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NCT00525525 · ClinicalTrials.gov registry record · Phase 2
Study of Bevacizumab Plus Temodar and Tarceva in Patients With Glioblastoma or Gliosarcoma
A Phase 2 study of Glioblastoma and Gliosarcoma, sponsored by University of California, San Francisco.
- Completed
- Registry status
- Phase 2
- Development phase
- 74
- Enrollment target
- 1
- Study location
NCT00525525: Completed Phase 2 study of Glioblastoma and Gliosarcoma, sponsored by University of California, San Francisco.
NCT00525525 is a Phase 2 study of Glioblastoma and Gliosarcoma that has completed, run by University of California, San Francisco. The registered enrollment target is 74 participants, below the 109-participant average among 199 other Glioblastoma trials with a reported enrollment target (32% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00525525, a Phase 2 study of Glioblastoma and Gliosarcoma, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 74 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a phase II study of Bevacizumab plus Temodar and Tarceva in patients with non-progressive glioblastoma or gliosarcoma. Patients must have stable disease immediately following a standard course of up-front radiotherapy and Temodar. All patients will receive Bevacizumab, Temodar and Tarceva. A total of 60 patients will be enrolled. Our hypothesis is that the combination of Bevacizumab plus Temodar and Tarceva will increase survival over that seen in historical controls who have newly diagnosed, non-progressive glioblastoma or gliosarcoma following radiotherapy plus Temodar and use Temodar alone.
Primary Outcome
Overall survival was defined from the date of diagnosis to date of death from any cause
Conditions Studied
Interventions
- DRUG Bevacizumab
- DRUG Temozolomide
- DRUG Tarceva
Study Locations (1)
California
- University of California San Francisco - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 74 participants |
| Start Date | 2007-09 |
| Est. Completion | 2013-05 |
| Phase | Phase 2 |
What the finished NCT00525525 record still lists
NCT00525525 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 74 participants, a relatively small participant target, below the 109-participant average among 199 other Glioblastoma trials with a reported enrollment target (32% lower).
The record links to 2 conditions, with Glioblastoma appearing as the primary indexed condition, and to 3 interventions - of which Bevacizumab is the first listed.
NCT00525525 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT00525525 about?
NCT00525525 is a clinical study titled "Study of Bevacizumab Plus Temodar and Tarceva in Patients With Glioblastoma or Gliosarcoma". This is a phase II study of Bevacizumab plus Temodar and Tarceva in patients with non-progressive glioblastoma or gliosarcoma. Patients must have stable disease immediately following a standard course of up-front radiotherapy and Temodar. All patients will receive Bevacizumab, Temodar and Tarceva. A...
What is the current status of trial NCT00525525?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 74 participants. The study started on 2007-09. Estimated completion is 2013-05.
What conditions does trial NCT00525525 study?
This clinical trial studies the following conditions: Glioblastoma, Gliosarcoma.
What interventions are being tested in trial NCT00525525?
The interventions under investigation include: Bevacizumab (DRUG), Temozolomide (DRUG), Tarceva (DRUG).
Who is sponsoring clinical trial NCT00525525?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00525525 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00525525's enrollment target sits among peer trials
74 62nd of 199 higher than 136 of 199 other Glioblastoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Glioblastoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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