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Epilepsy clinical trials
78 of 164 indexed Epilepsy trials are currently recruiting.
164 US clinical trials · 78 currently recruiting
Epilepsy is the subject of 164 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 39 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Neurological Disorders and Stroke (NINDS), running 9 of these trials.
The research picture
Epilepsy has 164 registered US clinical trials, 78 of them open to new participants right now, about 48% of the total.
- 78
- recruiting participants now
- 48%
- of trials open to enrollment
- 21
- in Phase 3–4 (later-stage)
- 9
- top sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Active & Recent Trials
164 total, page 3 of 4
Women With Epilepsy: Pregnancy Outcomes and Deliveries
NYU Langone Health
NCT01259310
Pediatric Epilepsy Study in Subjects 1-24 Months
GlaxoSmithKline
NCT00044278
Long Term Follow-up Study With Keppra XR (Levetiracetam XR) for Partial Seizures
UCB Pharma
NCT00419393
Search for Genes Influencing Childhood Absence Epilepsy (CAE) Study
Icahn School of Medicine at Mount Sinai
NCT00041951
A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults
Jazz Pharmaceuticals
NCT02224690
Study of an External Responsive Neurostimulator System on Epileptiform Activity
NeuroPace
NCT00158067
Pediatric Epilepsy Study
Novartis Pharmaceuticals
NCT00050934
Preventing Depression in People With Epilepsy: an Extension of Project UPLIFT
Emory University
NCT01941706
Hormone Replacement in Menopausal Women With Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00027209
High-density EEG in Neurological Disorders
Dartmouth-Hitchcock Medical Center
NCT04266041
Self-management for People With Epilepsy and a History of Negative Health Events
Case Western Reserve University
NCT02970396
Youth Epilepsy and Successful Self-Management Intervention
University of Minnesota
NCT03639233
Behavioral Economics and Adherence in Teens (BEAT!)
Children's Hospital Medical Center, Cincinnati
NCT03958331
Bipolar Disorder in Epilepsy
Northwell Health
NCT00365482
Open-label, Pharmacokinetic, Safety and Efficacy Study of Adjunctive Brivaracetam in Children With Epilepsy.
UCB Pharma
NCT00422422
A Complex Contraception Registry
University of California, San Diego
NCT02219269
Pediatric Epilepsy Study
Novartis Pharmaceuticals
NCT00050947
COPE Intervention for Parents of Children With Epilepsy
Boston Children's Hospital
NCT00767026
Adapting Project UPLIFT for Blacks in Georgia
Morehouse School of Medicine
NCT02909387
Study of Antiepileptic Drug Effects on Child Development
Augusta University
NCT00353886
Utilizing Activity Trackers to Promote Physical Activity in People With Epilepsy: Can we Make a Difference?
The University of Texas Health Science Center, Houston
NCT04357912
Trial to Evaluate the Effect of Eslicarbazepine Acetate on Cardiac Repolarization
Bial - Portela C S.A.
NCT02283788
A Computerized CBTi for Insomnia in Epilepsy
The Cleveland Clinic
NCT03632889
Flexible Representation of Speech
University of Pittsburgh
NCT05209386
Study of Intranasal Clonazepam in Adult Subjects With Epileptic Seizures
Jazz Pharmaceuticals
NCT00594945
Counseling on the Interaction of Hormonal Contraceptives and Antiepileptics
University of California, San Diego
NCT02485756
Evaluation of StatNet Device for Electroencephalogram (EEG) Recordings
Beth Israel Deaconess Medical Center
NCT03103425
IV Lacosamide: The Safety of Intravenous Lacosamide
Le Bonheur Children's Hospital
NCT01981447
TAK-935 Multiple Rising Dose Study in Healthy Participants
Takeda
NCT02539134
Open-Label Extension Study to Assess the Safety and Seizure Frequency Associated With Lacosamide for Primary Generalized Tonic-Clonic Seizures in Subjects With Epilepsy
UCB Biosciences
NCT01118962
Does Valproate Increase Levels of Folate Receptor Autoantibodies in Women?
Northwell Health
NCT01231646
Study of [11C]DPA-713 for Temporal Lobe Epilepsy
National Institute of Mental Health (NIMH)
NCT01793532
Non-Invasive Seizure Localization in Patients With Medically Refractory Localization Related Epilepsy: Synchronized MEG-EEG Recordings
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00071305
Cognitive Effects of Treatment of Interictal Discharges
Massachusetts General Hospital
NCT00916149
Diazepam Buccal Film (DBF) - Diastat Rectal Gel (DRG) Crossover Study
Aquestive Therapeutics
NCT03953820
Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI
Rup Kamal Sainju
NCT02929667
Use of the Atkins Diet for Adults With Intractable Epilepsy
Johns Hopkins University
NCT00121927
Open-Label PoC Trial of Ganaxolone in Children With PCDH19 Female Pediatric Epilepsy and Other Rare Genetic Epilepsies
Marinus Pharmaceuticals
NCT02358538
An Open-label, Single-centre Study Evaluating the Pharmacokinetics of Digoxin Alone and When Administered at Various Doses of Ezogabine/Retigabine in Healthy Adults. The Pharmacokinetics of Ezogabine/Retigabine and the N-acetyl Metabolite of Ezogabine/Retigabine (NAMR) Will Also be Assessed
GlaxoSmithKline
NCT01583036
Direct Cortical Measurement of the Intensity and Pattern of Current Flow Produced by TDCS
NYU Langone Health
NCT02263274
Does Memantine Improve Verbal Memory Task Performance in Subjects With Partial Epilepsy and Memory Dysfunction?
American Academy of Neurology
NCT01054599
A Study of Diazepam After Intranasal and Intravenous Administration to Healthy Volunteers
University of Minnesota
NCT01364558
Double Blind, Crossover Study of Fish Oil [EPA and DHA] for Intractable Partial Seizures
National Center for Complementary and Integrative Health (NCCIH)
NCT00871377
Levetiracetam: The Anti-Convulsant of Choice for Elderly Patients With Dementia
Drexel University College of Medicine
NCT01318408
Pharmacokinetics and Safety Study of Diazepam Buccal Film (DBF) in Pediatric Subjects With Epilepsy
Aquestive Therapeutics
NCT03222349
Epidiolex® for Anxiety in Pediatric Epilepsy
Hugo W. Moser Research Institute at Kennedy Krieger
NCT05324449
VNS Therapy Automatic Magnet Mode Outcomes Study in Epilepsy Patients Exhibiting Ictal Tachycardia (E-37)
Cyberonics
NCT01846741
Language and Emotional Function in Patients With Temporal Lobe Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00081432
Fycompa Titration Intervals and Effects on Retention Rate
University of Arizona
NCT03457129
Epilepsy Motion Sensing
MedtronicNeuro
NCT01850498
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 23 |
| Phase 2 | 16 |
| Phase 3 | 14 |
| Phase 4 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Epilepsy Trial Landscape
164 indexed Epilepsy studies · 78 recruiting (48%).
Phase mix: 21 late (III/IV) vs 39 early (I/II).
Top sponsor: National Institute of Neurological Disorders and Stroke (NINDS) (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Epilepsy?
PlainTrial tracks 164 US clinical trials for Epilepsy, of which 78 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Epilepsy?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.