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NCT05934305 · ClinicalTrials.gov registry record · NA
Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders
A NA study of HIV and Substance Use Disorders, sponsored by Boston University.
- Recruiting
- Registry status
- NA
- Development phase
- 256
- Enrollment target
- 2
- Study locations
NCT05934305: Recruiting NA study of HIV and Substance Use Disorders, sponsored by Boston University.
NCT05934305 is a NA study of HIV and Substance Use Disorders that is actively recruiting participants, run by Boston University. The registered enrollment target is 256 participants, below the 439-participant average among 303 other HIV trials with a reported enrollment target (42% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05934305, a NA study of HIV and Substance Use Disorders, is actively recruiting participants, sponsored by Boston University.
- RECRUITING
- Registry status
- NA
- Development phase
- 256 participants
- Enrollment target
- 2
- Study locations
Study Summary
People living with HIV and substance use disorders (SUDs) are less likely to be virally suppressed, which can lead to HIV transmission and negative health outcomes. This hybrid type 1 study will assess the efficacy, mechanisms, as well as facilitators and barriers to implementing the MATTER intervention, a virtually delivered 5-session text-enhanced psychobehavioral intervention designed to facilitate viral suppression by addressing internalized stigma and shame as barriers to engagement in HIV care among individuals living with HIV and SUDs in two locations with different levels of HIV resources (i.e., the Boston, Massachusetts and Miami, Florida metro areas). MATTER aims to mitigate the negative behavioral consequences of internalized stigma and shame on viral suppression by a) developing behavioral self-care goal setting skills and related self-efficacy, b) increasing metacognitive awareness (i.e., non-judgmental awareness of emotions and cognitions), and c) teaching and reinforcing compassionate self-restructuring (i.e., self- compassion), in addition to providing access to phone-based resource navigation. Scalable interventions such as MATTER are essential to our efforts to end the HIV epidemic in high priority regions.
Primary Outcome
Compare the proportion of participants randomized to the intervention to the proportion of those randomized to the time-matched control condition who are virally suppressed at the 12 months follow up visit.
Conditions Studied
Interventions
- BEHAVIORAL Control Condition
- BEHAVIORAL Matter Intervention
Study Locations (2)
Florida
- Florida International University - Miami
Massachusetts
- Fenway Health - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 256 participants |
| Start Date | 2025-03-12 |
| Est. Completion | 2028-07 |
| Phase | NA |
What NCT05934305 shows while recruiting
NCT05934305 is an interventional study that assigns participants to a tested intervention. The registered 256 participants enrollment target is mid-sized for trials with a published cap, below the 439-participant average among 303 other HIV trials with a reported enrollment target (42% lower).
The record links to 2 conditions, with HIV appearing as the primary indexed condition, and to 2 interventions - of which Control Condition is the first listed.
NCT05934305 reports a single indexed study location in Florida, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05934305 about?
NCT05934305 is a clinical study titled "Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders". People living with HIV and substance use disorders (SUDs) are less likely to be virally suppressed, which can lead to HIV transmission and negative health outcomes. This hybrid type 1 study will assess the efficacy, mechanisms, as well as facilitators and barriers to implementing the MATTER interven...
What is the current status of trial NCT05934305?
This trial is currently recruiting. It is a NA study. The enrollment target is 256 participants. The study started on 2025-03-12. Estimated completion is 2028-07.
What conditions does trial NCT05934305 study?
This clinical trial studies the following conditions: HIV, Substance Use Disorders.
What interventions are being tested in trial NCT05934305?
The interventions under investigation include: Control Condition (BEHAVIORAL), Matter Intervention (BEHAVIORAL).
Who is sponsoring clinical trial NCT05934305?
This trial is sponsored by Boston University, which has 185 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05934305 being conducted?
This trial has 2 study locations across Florida, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for HIV
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05934305's enrollment target sits among peer trials
256 81st of 303 higher than 219 of 303 other HIV trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other HIV trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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