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ClinicalTrials.gov 78 recruiting now official registry

Glioblastoma clinical trials

78 of 200 indexed Glioblastoma trials are currently recruiting.

200 US clinical trials · 78 currently recruiting

Glioblastoma is the subject of 200 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 148 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 10 of these trials.

The research picture

Glioblastoma has 200 registered US clinical trials, 78 of them open to new participants right now, about 39% of the total.

78
recruiting participants now
39%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
10
top sponsor: National Cancer Institute (NCI)
Phase 187Phase 261Phase 313Phase 42

Active & Recent Trials

200 total, page 4 of 4

ACTIVE NOT RECRUITING Phase 1 9 participants

Neoantigen-based Personalized DNA Vaccine in Patients With Newly Diagnosed, Unmethylated Glioblastoma

Washington University School of Medicine

NCT04015700

ACTIVE NOT RECRUITING Phase 1 4 participants

A Phase 1b / 2 Drug Resistant Immunotherapy With Activated, Gene Modified Allogeneic or Autologous γδ T Cells (DeltEx) in Combination With Maintenance Temozolomide in Subjects With Recurrent or Newly Diagnosed Glioblastoma

In8bio

NCT05664243

ACTIVE NOT RECRUITING Phase 1 2 participants

Short Course Chemo-Radiation Therapy for Patients With Newly Diagnosed Glioblastoma

John Flickinger

NCT04019262

COMPLETED Phase 3 921 participants

A Study of Bevacizumab (Avastin®) in Combination With Temozolomide and Radiotherapy in Participants With Newly Diagnosed Glioblastoma

Hoffmann-La Roche

NCT00943826

COMPLETED Phase 3 545 participants

Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status

EMD Serono

NCT00689221

COMPLETED 276 participants

An Observational Pilot Study Evaluating the Feasibility of Conducting Genome-Wide Association Studies Utilizing Subject Provided Information in Subjects With Locally Recurrent or MBC, MCRC, MNSCLC, RGBM or MRCC Treated With Avastin (Bevacizumab) (InVite)

Genentech

NCT01598597

COMPLETED Phase 1 271 participants

Study of CC-122 to Evaluate the Safety, Tolerability, and Effectiveness for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma, or Multiple Myeloma

Celgene

NCT01421524

COMPLETED Phase 3 260 participants

A Trial of Enzastaurin Plus Temozolomide During and Following Radiation Therapy in Patients With Newly Diagnosed Glioblastoma With or Without the Novel Genomic Biomarker, DGM1

Denovo Biopharma

NCT03776071

COMPLETED Phase 2 159 participants

Phase 2 Study of Durvalumab (MEDI4736) in Patients With Glioblastoma

Ludwig Institute for Cancer Research

NCT02336165

COMPLETED Phase 2 137 participants

Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors

National Cancer Institute (NCI)

NCT01609790

COMPLETED Phase 2 127 participants

A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma

Celldex Therapeutics

NCT01498328

COMPLETED Phase 2 125 participants

Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas

Duke University

NCT00597402

COMPLETED Phase 1 83 participants

A Phase 1 Trial of CBL0137 in Patients With Metastatic or Unresectable Advanced Solid Neoplasm

Incuron

NCT01905228

COMPLETED Phase 2 83 participants

Standard Dose Bevacizumab Versus Low Dose Bevacizumab Plus Lomustine (CCNU) for Recurrent Glioblastoma Multiforme (GBM)

M.D. Anderson Cancer Center

NCT01067469

COMPLETED Phase 2 80 participants

Pembrolizumab +/- Bevacizumab for Recurrent GBM

Dana-Farber Cancer Institute

NCT02337491

COMPLETED Phase 1 78 participants

Ph I Gleevec in Combo w RAD001 + Hydroxyurea for Pts w Recurrent MG

Annick Desjardins

NCT00613132

COMPLETED Phase 1 74 participants

Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma

National Cancer Institute (NCI)

NCT01849146

COMPLETED Phase 2 74 participants

Study of Bevacizumab Plus Temodar and Tarceva in Patients With Glioblastoma or Gliosarcoma

University of California, San Francisco

NCT00525525

COMPLETED Phase 1 62 participants

Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas

Katy Peters

NCT00610571

COMPLETED Phase 1 59 participants

Safety and Efficacy of Trans Sodium Crocetinate (TSC) With Radiation and Temozolomide in Newly Diagnosed Glioblastoma

Diffusion Pharmaceuticals

NCT01465347

COMPLETED Phase 2 58 participants

PF-00299804 in Adult Patients With Relapsed/Recurrent Glioblastoma

Massachusetts General Hospital

NCT01112527

COMPLETED Phase 2 56 participants

Phase II Avastin + Bortezomib for Patients With Recurrent Malignant Glioma

Duke University

NCT00611325

COMPLETED Phase 2 50 participants

Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma

Jonsson Comprehensive Cancer Center

NCT01149850

COMPLETED Phase 1 37 participants

PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas

Duke University

NCT00612651

COMPLETED Phase 2 36 participants

Bavituximab With Radiation and Temozolomide for Patients With Newly Diagnosed Glioblastoma

Massachusetts General Hospital

NCT03139916

COMPLETED Phase 1 36 participants

Evaluation of Ad-RTS-hIL-12 + Veledimex in Subjects With Recurrent or Progressive Glioblastoma, a Substudy to ATI001-102

Alaunos Therapeutics

NCT03679754

COMPLETED Phase 2 35 participants

TH-302 in Combination With Bevacizumab for Glioblastoma

The University of Texas Health Science Center at San Antonio

NCT02342379

COMPLETED Phase 2 30 participants

A Phase II Trial of Sutent (Sunitinib; SU011248) for Recurrent Anaplastic Astrocytoma and Glioblastoma

H. Lee Moffitt Cancer Center and Research Institute

NCT00606008

COMPLETED Phase 3 30 participants

Comparison of TransMID vs Standard Treatment of Cancerous Brain Tumors

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00088400

COMPLETED Phase 2 28 participants

Phase 2 Study to Investigate the Efficacy and Safety of Aldoxorubicin in Subjects With Glioblastoma

ImmunityBio

NCT02014844

COMPLETED Phase 2 25 participants

LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma

Istari Oncology

NCT04479241

COMPLETED Phase 2 23 participants

Study of Lenalidomide and XRT in Patients With Newly Diagnosed Glioblastoma Multiforme

Dana-Farber Cancer Institute

NCT00165477

COMPLETED Phase 2 22 participants

A Phase 2 Evaluation of TRC105 In Combination With Bevacizumab in Patients With Glioblastoma

Tracon Pharmaceuticals

NCT01564914

COMPLETED Early Phase 1 21 participants

Disulfiram in Treating Patients With Glioblastoma Multiforme After Radiation Therapy With Temozolomide

Washington University School of Medicine

NCT01907165

COMPLETED NA 20 participants

Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption

InSightec

NCT03551249

COMPLETED Phase 1 19 participants

A Phase I Trial of Vorinostat in Combination With Bevacizumab & Irinotecan in Recurrent Glioblastoma

H. Lee Moffitt Cancer Center and Research Institute

NCT00762255

COMPLETED 19 participants

Biomarkers for Prognosis of Glioblastoma (GBM)

University of Nebraska

NCT01493219

COMPLETED Phase 1 19 participants

A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)

Children's Hospital Medical Center, Cincinnati

NCT03355794

COMPLETED Phase 1 17 participants

Dendritic Cell Vaccination With Standard Postoperative Chemoradiation for the Treatment of Adult Glioblastoma

The Cooper Health System

NCT04552886

COMPLETED Phase 2 17 participants

Trial of Ponatinib in Patients With Bevacizumab-Refractory Glioblastoma

Dana-Farber Cancer Institute

NCT02478164

COMPLETED Phase 1 15 participants

Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors

University of Florida

NCT01111097

COMPLETED Phase 1 14 participants

ASP8374 + Cemiplimab in Recurrent Glioma

Dana-Farber Cancer Institute

NCT04826393

COMPLETED Phase 1 13 participants

Avelumab With Laser Interstitial Therapy for Recurrent Glioblastoma

Icahn School of Medicine at Mount Sinai

NCT03341806

COMPLETED Phase 1 12 participants

BPM31510 in Treating Patients With Recurrent High-Grade Glioma Previously Treated With Bevacizumab

Seema Nagpal

NCT03020602

COMPLETED NA 12 participants

Feasibility Study of Modified Atkins Ketogenic Diet in the Treatment of Newly Diagnosed Malignant Glioma

University of Cincinnati

NCT03278249

COMPLETED NA 12 participants

Accurate DCE-MRI Measurement of Glioblastoma Using Point-of-care Portable Perfusion Phantom

University of Alabama at Birmingham

NCT05140902

COMPLETED NA 10 participants

Palliative 4pi Radiotherapy in Treating Patients With Recurrent Glioblastoma Multiforme

Jonsson Comprehensive Cancer Center

NCT02575027

COMPLETED Phase 2 10 participants

Tivozanib for Recurrent Glioblastoma

Massachusetts General Hospital

NCT01846871

COMPLETED Phase 1 6 participants

Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2

City of Hope Medical Center

NCT01082926

COMPLETED Phase 2 3 participants

A Study of Subcutaneous Bevacizumab in Relapsed / Progressive Glioblastoma

Emory University

NCT02157103

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Phase Distribution

PhaseTrial count
Phase 1 87
Phase 2 61
Phase 3 13
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glioblastoma Trial Landscape

200 indexed Glioblastoma studies · 78 recruiting (39%).

Phase mix: 15 late (III/IV) vs 148 early (I/II).

Top sponsor: National Cancer Institute (NCI) (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glioblastoma?

PlainTrial tracks 200 US clinical trials for Glioblastoma, of which 78 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glioblastoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.