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ClinicalTrials.gov 78 recruiting now official registry

Epilepsy clinical trials

78 of 164 indexed Epilepsy trials are currently recruiting.

164 US clinical trials · 78 currently recruiting

Epilepsy is the subject of 164 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 39 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Neurological Disorders and Stroke (NINDS), running 9 of these trials.

The research picture

Epilepsy has 164 registered US clinical trials, 78 of them open to new participants right now, about 48% of the total.

78
recruiting participants now
48%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
9
top sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Phase 123Phase 216Phase 314Phase 47

Active & Recent Trials

164 total, page 3 of 4

COMPLETED 199 participants

Women With Epilepsy: Pregnancy Outcomes and Deliveries

NYU Langone Health

NCT01259310

COMPLETED Phase 2 197 participants

Pediatric Epilepsy Study in Subjects 1-24 Months

GlaxoSmithKline

NCT00044278

COMPLETED Phase 3 190 participants

Long Term Follow-up Study With Keppra XR (Levetiracetam XR) for Partial Seizures

UCB Pharma

NCT00419393

COMPLETED 185 participants

Search for Genes Influencing Childhood Absence Epilepsy (CAE) Study

Icahn School of Medicine at Mount Sinai

NCT00041951

COMPLETED Phase 3 171 participants

A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults

Jazz Pharmaceuticals

NCT02224690

COMPLETED Phase 2 150 participants

Study of an External Responsive Neurostimulator System on Epileptiform Activity

NeuroPace

NCT00158067

COMPLETED Phase 3 132 participants

Pediatric Epilepsy Study

Novartis Pharmaceuticals

NCT00050934

COMPLETED NA 130 participants

Preventing Depression in People With Epilepsy: an Extension of Project UPLIFT

Emory University

NCT01941706

COMPLETED Phase 2 125 participants

Hormone Replacement in Menopausal Women With Epilepsy

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00027209

COMPLETED NA 122 participants

High-density EEG in Neurological Disorders

Dartmouth-Hitchcock Medical Center

NCT04266041

COMPLETED NA 121 participants

Self-management for People With Epilepsy and a History of Negative Health Events

Case Western Reserve University

NCT02970396

COMPLETED NA 120 participants

Youth Epilepsy and Successful Self-Management Intervention

University of Minnesota

NCT03639233

COMPLETED NA 104 participants

Behavioral Economics and Adherence in Teens (BEAT!)

Children's Hospital Medical Center, Cincinnati

NCT03958331

COMPLETED 102 participants

Bipolar Disorder in Epilepsy

Northwell Health

NCT00365482

COMPLETED Phase 2 100 participants

Open-label, Pharmacokinetic, Safety and Efficacy Study of Adjunctive Brivaracetam in Children With Epilepsy.

UCB Pharma

NCT00422422

COMPLETED 97 participants

A Complex Contraception Registry

University of California, San Diego

NCT02219269

COMPLETED Phase 3 94 participants

Pediatric Epilepsy Study

Novartis Pharmaceuticals

NCT00050947

COMPLETED Phase 1 88 participants

COPE Intervention for Parents of Children With Epilepsy

Boston Children's Hospital

NCT00767026

COMPLETED NA 82 participants

Adapting Project UPLIFT for Blacks in Georgia

Morehouse School of Medicine

NCT02909387

COMPLETED 81 participants

Study of Antiepileptic Drug Effects on Child Development

Augusta University

NCT00353886

COMPLETED NA 80 participants

Utilizing Activity Trackers to Promote Physical Activity in People With Epilepsy: Can we Make a Difference?

The University of Texas Health Science Center, Houston

NCT04357912

COMPLETED Phase 1 67 participants

Trial to Evaluate the Effect of Eslicarbazepine Acetate on Cardiac Repolarization

Bial - Portela C S.A.

NCT02283788

COMPLETED NA 50 participants

A Computerized CBTi for Insomnia in Epilepsy

The Cleveland Clinic

NCT03632889

COMPLETED NA 48 participants

Flexible Representation of Speech

University of Pittsburgh

NCT05209386

COMPLETED Phase 2 45 participants

Study of Intranasal Clonazepam in Adult Subjects With Epileptic Seizures

Jazz Pharmaceuticals

NCT00594945

COMPLETED NA 42 participants

Counseling on the Interaction of Hormonal Contraceptives and Antiepileptics

University of California, San Diego

NCT02485756

COMPLETED 40 participants

Evaluation of StatNet Device for Electroencephalogram (EEG) Recordings

Beth Israel Deaconess Medical Center

NCT03103425

COMPLETED Phase 3 40 participants

IV Lacosamide: The Safety of Intravenous Lacosamide

Le Bonheur Children's Hospital

NCT01981447

COMPLETED Phase 1 40 participants

TAK-935 Multiple Rising Dose Study in Healthy Participants

Takeda

NCT02539134

COMPLETED Phase 2 39 participants

Open-Label Extension Study to Assess the Safety and Seizure Frequency Associated With Lacosamide for Primary Generalized Tonic-Clonic Seizures in Subjects With Epilepsy

UCB Biosciences

NCT01118962

COMPLETED 38 participants

Does Valproate Increase Levels of Folate Receptor Autoantibodies in Women?

