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2026 data Public-data reference. official source

Eosinophilic Esophagitis

Open-data reference.

45 US clinical trials · 14 currently recruiting

Active & Recent Trials

RECRUITING 23,000 participants

A Registry for the Food Allergy Community

Food Allergy Research & Education

NCT04653324

RECRUITING 5,000 participants

Indiana University Gastrointestinal Motility Diagnosis Registry

Indiana University

NCT04506593

RECRUITING 1,800 participants

Natural History and Genetics of Food Allergy and Related Conditions

National Institute of Allergy and Infectious Diseases (NIAID)

NCT02504853

RECRUITING 1,500 participants

Characteristics and Inflammatory Markers in Children with Eosinophilic Esophagitis (EoE)

University of California, San Diego

NCT03980886

RECRUITING 1,350 participants

OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages

Children's Hospital Medical Center, Cincinnati

NCT02523118

RECRUITING 500 participants

Eosinophilic Gastrointestinal Disorders Registry

Ann & Robert H Lurie Children's Hospital of Chicago

NCT05199532

RECRUITING Phase 3 308 participants

Once Daily Versus Twice Daily Budesonide Orodispersible Tablets for Induction of Remission in EoE

Dr. Falk Pharma

NCT06596252

RECRUITING Phase 2 80 participants

A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks

Phathom Pharmaceuticals

NCT06851559

RECRUITING Phase 2 72 participants

Dupilumab Versus Topical Corticosteroid Effectiveness - Comparison in the Treatment of Stenotic EoE

University of Colorado, Denver

NCT06705387

RECRUITING NA 70 participants

The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States

National Institute of Allergy and Infectious Diseases (NIAID)

NCT07027826

RECRUITING 50 participants

Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:

Medical College of Wisconsin

NCT07227506

RECRUITING NA 40 participants

Patient-Centered Decision Support for Eosinophilic Esophagitis

University of Michigan

NCT06817213

RECRUITING Phase 2 15 participants

Zemaira Eosinophilic Esophagitis Pilot Study

Children's Hospital Medical Center, Cincinnati

NCT05485155

RECRUITING 10 participants

Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study

Indiana University

NCT03312686

ACTIVE NOT RECRUITING 800 participants

Risk Factors and Biomarkers for Diagnosis and Treatment of EoE

University of North Carolina, Chapel Hill

NCT01988285

ACTIVE NOT RECRUITING 440 participants

Esophageal String Test in Eosinophilic Esophagitis

University of Colorado, Denver

NCT02008903

ACTIVE NOT RECRUITING Phase 3 368 participants

Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis

AstraZeneca

NCT05583227

ACTIVE NOT RECRUITING Phase 3 368 participants

Safety Study of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis

Celgene

NCT04991935

ACTIVE NOT RECRUITING 300 participants

Prospective Database for Eosinophilic Esophagitis (EoE) of Pediatric Population

Ann & Robert H Lurie Children's Hospital of Chicago

NCT05176249

ACTIVE NOT RECRUITING NA 100 participants

The Immune Directed Individualized Elimination Therapy (iDIET) Study

University of North Carolina, Chapel Hill

NCT05543512

ACTIVE NOT RECRUITING NA 96 participants

Using Spectrally Encoded Confocal Microscopy (SECM) to Image the Esophagus

Massachusetts General Hospital

NCT02202590

ACTIVE NOT RECRUITING Phase 4 90 participants

Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis Assessed by Transnasal Endoscopy (TNE)

University of Colorado, Denver

NCT04149470

ACTIVE NOT RECRUITING 88 participants

Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis

Ann & Robert H Lurie Children's Hospital of Chicago

NCT03822325

ACTIVE NOT RECRUITING 64 participants

A Prospective Study of the Four Food Elimination Diet for Treatment of Eosinophilic Esophagitis

Ann & Robert H Lurie Children's Hospital of Chicago

NCT05176262

ACTIVE NOT RECRUITING 54 participants

Morphological Markers of Gastroesophageal Reflux Disease (GERD)

