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NCT07245303 · ClinicalTrials.gov registry record · NA
Neural Mechanisms of Light Driven Analgesia
A NA study of Fibromyalgia and Musculoskeletal Pain, sponsored by University of North Carolina, Chapel Hill.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT07245303: Recruiting NA study of Fibromyalgia and Musculoskeletal Pain, sponsored by University of North Carolina, Chapel Hill.
NCT07245303 is a NA study of Fibromyalgia and Musculoskeletal Pain that is actively recruiting participants, run by University of North Carolina, Chapel Hill. The registered enrollment target is 60 participants, below the 178-participant average among 76 other Fibromyalgia trials with a reported enrollment target (66% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07245303, a NA study of Fibromyalgia and Musculoskeletal Pain, is actively recruiting participants, sponsored by University of North Carolina, Chapel Hill.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical studies. In this study the investigators will evaluate the functional connectivity between subcortical visual areas and non-image forming brain areas that are involved in pain sensation. The investigators will also evaluate how three colored light stimuli presented to the retina results in changes in whole brain evoked activation patterns in participants with chronic musculoskeletal pain and in healthy controls. The investigators will also assess while brain evoked activation patterns in response to a pressure pain stimulus in the presence of three light stimuli in individuals with chronic musculoskeletal pain and healthy controls.
Primary Outcome
Functional connectivity assessed under three lighting conditions will be assessed with a seed voxel analysis with the seed region of interest set as the pregeniculate nucleus. A map of connectivity will be generated and displayed over inflated brain space. This map will be constructed by calculating the Fisher-transformed correlation coefficients between each voxel with the BOLD times series for the Pregeniculate nucleus. The higher the correlation coefficient, the stronger connectivity of each
Conditions Studied
Interventions
- OTHER S-cone modulating visual stimulus
- OTHER Equal Energy White Visual Stimulus
- OTHER Green light visual stimulus (S-OFF)
- OTHER Evoked Pressure Pain Stimulus
Study Locations (1)
North Carolina
- University of North Carolina at Chapel Hill - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-02-01 |
| Est. Completion | 2030-01-31 |
| Phase | NA |
What NCT07245303 shows while recruiting
NCT07245303 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 178-participant average among 76 other Fibromyalgia trials with a reported enrollment target (66% lower).
The record links to 3 conditions, with Fibromyalgia appearing as the primary indexed condition, and to 4 interventions - of which S-cone modulating visual stimulus is the first listed.
NCT07245303 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT07245303 about?
NCT07245303 is a clinical study titled "Neural Mechanisms of Light Driven Analgesia". The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical studies. In this study the investigators will evaluate the functional con...
What is the current status of trial NCT07245303?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2026-02-01. Estimated completion is 2030-01-31.
What conditions does trial NCT07245303 study?
This clinical trial studies the following conditions: Fibromyalgia, Musculoskeletal Pain, Healthy Controls Group - Age and Sex-matched.
What interventions are being tested in trial NCT07245303?
The interventions under investigation include: S-cone modulating visual stimulus (OTHER), Equal Energy White Visual Stimulus (OTHER), Green light visual stimulus (S-OFF) (OTHER), Evoked Pressure Pain Stimulus (OTHER).
Who is sponsoring clinical trial NCT07245303?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07245303 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Fibromyalgia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07245303's enrollment target sits among peer trials
60 41st of 76 higher than 32 of 76 other Fibromyalgia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Fibromyalgia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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