Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Follicular Lymphoma

Open-data reference.

90 US clinical trials · 49 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 700 participants

A Long-term Extension Study of PCI-32765 (Ibrutinib)

Janssen Research & Development

NCT01804686

RECRUITING Phase 1 614 participants

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

BeOne Medicines

NCT05006716

RECRUITING Phase 3 612 participants

A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.

Epizyme

NCT04224493

RECRUITING 500 participants

Long-term Follow-up Study of Patients Receiving CAR-T Cells

Medical College of Wisconsin

NCT03375619

RECRUITING Phase 3 400 participants

A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)

Celgene

NCT06911502

RECRUITING Phase 3 375 participants

A Study of Reduced Dose Radiation Therapy for People With B-Cell Lymphomas

Memorial Sloan Kettering Cancer Center

NCT07029217

RECRUITING Phase 1 317 participants

A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma

AstraZeneca

NCT04594642

RECRUITING 300 participants

A Study to Patients With Relapsed/Refractory Follicular Lymphoma Treated With Liso-cel (Lisocabtagene Maraleucel) in the Post Marketing Setting

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

NCT06794268

RECRUITING 300 participants

Optimizing ctDNA-based MRD Assessment in DLBCL, MCL, and FL Patients Undergoing CAR Therapy

Adaptive Biotechnologies

NCT05255354

RECRUITING 200 participants

Evaluation of Human Immune Responses Vaccination in Patients With Lymphoma

Emory University

NCT03501576

RECRUITING 200 participants

Clonal Evolution in Follicular Lymphoma

National Cancer Institute (NCI)

NCT03190928

RECRUITING NA 200 participants

Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

Masonic Cancer Center, University of Minnesota

NCT01962636

RECRUITING Phase 1 168 participants

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

OncoNano Medicine

NCT06022029

RECRUITING Phase 1 154 participants

A Study to Assess the Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-319 Moves Through the Bodies of Adult Participants With Relapsed or Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), or Chronic Lymphocytic Leukemia (CLL)

AbbVie

NCT05512390

RECRUITING Phase 2 152 participants

A Study of Mosunetuzumab Alone or With Zanubrutinib in People With Follicular Lymphoma

Memorial Sloan Kettering Cancer Center

NCT05389293

RECRUITING Phase 1 148 participants

AutologousCD22 Chimeric Antigen Receptor (CAR)T Cells in w/Recurrent/Refractory B Cell Lymphomas

Stanford University

NCT06340737

RECRUITING Phase 1 140 participants

IKS03 in Patients With Advanced B Cell Non-Hodgkin Lymphomas

Iksuda Therapeutics

NCT05365659

RECRUITING Phase 1 120 participants

A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies

CRISPR Therapeutics

NCT05643742

RECRUITING Phase 1 120 participants

AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

Carna Biosciences

NCT05602363

RECRUITING Phase 1 100 participants

CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies

Medical College of Wisconsin

NCT04186520

RECRUITING Phase 2 100 participants

Epcoritamab and Rituximab for First-line Follicular Lymphoma

Reid Merryman, MD

NCT05783609

RECRUITING Phase 2 100 participants

Loncastuximab Tesirine in Combination With Rituximab in Patients With Relapsed or Refractory Follicular Lymphoma

Juan P. Alderuccio, MD

NCT04998669

RECRUITING Phase 1 100 participants

Measuring Cell-Free DNA (cfDNA) Levels in People With Follicular Lymphoma

Memorial Sloan Kettering Cancer Center

NCT04468841

RECRUITING Phase 1 98 participants

Study of SGR-1505 in Mature B-Cell Neoplasms

Schrödinger

NCT05544019

RECRUITING Phase 1 80 participants

A Novel Vaccine (EO2463) as Monotherapy and in Combination, for Treatment of Patients With Indolent Non-Hodgkin Lymphoma

Enterome

NCT04669171

RECRUITING Phase 2 65 participants

HM2023-43:Ph 2 Trial of Tafasitamab With Lenalidomide+Rituximab in Treatment-naive FL and MZL

Masonic Cancer Center, University of Minnesota

NCT06792825

RECRUITING Phase 1 60 participants

Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

Newave Pharmaceutical

NCT04775745

RECRUITING Phase 2 52 participants

Mosunetuzumab With Lenalidomide Augmentation as First-line Therapy for Follicular and Marginal Zone Lymphoma

Brown University

NCT04792502

RECRUITING Phase 2 50 participants

Tazemetostat and Mosunetuzumab in Untreated Follicular Lymphoma

Weill Medical College of Cornell University

NCT05994235

RECRUITING 45 participants

Vaccine Responses in Patient With Multiple Myeloma and Non-Hodgkin Lymphoma After CAR-T Treatment

OHSU Knight Cancer Institute

NCT06784167

RECRUITING Phase 2 45 participants

Epco, Zanu, Ritux for R/R FL or MZL

Reid Merryman, MD

NCT06563596

RECRUITING Phase 2 43 participants

Rituximab and Zanubrutinib in Patients With Indolent B-cell Lymphomas

H. Lee Moffitt Cancer Center and Research Institute

NCT06350318

RECRUITING Phase 1 42 participants

ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies

Acepodia Biotech

NCT05653271

RECRUITING Early Phase 1 42 participants

64Cu-LLP2A for Imaging Hematologic Malignancies

Washington University School of Medicine

NCT06636175

RECRUITING NA 40 participants

Combating Cancer-Related Fatigue: A Personalized Supportive Care Program

UNC Lineberger Comprehensive Cancer Center

NCT06860880

RECRUITING Phase 1 38 participants

Tazemetostat and Venetoclax in Relapsed/Refractory Non-Hodgkin Lymphoma

Weill Medical College of Cornell University

NCT05618366

RECRUITING Phase 2 36 participants

Phase 2 Trial of Obinutuzumab and CC-99282 for Patients With Previously Untreated High Tumor Burden Follicular Lymphoma

M.D. Anderson Cancer Center

NCT06108232

RECRUITING Phase 1 36 participants

Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma

C. Babis Andreadis

NCT04545762

RECRUITING Phase 2 35 participants

Epcoritamab in Patients With Follicular Lymphoma Not Accomplishing a CR With Upfront Chemoimmunotherapy

Beth Israel Deaconess Medical Center

NCT06510361

RECRUITING Phase 2 35 participants

Odronextamab in Low Tumor Volume Advanced FL

Gottfried von Keudell, MD PhD

NCT07128641

RECRUITING Phase 1 32 participants

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

Vironexis Biotherapeutics

NCT06533579

RECRUITING Phase 2 30 participants

Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia

John Lister

NCT05281809

RECRUITING Phase 2 28 participants

Emapalumab Prevention of CAR-T Cell Associated Toxicities

Marcela V. Maus, M.D.,Ph.D.

NCT06550141

RECRUITING Phase 1 24 participants

CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

Marcela V. Maus, M.D.,Ph.D.

NCT06026319

RECRUITING Phase 2 20 participants

A Phase II Study of Axicabtagene Ciloleucel, an Anti-CD19 Chimeric Antigen Receptor (CAR) Tcell Therapy, in Combination With Radiotherapy (RT) in Relapsed/Refractory Follicular Lymphoma

M.D. Anderson Cancer Center

NCT06043323

RECRUITING Phase 1 20 participants

Study of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

UNC Lineberger Comprehensive Cancer Center

NCT04223765

RECRUITING Phase 1 18 participants

SynKIR-310 for Relapsed/Refractory B-NHL

Verismo Therapeutics

NCT06544265

RECRUITING Phase 1 15 participants

A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas

Weill Medical College of Cornell University

NCT05934838

RECRUITING Phase 1 12 participants

LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies

Medical College of Wisconsin

NCT05990465

ACTIVE NOT RECRUITING Phase 3 654 participants

A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.