Northwell Health

NCT01231646

COMPLETED 38 participants

Study of [11C]DPA-713 for Temporal Lobe Epilepsy

National Institute of Mental Health (NIMH)

NCT01793532

COMPLETED 35 participants

Non-Invasive Seizure Localization in Patients With Medically Refractory Localization Related Epilepsy: Synchronized MEG-EEG Recordings

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00071305

COMPLETED NA 31 participants

Cognitive Effects of Treatment of Interictal Discharges

Massachusetts General Hospital

NCT00916149

COMPLETED Phase 1 31 participants

Diazepam Buccal Film (DBF) - Diastat Rectal Gel (DRG) Crossover Study

Aquestive Therapeutics

NCT03953820

COMPLETED Phase 2 30 participants

Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI

Rup Kamal Sainju

NCT02929667

COMPLETED NA 30 participants

Use of the Atkins Diet for Adults With Intractable Epilepsy

Johns Hopkins University

NCT00121927

COMPLETED Phase 2 30 participants

Open-Label PoC Trial of Ganaxolone in Children With PCDH19 Female Pediatric Epilepsy and Other Rare Genetic Epilepsies

Marinus Pharmaceuticals

NCT02358538

COMPLETED Phase 1 30 participants

An Open-label, Single-centre Study Evaluating the Pharmacokinetics of Digoxin Alone and When Administered at Various Doses of Ezogabine/Retigabine in Healthy Adults. The Pharmacokinetics of Ezogabine/Retigabine and the N-acetyl Metabolite of Ezogabine/Retigabine (NAMR) Will Also be Assessed

GlaxoSmithKline

NCT01583036

COMPLETED NA 30 participants

Direct Cortical Measurement of the Intensity and Pattern of Current Flow Produced by TDCS

NYU Langone Health

NCT02263274

COMPLETED NA 29 participants

Does Memantine Improve Verbal Memory Task Performance in Subjects With Partial Epilepsy and Memory Dysfunction?

American Academy of Neurology

NCT01054599

COMPLETED Phase 1 24 participants

A Study of Diazepam After Intranasal and Intravenous Administration to Healthy Volunteers

University of Minnesota

NCT01364558

COMPLETED Phase 2 24 participants

Double Blind, Crossover Study of Fish Oil [EPA and DHA] for Intractable Partial Seizures

National Center for Complementary and Integrative Health (NCCIH)

NCT00871377

COMPLETED Phase 4 24 participants

Levetiracetam: The Anti-Convulsant of Choice for Elderly Patients With Dementia

Drexel University College of Medicine

NCT01318408

COMPLETED Phase 2 24 participants

Pharmacokinetics and Safety Study of Diazepam Buccal Film (DBF) in Pediatric Subjects With Epilepsy

Aquestive Therapeutics

NCT03222349

COMPLETED Phase 4 20 participants

Epidiolex® for Anxiety in Pediatric Epilepsy

Hugo W. Moser Research Institute at Kennedy Krieger

NCT05324449

COMPLETED NA 20 participants

VNS Therapy Automatic Magnet Mode Outcomes Study in Epilepsy Patients Exhibiting Ictal Tachycardia (E-37)

Cyberonics

NCT01846741

COMPLETED 20 participants

Language and Emotional Function in Patients With Temporal Lobe Epilepsy

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00081432

COMPLETED Phase 4 20 participants

Fycompa Titration Intervals and Effects on Retention Rate

University of Arizona

NCT03457129

COMPLETED 19 participants

Epilepsy Motion Sensing

MedtronicNeuro

NCT01850498

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Phase Distribution

PhaseTrial count
Phase 1 23
Phase 2 16
Phase 3 14
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Epilepsy Trial Landscape

164 indexed Epilepsy studies · 78 recruiting (48%).

Phase mix: 21 late (III/IV) vs 39 early (I/II).

Top sponsor: National Institute of Neurological Disorders and Stroke (NINDS) (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Epilepsy?

PlainTrial tracks 164 US clinical trials for Epilepsy, of which 78 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Epilepsy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.