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NCT05854160 · ClinicalTrials.gov registry record · NA

Stimulation-Induced Changes in Fronto-Limbic Network

A NA study of Epilepsy and Mental Disorders, sponsored by University of Alabama at Birmingham.

Recruiting
Registry status
NA
Development phase
30
Enrollment target
1
Study location

NCT05854160: Recruiting NA study of Epilepsy and Mental Disorders, sponsored by University of Alabama at Birmingham.

NCT05854160 is a NA study of Epilepsy and Mental Disorders that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 30 participants, below the 952-participant average among 160 other Epilepsy trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05854160, a NA study of Epilepsy and Mental Disorders, is actively recruiting participants, sponsored by University of Alabama at Birmingham.

RECRUITING
Registry status
NA
Development phase
30 participants
Enrollment target
1
Study location

Study Summary

The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to assess different aspects of emotion processing. Stimulation pulses during pre and post-test periods will assess the effects of stimulation before and after conditioning, the results of which will be combined with results from the activity of each electrode during the emotion tasks to inform us of the nature of emotion processing in the brain and allow us to devise brain modulation protocols in the future.

Primary Outcome

We will test for a positive linear relationship (Pearson r correlation test) between dmPFC to amygdala connectivity values (Granger causality coefficient; sEEG) and physiologic (Skin conductance beta estimates; finger electrodes) and cognitive (self-report; expectancy) threat regulation measures.

Conditions Studied

Epilepsy Mental Disorders

Interventions

  • PROCEDURE Electrical Pulse Train Stimulation

Study Locations (1)

Alabama

  • Epilepsy Monitoring Unit UAB Hospital - Birmingham

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2023-03-01
Est. Completion 2027-04-30
Phase NA
University of Alabama at Birmingham

1,160 total trials

What NCT05854160 shows while recruiting

NCT05854160 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 952-participant average among 160 other Epilepsy trials with a reported enrollment target (97% lower).

The record links to 2 conditions, with Epilepsy appearing as the primary indexed condition, and to 1 intervention - of which Electrical Pulse Train Stimulation is the first listed.

NCT05854160 reports a single indexed study location in Alabama.

Frequently Asked Questions

What is clinical trial NCT05854160 about?

NCT05854160 is a clinical study titled "Stimulation-Induced Changes in Fronto-Limbic Network". The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to ass...

What is the current status of trial NCT05854160?

This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2023-03-01. Estimated completion is 2027-04-30.

What conditions does trial NCT05854160 study?

This clinical trial studies the following conditions: Epilepsy, Mental Disorders.

What interventions are being tested in trial NCT05854160?

The interventions under investigation include: Electrical Pulse Train Stimulation (PROCEDURE).

Who is sponsoring clinical trial NCT05854160?

This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05854160 being conducted?

This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Epilepsy

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05854160's enrollment target sits among peer trials

30 109th of 160 higher than 41 of 160 other Epilepsy trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Epilepsy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05854160

Source: ClinicalTrials.gov NCT05854160, the US trial registry maintained by the National Library of Medicine. NCT05854160 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.