Baylor College of Medicine

NCT01921686

ACTIVE NOT RECRUITING 54 participants

Cow's Milk Elimination for Treatment of Eosinophilic Esophagitis

Ann & Robert H Lurie Children's Hospital of Chicago

NCT05083156

ACTIVE NOT RECRUITING 50 participants

Efficacy of Low-Dose Topical Steroids in Maintaining Remission of Eosinophilic Esophagitis in Children

Ann & Robert H Lurie Children's Hospital of Chicago

NCT05309590

COMPLETED Phase 3 321 participants

Study to Determine the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Eosinophilic Esophagitis (EoE)

Regeneron Pharmaceuticals

NCT03633617

COMPLETED Phase 2 227 participants

Efficacy and Safety Study of Reslizumab to Treat Eosinophilic Esophagitis in Subjects Aged 5 to 18 Years

Ception Therapeutics

NCT00538434

COMPLETED NA 179 participants

Comparing Anesthetic Techniques in Children Having Esophagogastroduodenoscopies

Children's Hospital Medical Center, Cincinnati

NCT02038894

COMPLETED Phase 3 143 participants

Efficacy and Safety APT-1011 in Adult Subjects With Eosinophilic Esophagitis (EoE) (FLUTE-2)

Ellodi Pharmaceuticals

NCT04281108

COMPLETED Phase 2 108 participants

A Study to Assess the Safety and Efficacy of Oral Etrasimod in Adult Participants With Eosinophilic Esophagitis

Pfizer

NCT04682639

COMPLETED Phase 2 100 participants

Dose Ranging Study of RPC4046 in Eosinophilic Esophagitis

Celgene

NCT02098473

COMPLETED Phase 2 51 participants

The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis

Mayo Clinic

NCT00728481

COMPLETED Phase 2 42 participants

A Study of Flovent in Patients With Eosinophilic Esophagitis

Marc Rothenberg, MD

NCT00426283

COMPLETED Phase 2 25 participants

Efficacy and Safety of QAX576 in Patients With Eosinophilic Esophagitis

Novartis Pharmaceuticals

NCT01022970

COMPLETED Phase 1 24 participants

Safety and Tolerability Study of Oral EUR-1100 to Treat Eosinophilic Esophagitis

Forest Laboratories

NCT01386112

COMPLETED NA 22 participants

Cytosponge and Dietary Therapy in EoE

Mayo Clinic

NCT02599558

COMPLETED NA 22 participants

A Food Additive Removal Diet for Pediatric Eosinophilic Esophagitis

Nemours Children's Clinic

NCT03657771

COMPLETED Phase 4 21 participants

Efficacy of Dupilumab on Facilitated Food Introduction in Eosinophilic Esophagitis

Children's Hospital of Philadelphia

NCT05247866

COMPLETED NA 21 participants

Use of Esophageal String Test to Understand Symptoms, Inflammation, and Function in Eosinophilic Esophagitis

University of Colorado, Denver

NCT03305653

COMPLETED Phase 4 16 participants

Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis

University of Tennessee

NCT02371941

COMPLETED 16 participants

a4b7 Integrin in Eosinophilic Esophagitis

Massachusetts General Hospital

NCT02546219

COMPLETED Early Phase 1 8 participants

Radiation Dose in Humans From Orally Administered Tc99m-Heparin

University of Utah

NCT04069429

COMPLETED Phase 2 6 participants

Testing Effectiveness of Losartan in Patients With EoE With or Without a CTD

Children's Hospital Medical Center, Cincinnati

NCT01808196

Phase Distribution

PhaseTrial count
Early Phase 1 2
Phase 2 10
Phase 3 5
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Eosinophilic Esophagitis Trial Landscape

ClinicalTrials.gov lists 45 US studies indexed under Eosinophilic Esophagitis, and 14 of those are currently open to recruitment — roughly 31% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Eosinophilic Esophagitis shows 8 late-stage studies (Phase 3 and Phase 4 combined) alongside 12 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Eosinophilic Esophagitis is led by Ann & Robert H Lurie Children's Hospital of Chicago with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 45 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Eosinophilic Esophagitis?

PlainTrial tracks 45 US clinical trials for Eosinophilic Esophagitis, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Eosinophilic Esophagitis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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