Incyte Corporation

NCT04680052

ACTIVE NOT RECRUITING Phase 1 543 participants

Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)

Genmab

NCT04663347

ACTIVE NOT RECRUITING Phase 1 237 participants

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Participants With Follicular Lymphoma

Hoffmann-La Roche

NCT04246086

ACTIVE NOT RECRUITING Phase 2 223 participants

A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)

Merck Sharp & Dohme

NCT05458297

ACTIVE NOT RECRUITING Phase 1 190 participants

A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)

NCT03162536

ACTIVE NOT RECRUITING Phase 2 139 participants

Study of Abexinostat in Patients With Relapsed or Refractory Follicular Lymphoma

Xynomic Pharmaceuticals

NCT03600441

ACTIVE NOT RECRUITING Phase 2 47 participants

Glofit and Obin in Follicular Lymphoma and Marginal Zone Lymphoma

Reid Merryman, MD

NCT05783596

ACTIVE NOT RECRUITING Phase 1 43 participants

Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

University of Michigan Rogel Cancer Center

NCT03842696

ACTIVE NOT RECRUITING Phase 1 42 participants

A Study of Tazemetostat With Rituximab and Abbreviated Bendamustine in the Frontline Treatment of High Tumor Burden Follicular Lymphoma

Vaishalee Kenkre

NCT05551936

ACTIVE NOT RECRUITING Phase 1 36 participants

Autologous CD19 CAR-T Cell Therapy (SYNCAR-001) + Orthogonal IL-2 (STK-009) in Subjects With CD19+ Hematologic Malignancies

Synthekine

NCT05665062

ACTIVE NOT RECRUITING Phase 2 34 participants

Mosunetuzumab and Polatuzumab Vedotin for Untreated Follicular Lymphoma

Washington University School of Medicine

NCT05410418

ACTIVE NOT RECRUITING Phase 2 33 participants

Ixazomib Citrate and Rituximab in Treating Patients With Indolent B-cell Non-Hodgkin Lymphoma

University of Washington

NCT02339922

ACTIVE NOT RECRUITING Phase 2 33 participants

Response-Adapted Therapy With Copanlisib and Rituximab in Untreated Follicular Lymphoma

National Cancer Institute (NCI)

NCT03789240

ACTIVE NOT RECRUITING Phase 1 33 participants

Low Dose Radiation as Bridging Therapy in Relapsed B-Cell Non-Hodgkin Lymphoma

University of Nebraska

NCT05621096

ACTIVE NOT RECRUITING Phase 1 30 participants

A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies

Bio-Path Holdings

NCT04072458

ACTIVE NOT RECRUITING Phase 1 27 participants

Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT03884998

ACTIVE NOT RECRUITING Phase 2 26 participants

Optimizing Cellular and Humoral Immunity by Vaccinating With PCV13 Before and After CAR-T Therapy

H. Lee Moffitt Cancer Center and Research Institute

NCT04745559

ACTIVE NOT RECRUITING Phase 1 20 participants

Personalized Neoantigen Cancer Vaccine + Pembrolizumab After Rituximab for Follicular Lymphoma

Dana-Farber Cancer Institute

NCT03361852

ACTIVE NOT RECRUITING Phase 1 16 participants

Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant

M.D. Anderson Cancer Center

NCT03622788

COMPLETED Phase 3 1,030 participants

Combined Rituximab and Lenalidomide Treatment for Untreated Patients With Follicular Lymphoma

Celgene

NCT01476787

COMPLETED Phase 3 394 participants

A Study Of PF-05280586 (Rituximab-Pfizer) Or MabThera® (Rituximab-EU) For The First-Line Treatment Of Patients With CD20-Positive, Low Tumor Burden, Follicular Lymphoma (REFLECTIONS B328-06)

Pfizer

NCT02213263

COMPLETED Phase 1 134 participants

Anti-CD22 Chimeric Receptor T Cells in Pediatric and Young Adults With Recurrent or Refractory CD22-expressing B Cell Malignancies

National Cancer Institute (NCI)

NCT02315612

COMPLETED Phase 2 125 participants

Efficacy and Safety Study of Idelalisib in Participants With Indolent B-Cell Non-Hodgkin Lymphomas

