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Epilepsy: early-phase trial registry
78 of 164 indexed Epilepsy trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #65 of 28,707 conditions by registered trial count.
164 US clinical trials · 78 currently recruiting · #65 of 28,707 conditions by registered trial count
Epilepsy: 164 US clinical trials tracked, 78 recruiting.
Epilepsy is the subject of 164 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 39 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Neurological Disorders and Stroke (NINDS), running 9 of these trials.
Enrollment posture brief
Registry condition epilepsy
OPEN 78 | RECR 48% | LATE 21 | EARLY 39 | RANK #65 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Microbial Colonization (48% recruiting · 21 trials)
Epilepsy lists 78 open slots (48% of 164 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Epilepsy on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Epilepsy is recruiting above its size-band peers.
78 of 164 indexed trials (47.6%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Epilepsy trials is spread across many organizations.
National Institute of Neurological Disorders and Stroke (NINDS) accounts for 9 of 164 trials (5.5%). 95 distinct sponsors appear on at least one study for this condition label.
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Most Epilepsy trials plan to enrol fewer than 100 people.
Median target enrolment is 60 among the 161 trials that report a genuine target (sentinel values excluded). 103 of those (64%) plan for fewer than 100 participants.
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Epilepsy research is mostly interventional.
120 interventional and 44 observational studies make up this index (73.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
164 total, page 3 of 4
Women With Epilepsy: Pregnancy Outcomes and Deliveries
NYU Langone Health
NCT01259310
Pediatric Epilepsy Study in Subjects 1-24 Months
GlaxoSmithKline
NCT00044278
Long Term Follow-up Study With Keppra XR (Levetiracetam XR) for Partial Seizures
UCB Pharma
NCT00419393
Search for Genes Influencing Childhood Absence Epilepsy (CAE) Study
Icahn School of Medicine at Mount Sinai
NCT00041951
A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults
Jazz Pharmaceuticals
NCT02224690
Study of an External Responsive Neurostimulator System on Epileptiform Activity
NeuroPace
NCT00158067
Pediatric Epilepsy Study
Novartis Pharmaceuticals
NCT00050934
Preventing Depression in People With Epilepsy: an Extension of Project UPLIFT
Emory University
NCT01941706
Hormone Replacement in Menopausal Women With Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00027209
High-density EEG in Neurological Disorders
Dartmouth-Hitchcock Medical Center
NCT04266041
Self-management for People With Epilepsy and a History of Negative Health Events
Case Western Reserve University
NCT02970396
Youth Epilepsy and Successful Self-Management Intervention
University of Minnesota
NCT03639233
Behavioral Economics and Adherence in Teens (BEAT!)
Children's Hospital Medical Center, Cincinnati
NCT03958331
Bipolar Disorder in Epilepsy
Northwell Health
NCT00365482
Open-label, Pharmacokinetic, Safety and Efficacy Study of Adjunctive Brivaracetam in Children With Epilepsy.
UCB Pharma
NCT00422422
A Complex Contraception Registry
University of California, San Diego
NCT02219269
Pediatric Epilepsy Study
Novartis Pharmaceuticals
NCT00050947
COPE Intervention for Parents of Children With Epilepsy
Boston Children's Hospital
NCT00767026
Adapting Project UPLIFT for Blacks in Georgia
Morehouse School of Medicine
NCT02909387
Study of Antiepileptic Drug Effects on Child Development
Augusta University
NCT00353886
Utilizing Activity Trackers to Promote Physical Activity in People With Epilepsy: Can we Make a Difference?
The University of Texas Health Science Center, Houston
NCT04357912
Trial to Evaluate the Effect of Eslicarbazepine Acetate on Cardiac Repolarization
Bial - Portela C S.A.
NCT02283788
A Computerized CBTi for Insomnia in Epilepsy
The Cleveland Clinic
NCT03632889
Flexible Representation of Speech
University of Pittsburgh
NCT05209386
Study of Intranasal Clonazepam in Adult Subjects With Epileptic Seizures
Jazz Pharmaceuticals
NCT00594945
Counseling on the Interaction of Hormonal Contraceptives and Antiepileptics
University of California, San Diego
NCT02485756
Evaluation of StatNet Device for Electroencephalogram (EEG) Recordings
Beth Israel Deaconess Medical Center
NCT03103425
IV Lacosamide: The Safety of Intravenous Lacosamide
Le Bonheur Children's Hospital
NCT01981447
TAK-935 Multiple Rising Dose Study in Healthy Participants
Takeda
NCT02539134
Open-Label Extension Study to Assess the Safety and Seizure Frequency Associated With Lacosamide for Primary Generalized Tonic-Clonic Seizures in Subjects With Epilepsy
UCB Biosciences
NCT01118962
Does Valproate Increase Levels of Folate Receptor Autoantibodies in Women?
Northwell Health
NCT01231646
Study of [11C]DPA-713 for Temporal Lobe Epilepsy
National Institute of Mental Health (NIMH)
NCT01793532
Non-Invasive Seizure Localization in Patients With Medically Refractory Localization Related Epilepsy: Synchronized MEG-EEG Recordings
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00071305
Cognitive Effects of Treatment of Interictal Discharges
Massachusetts General Hospital
NCT00916149
Diazepam Buccal Film (DBF) - Diastat Rectal Gel (DRG) Crossover Study
Aquestive Therapeutics
NCT03953820
Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI
Rup Kamal Sainju
NCT02929667
Use of the Atkins Diet for Adults With Intractable Epilepsy
Johns Hopkins University
NCT00121927
Open-Label PoC Trial of Ganaxolone in Children With PCDH19 Female Pediatric Epilepsy and Other Rare Genetic Epilepsies
Marinus Pharmaceuticals
NCT02358538
An Open-label, Single-centre Study Evaluating the Pharmacokinetics of Digoxin Alone and When Administered at Various Doses of Ezogabine/Retigabine in Healthy Adults. The Pharmacokinetics of Ezogabine/Retigabine and the N-acetyl Metabolite of Ezogabine/Retigabine (NAMR) Will Also be Assessed
GlaxoSmithKline
NCT01583036
Direct Cortical Measurement of the Intensity and Pattern of Current Flow Produced by TDCS
NYU Langone Health
NCT02263274
Does Memantine Improve Verbal Memory Task Performance in Subjects With Partial Epilepsy and Memory Dysfunction?
American Academy of Neurology
NCT01054599
A Study of Diazepam After Intranasal and Intravenous Administration to Healthy Volunteers
University of Minnesota
NCT01364558
Double Blind, Crossover Study of Fish Oil [EPA and DHA] for Intractable Partial Seizures
National Center for Complementary and Integrative Health (NCCIH)
NCT00871377
Levetiracetam: The Anti-Convulsant of Choice for Elderly Patients With Dementia
Drexel University College of Medicine
NCT01318408
Pharmacokinetics and Safety Study of Diazepam Buccal Film (DBF) in Pediatric Subjects With Epilepsy
Aquestive Therapeutics
NCT03222349
Epidiolex® for Anxiety in Pediatric Epilepsy
Hugo W. Moser Research Institute at Kennedy Krieger
NCT05324449
VNS Therapy Automatic Magnet Mode Outcomes Study in Epilepsy Patients Exhibiting Ictal Tachycardia (E-37)
Cyberonics
NCT01846741
Language and Emotional Function in Patients With Temporal Lobe Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00081432
Fycompa Titration Intervals and Effects on Retention Rate
University of Arizona
NCT03457129
Epilepsy Motion Sensing
MedtronicNeuro
NCT01850498
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 23 |
| Phase 2 | 16 |
| Phase 3 | 14 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Epilepsy records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Epilepsy trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Epilepsy page
164 registered trials, 78 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 78 Epilepsy trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Neurological Disorders and Stroke (NINDS) sponsors the most Epilepsy trials on record, review their full trial history before evaluating a specific study. See National Institute of Neurological Disorders and Stroke (NINDS)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Epilepsy condition card totals 164 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.