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NCT06574165 · ClinicalTrials.gov registry record · NA
Relationships of Affect and Neuroinflammation With Clinical Pain in Veterans With Fibromyalgia
A NA study of Fibromyalgia, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06574165: Recruiting NA study of Fibromyalgia, sponsored by VA Office of Research and Development.
NCT06574165 is a NA study of Fibromyalgia that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 60 participants, below the 178-participant average among 76 other Fibromyalgia trials with a reported enrollment target (66% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06574165, a NA study of Fibromyalgia, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
Fibromyalgia (FM) is a chronic pain condition that disproportionately impacts Veterans. Individuals diagnosed with FM patients experience lower self-esteem and positive affect, as well as greater levels of depression, anxiety, negative affect, and pain catastrophizing. Among those experiencing FM, clinical and experimental pain are associated with specific dispositional trait profiles, which are indexed by levels of negative affect and positive affect. Neuroinflammation and inflammation also play a role in FM- related affect and pain. Recent studies that have highlighted neuroinflammation and inflammation as physiological mechanisms associated with changes in dysregulated affect and chronic pain. Veterans with FM can ameliorate dispositional traits-i.e., increasing positive affect and reducing negative affect-by participating in exercise. However, a gap exists regarding how to optimally engage Veterans with FM in an exercise program. Thus, to fully take advantage of all potential therapeutic benefits of exercise for FM, there is a critical need to identify those factors underlying exercise engagement for FM pain management. The purpose for this study is to 1) determine associations of dispositional trait styles, neuroinflammation, and inflammation with pain outcomes in Veterans with FM; and 2) develop and design a Veteran-informed exercise program.
Primary Outcome
As a measurement of affect, participants will complete the Positive and Negative Affect Schedule and indicate the frequency with which the participants generally experience 10 positive (i.e., interested, excited) and 10 negative (i.e., distressed, upset) feelings. Items are rated ranging from 1 (very slightly or not at all) to 5 (extremely) with a total subscale ranging from 10 to 50.
Conditions Studied
Interventions
- BEHAVIORAL Moderate Intensity Continuous Training
Study Locations (1)
Alabama
- Birmingham VA Medical Center, Birmingham, AL - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-11-01 |
| Est. Completion | 2026-10-30 |
| Phase | NA |
What NCT06574165 shows while recruiting
NCT06574165 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 178-participant average among 76 other Fibromyalgia trials with a reported enrollment target (66% lower).
The record links to 1 condition, with Fibromyalgia appearing as the primary indexed condition, and to 1 intervention - of which Moderate Intensity Continuous Training is the first listed.
NCT06574165 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT06574165 about?
NCT06574165 is a clinical study titled "Relationships of Affect and Neuroinflammation With Clinical Pain in Veterans With Fibromyalgia". Fibromyalgia (FM) is a chronic pain condition that disproportionately impacts Veterans. Individuals diagnosed with FM patients experience lower self-esteem and positive affect, as well as greater levels of depression, anxiety, negative affect, and pain catastrophizing. Among those experiencing FM, c...
What is the current status of trial NCT06574165?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2024-11-01. Estimated completion is 2026-10-30.
What conditions does trial NCT06574165 study?
This clinical trial studies the following conditions: Fibromyalgia.
What interventions are being tested in trial NCT06574165?
The interventions under investigation include: Moderate Intensity Continuous Training (BEHAVIORAL).
Who is sponsoring clinical trial NCT06574165?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06574165 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Fibromyalgia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06574165's enrollment target sits among peer trials
60 41st of 76 higher than 32 of 76 other Fibromyalgia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Fibromyalgia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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