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ClinicalTrials.gov 37 recruiting now official registry

Glioblastoma Multiforme clinical trials

37 of 89 indexed Glioblastoma Multiforme trials are currently recruiting.

89 US clinical trials · 37 currently recruiting

Glioblastoma Multiforme is the subject of 89 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Northwell Health, running 6 of these trials.

The research picture

Glioblastoma Multiforme has 89 registered US clinical trials, 37 of them open to new participants right now, about 42% of the total.

37
recruiting participants now
42%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
6
top sponsor: Northwell Health
Phase 148Phase 226Phase 31

Active & Recent Trials

89 total, page 2 of 2

ACTIVE NOT RECRUITING Early Phase 1 42 participants

Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma

Nader Sanai

NCT05076513

ACTIVE NOT RECRUITING Phase 2 40 participants

Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)

University of Florida

NCT05120284

ACTIVE NOT RECRUITING Early Phase 1 39 participants

Study of DSP-0390 in Patients With Recurrent High-Grade Glioma

Sumitomo Pharma America

NCT05023551

ACTIVE NOT RECRUITING Phase 1 39 participants

IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma

University of Florida

NCT05353530

ACTIVE NOT RECRUITING Phase 1 35 participants

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Children's Oncology Group

NCT04978727

ACTIVE NOT RECRUITING Phase 1 32 participants

Phase I Study of APX005M in Pediatric Central Nervous System Tumors

Pediatric Brain Tumor Consortium

NCT03389802

ACTIVE NOT RECRUITING Phase 1 24 participants

A Phase 1b/2, Multicenter, Open-label Study of ACP-196 in Subjects With Recurrent Glioblastoma Multiforme (GBM)

Acerta Pharma

NCT02586857

ACTIVE NOT RECRUITING Phase 1 17 participants

A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma

Bryan Allen

NCT04900792

ACTIVE NOT RECRUITING Phase 1 16 participants

Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients with Recurrent High-Grade Glioma

Oblato

NCT05561374

ACTIVE NOT RECRUITING Phase 1 16 participants

Trial of Anti-Tim-3 in Combination With Anti-PD-1 and SRS in Recurrent GBM

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03961971

ACTIVE NOT RECRUITING NA 12 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM

Northwell Health

NCT03630289

ACTIVE NOT RECRUITING 2 participants

Spatiotemporal Dimensions of Metabolism in Autochthonous Tumors of GBM Patients

AdventHealth Translational Research Institute

NCT06054529

COMPLETED Phase 1 226 participants

Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma

Celgene

NCT01177397

COMPLETED Phase 2 112 participants

A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas

National Cancer Institute (NCI)

NCT00995007

COMPLETED Phase 1 88 participants

Combination of BKM120 and Bevacizumab in Refractory Solid Tumors and Relapsed/Refractory Glioblastoma Multiforme

SCRI Development Innovations

NCT01349660

COMPLETED Phase 2 81 participants

Cilengitide (EMD 121974) for Recurrent Glioblastoma Multiforme (Brain Tumor)

EMD Serono

NCT00093964

COMPLETED Phase 2 75 participants

6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma Patients

M.D. Anderson Cancer Center

NCT00504660

COMPLETED Phase 2 67 participants

Ph. II Temozolomide + O6-BG in Treatment of Pts w Temozolomide-Resistant Malignant Glioma

Duke University

NCT00613093

COMPLETED Phase 2 63 participants

PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT Methylation

Brown University

NCT01402063

COMPLETED Phase 2 58 participants

PF-00299804 in Adult Patients With Relapsed/Recurrent Glioblastoma

Massachusetts General Hospital

NCT01112527

COMPLETED Phase 2 56 participants

Phase 2 Study MPC-6827 for Recurrent Glioblastoma Multiforme

Myrexis

NCT00892931

COMPLETED Phase 2 42 participants

Temozolomide Chronotherapy for High Grade Glioma

Washington University School of Medicine

NCT02781792

COMPLETED Phase 2 41 participants

Avastin/Temozolomide/Irinotecan for Unresectable/Multifocal Glioblastoma Multiforme

Katy Peters

NCT00979017

COMPLETED Phase 2 41 participants

Dose Confirmation Study of Cotara for the Treatment of Glioblastoma Multiforme at First Relapse

Peregrine Pharmaceuticals

NCT00677716

COMPLETED Phase 1 40 participants

A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma

Alaunos Therapeutics

NCT02026271

COMPLETED Phase 1 37 participants

A Dose Per Fraction Escalation Trial of Hypofractionated IMRT With Temozolomide for Newly Diagnosed Glioblastoma

University of Colorado, Denver

NCT00792012

COMPLETED Phase 1 36 participants

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

Julie Krystal

NCT01837862

COMPLETED Phase 2 36 participants

AMG 102 and Avastin for Recurrent Malignant Glioma

Katy Peters

NCT01113398

COMPLETED Phase 1 35 participants

Disulfiram/Copper With Concurrent Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma

Washington University School of Medicine

NCT02715609

COMPLETED Phase 1 32 participants

AMG 595 First-in-Human in Recurrent Gliomas

Amgen

NCT01475006

COMPLETED Phase 2 22 participants

A Phase 2 Evaluation of TRC105 In Combination With Bevacizumab in Patients With Glioblastoma

Tracon Pharmaceuticals

NCT01564914

COMPLETED Phase 1 22 participants

AZD8055 for Adults With Recurrent Gliomas

National Cancer Institute (NCI)

NCT01316809

COMPLETED Phase 1 12 participants

Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas

Biogen

NCT00031083

COMPLETED Phase 1 11 participants

Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma

Northwell Health

NCT00301418

COMPLETED Phase 1 10 participants

Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors

Monteris Medical

NCT00747253

COMPLETED Phase 1 10 participants

Cellular Immunotherapy Study for Brain Cancer

Jonsson Comprehensive Cancer Center

NCT01144247

COMPLETED Phase 1 9 participants

Cancer Stem Cell High-Throughput Drug Screening Study

Swedish Medical Center

NCT02654964

COMPLETED Phase 2 9 participants

GW572016 to Treat Recurrent Malignant Brain Tumors

National Cancer Institute (NCI)

NCT00107003

COMPLETED Phase 2 7 participants

Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma

National Cancer Institute (NCI)

NCT03027388

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Phase Distribution

PhaseTrial count
Phase 1 48
Phase 2 26
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glioblastoma Multiforme Trial Landscape

89 indexed Glioblastoma Multiforme studies · 37 recruiting (42%).

Phase mix: 1 late (III/IV) vs 74 early (I/II).

Top sponsor: Northwell Health (6 trials), 9 others listed. 39 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glioblastoma Multiforme?

PlainTrial tracks 89 US clinical trials for Glioblastoma Multiforme, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glioblastoma Multiforme?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.