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Study of CC-122 to Evaluate the Safety, Tolerability, and Effectiveness for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma, or Multiple Myeloma
NCT01421524 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of this first in human study with CC-122 is to assess the safety and action of a new class of experimental drug (Pleiotropic Pathway Modulator) in patients with advanced tumors unresponsive to standard therapies and to determine the appropriate dosing level and regimen for later-stage clinical trials.
Conditions Studied
Interventions
- DRUG CC-122
Study Locations (20)
California
- City of Hope Cancer Center — Duarte
- UCLA Neuro-Oncology Program — Los Angeles
- UCSF Helen Diller Medical Center at Parnassus Heights — San Francisco
Other
- Local Institution - 401 — Brussels
- Local Institution - 400 — Leuven
- Local Institution - 202 — Caen
Michigan
- University Of Michigan Comprehensive Cancer Center — Ann Arbor
- Henry Ford Medical Center - New Center One — Detroit
New York
- Mount Sinai Hospital — New York
- Local Institution - 020 — New York
South Carolina
- MUSC Rheumatology and Immunology Dept. — Charleston
- Greenville Hospital System — Greenville
Texas
- Texas Oncology, PA - Dallas 75246 — Dallas
- South Texas Accelerated Research Therapeutics (START) — San Antonio
Washington
- Swedish Medical Center Cancer Institute Research — Seattle
- Yakima Valley Memorial Hospital/ North Star Lodge — Yakima
Nevada
- Comprehensive Cancer Centers Of Nevada — Las Vegas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 271 participants |
| Start Date | 2011-09-12 |
| Est. Completion | 2023-11-21 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01421524
The ClinicalTrials.gov registry entry for NCT01421524 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 271 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Celgene, which has 73 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 6 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 1 intervention — of which CC-122 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT01421524 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Other, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT01421524 about?
NCT01421524 is a clinical study titled "Study of CC-122 to Evaluate the Safety, Tolerability, and Effectiveness for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma, or Multiple Myeloma". The main purpose of this first in human study with CC-122 is to assess the safety and action of a new class of experimental drug (Pleiotropic Pathway Modulator) in patients with advanced tumors unresponsive to standard therapies and to determine the appropriate dosing level and regimen for later-sta...
What is the current status of trial NCT01421524?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 271 participants. The study started on 2011-09-12. Estimated completion is 2023-11-21.
What conditions does trial NCT01421524 study?
This clinical trial studies the following conditions: Multiple Myeloma, Lymphoma, Glioblastoma, Primary Central Nervous System Lymphoma, Lymphoma, Large B-Cell, Diffuse. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT01421524?
The interventions under investigation include: CC-122 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT01421524?
This trial is sponsored by Celgene, which has 73 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT01421524 being conducted?
This trial has 20 study locations across California, Michigan, Nevada, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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