Gilead Sciences

NCT01282424

COMPLETED Phase 1 96 participants

First in Human Study to Determine the Safety, Tolerability and Preliminary Efficacy of an Anti-CXCR4 Antibody in Subjects With Acute Myelogenous Leukemia and Selected B-cell Cancers

Bristol-Myers Squibb

NCT01120457

COMPLETED Phase 1 91 participants

A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)

VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT03833180

COMPLETED Phase 2 73 participants

A Phase II Study of VELCADE (Bortezomib) in Combination With Bendamustine and Rituximab in Subjects With Relapsed or Refractory Follicular Lymphoma

Millennium Pharmaceuticals

NCT00636792

COMPLETED Phase 2 66 participants

VELCADE® (Bortezomib) With Rituximab in Subjects With Relapsed or Refractory Indolent B-Cell Lymphoma

Millennium Pharmaceuticals

NCT00085696

COMPLETED Phase 1 60 participants

Fludarabine, Bendamustine, and Rituximab in Treating Participants With Lymphoid Cancers Undergoing Stem Cell Transplant

M.D. Anderson Cancer Center

NCT00880815

COMPLETED Phase 1 50 participants

Oral Clofarabine for Relapsed/Refractory Non-Hodgkin Lymphoma

Massachusetts General Hospital

NCT00644189

COMPLETED Phase 2 50 participants

Phase II Safety and Efficacy Study of Single-agent AT-101 in Patients With Relapsed or Refractory B-cell Malignancies

Ascenta Therapeutics

NCT00275431

COMPLETED NA 46 participants

Use of a Patient Preferences Shared Decision-Making Encounter Tool in Clinical Practice for Patients With DLBCL and FL

Carevive Systems

NCT04160442

COMPLETED NA 45 participants

Evaluating the Feasibility of a Digital Health Coaching Program for Individuals Following CAR T Therapy

Pack Health

NCT05064787

COMPLETED Phase 1 39 participants

Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL

Masonic Cancer Center, University of Minnesota

NCT03019666

COMPLETED Phase 1 37 participants

A Phase I/II Trial of VR-CHOP in Lymphoma Patients

Emory University

NCT00634179

COMPLETED Phase 1 26 participants

BR101801 in Adult Patients With Advanced Hematologic Malignancies(Phase I)

Boryung Pharmaceutical Co.

NCT04018248

COMPLETED Phase 1 24 participants

Vaccination for the Treatment of Previously Untreated or Relapsed Follicular Lymphoma

Dana-Farber Cancer Institute

NCT00487305

COMPLETED Phase 2 23 participants

Safety & Efficacy Study of AT-101 in Combination w/ Rituximab in Previously Untreated Grade I-II Follicular Non-Hodgkin's Lymphoma

Ascenta Therapeutics

NCT00440388

COMPLETED Phase 2 22 participants

Imexon for Relapsed Follicular and Aggressive Lymphomas

University of Rochester

NCT01314014

COMPLETED Phase 1 11 participants

Venetoclax With Obinutuzumab and Magrolimab (VENOM) in Relapsed and Refractory Indolent B-cell Malignancies

National Cancer Institute (NCI)

NCT04599634

COMPLETED NA 10 participants

Adaptive Bridging RT in R/R B-cell Lymphoma (Pre-CAR T)

Massachusetts General Hospital

NCT06004167

COMPLETED Phase 1 6 participants

TC-110 T Cells in Adults With Relapsed or Refractory Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia

TCR2 Therapeutics

NCT04323657

Phase Distribution

PhaseTrial count
Early Phase 1 45
Phase 2 27
Phase 3 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Follicular Lymphoma Trial Landscape

ClinicalTrials.gov lists 90 US studies indexed under Follicular Lymphoma, and 49 of those are currently open to recruitment — roughly 54% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Follicular Lymphoma shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 72 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Follicular Lymphoma is led by M.D. Anderson Cancer Center with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 90 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Follicular Lymphoma?

PlainTrial tracks 90 US clinical trials for Follicular Lymphoma, of which 49 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Follicular Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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