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RECRUITING NA

Neural Mechanisms of Light Driven Analgesia

NCT07245303 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical studies. In this study the investigators will evaluate the functional connectivity between subcortical visual areas and non-image forming brain areas that are involved in pain sensation. The investigators will also evaluate how three colored light stimuli presented to the retina results in changes in whole brain evoked activation patterns in participants with chronic musculoskeletal pain and in healthy controls. The investigators will also assess while brain evoked activation patterns in response to a pressure pain stimulus in the presence of three light stimuli in individuals with chronic musculoskeletal pain and healthy controls.

Interventions

  • OTHER S-cone modulating visual stimulus
  • OTHER Equal Energy White Visual Stimulus
  • OTHER Green light visual stimulus (S-OFF)
  • OTHER Evoked Pressure Pain Stimulus

Study Locations (1)

North Carolina

  • University of North Carolina at Chapel Hill — Chapel Hill

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2026-02-01
Est. Completion 2030-01-31
Phase NA

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07245303

The ClinicalTrials.gov registry entry for NCT07245303 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of North Carolina, Chapel Hill, which has 725 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Fibromyalgia appearing as the primary indexed condition, and to 4 interventions — of which S-cone modulating visual stimulus is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07245303 reports 1 study location spanning 1 distinct geographic area — top geographies include North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07245303 about?

NCT07245303 is a clinical study titled "Neural Mechanisms of Light Driven Analgesia". The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical studies. In this study the investigators will evaluate the functional con...

What is the current status of trial NCT07245303?

This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2026-02-01. Estimated completion is 2030-01-31.

What conditions does trial NCT07245303 study?

This clinical trial studies the following conditions: Fibromyalgia, Musculoskeletal Pain, Healthy Controls Group - Age and Sex-matched. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07245303?

The interventions under investigation include: S-cone modulating visual stimulus (OTHER), Equal Energy White Visual Stimulus (OTHER), Green light visual stimulus (S-OFF) (OTHER), Evoked Pressure Pain Stimulus (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07245303?

This trial is sponsored by University of North Carolina, Chapel Hill, which has 725 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07245303 being conducted?

This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial