858
Prevention Ambassadors: Intervention to Promote HIV Service Engagement in the Networks of SSP Clients
San Diego State University
NCT06848686
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
Icahn School of Medicine at Mount Sinai
NCT04353778
Transitional Housing and HIV Health
University of Pennsylvania
NCT06829394
Skeletal Muscle Energetics and Fatiguability in Older Individuals
Johns Hopkins University
NCT04142047
Wellness Intervention for Smoking and HIV
University of Arizona
NCT04725617
A Study of VRC07-523LS, PGT121.414.LS, and PGDM1400LS Broadly Neutralizing Monoclonal Antibodies Given Intravenously in Adult Participants Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT06812494
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 32 |
| Phase 2 | 32 |
| Phase 3 | 12 |
| Phase 4 | 13 |
Top Sponsors
Named interventions
Most-linked intervention names on HIV records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on HIV trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this HIV page
304 registered trials, 109 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 109 HIV trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Allergy and Infectious Diseases (NIAID) sponsors the most HIV trials on record, review their full trial history before evaluating a specific study. See National Institute of Allergy and Infectious Diseases (NIAID)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This HIV condition card totals 304 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.